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A2487 Sigma

Cotrimoxazole, Ready Made Solution

100 mg/mL in DMSO

Synonym: Trimethoprim-Sulfamethoxazole, TMP-SMX

  • CAS Number 8064-90-2

  • Empirical Formula (Hill Notation) C14H18N4O3 · 5 C10H11N3O3S

  • Molecular Weight 1556.71

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Properties

form   liquid
concentration   100 mg/mL in DMSO
color   colorless to faint yellow
Mode of action   DNA synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
  fungi
  parasites
shipped in   dry ice
storage temp.   −20°C

Description

Packaging

1ml

Preparation Note

prepared using a 1:5 mixture of trimethoprim:sulfamethoxazole

Application

Cotrimoxazole has been used as an antimicrobial agent.

Biochem/physiol Actions

Cotrimoxazole, a combination of trimethoprim and sulfamethoxazole, interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase (DHFR) which inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF), resulting in an antimicrobial effect. Sulfamethoxazole interferes with the synthesis of nucleic acids in sensitive microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net effect of these actions is to inhibit thymidine synthesis which prevents bacterial DNA synthesis.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
UV8240000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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