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A3411 Sigma

Aminopterin

powder, BioReagent, suitable for cell culture

Synonym: (S)-2-{4-[(2,4-Diaminopteridin-6-yl)methylamino]benzamido}pentanedioic acid, 4-Amino-PGA, 4-Aminofolic acid, 4-Aminopteroyl-L-glutamic acid

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Properties

Related Categories Cell Biology, Cell Culture, Conditioned Media, Media Supplements and Reagents, Folic Acid Metabolism, Hybridoma Reagents,
InChI Key   TVZGACDUOSZQKY-LBPRGKRZSA-N
product line   BioReagent
assay   ~98%
form   powder
color   yellow
solubility   2 M NaOH: soluble50 mg/mL
  DMSO: soluble
absorption   ε1M/261 nm, 0.1 M NaOH 25,700
  ε1M/282 nm, 0.1 M NaOH 24,500
  ε1M/373 nm, 0.1 M NaOH 8,100
suitability   suitable for cell culture
storage temp.   −20°C
Gene Information   human ... FPGS(2356)
mouse ... Fpgs(14287)

Description

Linkage

More potent, but more toxic, than methotrexate.

Biochem/physiol Actions

Folic acid antagonist. Aminopterin is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase that, in turn, binds to dihydrofolate reductase and inhibits its activity. Aminopterin-polyglutamate is degraded intracellularly by γ-glutamyl hydrolase.

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGI
WGK Germany 
3
RTECS 
MA1050000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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A5159 Aminopterin, Hybri-Max, 50 ×, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma
06693 Timestrip Plus -20 °C

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