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A2452 Sigma

N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-methylcoumarin

≥99% (TLC), powder

Synonym: Ac-YVAD-AMC

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Properties

Related Categories Apoptosis Enzymes, Apoptosis and Cell Cycle, Application Index, Biochemicals and Reagents, Caspase 1,
InChI Key   YGLOALWHJIANIH-UHFFFAOYSA-N
assay   ≥99% (TLC)
form   powder
composition   Peptide content, ≥80%
solubility   DMSO: soluble10 mM (The solution is stable in the dark at −20 °C for more than 1 month if no water is present.)
storage temp.   −20°C
Gene Information   human ... CASP1(834), CASP4(837)
mouse ... CASP1(12362), CASP4(12363)
rat ... CASP1(25166), CASP4(114555)

Description

Amino Acid Sequence

NAc-Tyr-Val-Ala-Asp-AMC

Caution

The lyophilized powder is stable below 0 °C for more than one year if kept dry and protected from light.

Substrates

Fluorogenic substrate for caspase 1 (Km = 14 μM) and caspase 4 (TX), cysteine proteases involved in apoptosis and inflammation.

Price and Availability


Flow Cytometry Instruments

Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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