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A2731 Sigma

AMG 9810

≥98% (HPLC), powder

Synonym: 2E-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-Propenamide

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Properties

Related Categories A-AM, Amgen, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
InChI Key   GZTFUVZVLYUPRG-IZZDOVSWSA-N
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: >5 mg/mL
originator   Amgen
storage temp.   2-8°C

Description

Biochem/physiol Actions

AMG 9810 is a potent, non-vanilloid, antagonist of the TRPV1 receptor. IC50 = 17 nM.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by Amgen. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

Discover Bioactive Small Molecules for Ion Channels Research

Ion transport across the relatively impermeable lipid bilayer of the cell membrane is accomplished via membrane proteins known as ion channels, pumps and transporters. Ion channels are gated pores an...
Keywords: Biological processes, Cell signaling, Diseases, Hormones, Ligands, Neurotransmitters

Transient Receptor Potential Channels

The transient receptor potential family of ion channels consists of at least 28 mammalian members divided into six subfamilies: 7 TRPC (canonical), 6 TRPV (vanilloid), 8 TRPM (melastatin), 1 TRPA (an...
Keywords: Absorption, Apoptosis, Atomic absorption spectroscopy, Cancer, Diabetes, Endocannabinoids, Gene expression, Growth factors, Neurotransmitters, Pulsed discharge ionization detector, Respiratory, Transduction, Vitamins

Peer-Reviewed Papers
15

References

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