Aminopterin
powder, BioReagent, suitable for cell culture
DOWNLOAD MSDS (PDF)Synonym:
4-Amino-PGA,
4-Aminofolic acid,
4-Aminopteroyl-
-
CAS Number 54-62-6
-
Empirical Formula (Hill Notation) C19H20N8O5
-
Molecular Weight 440.41
-
Beilstein Registry Number 69045
-
EC Number 200-209-9
-
MDL number MFCD00036692
-
PubChem Substance ID 24890768
-
Popular Documents: Specification Sheet (PDF) | FTNMR (PDF)
Properties
| Related Categories | A-AM, Bioactive Small Molecules, Cell Biology, Cell Culture, Conditioned Media, Media Supplements and Reagents, |
| product line | BioReagent |
| assay | ~98% |
| form | powder |
| color | yellow |
| solubility | 2 M NaOH: soluble50 mg/mL |
| DMSO: soluble | |
| abs. |
ε |
Description
Linkage
More potent, but more toxic, than methotrexate.
Biochem/physiol Actions
Folic acid antagonist. Aminopterin is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase that, in turn, binds to dihydrofolate reductase and inhibits its activity. Aminopterin-polyglutamate is degraded intracellularly by γ-glutamyl hydrolase.
Price and Availability
NEW! Sigma® Cultureware
Introducing Sigma’s new competitively priced line of cultureware:
- . Multiwell Plates
- . Culture Flasks
- . Cryogenic Vials & More
Customers Also Viewed
γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma
Technical Service:
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Bulk Ordering & Pricing:
Need larger quantities for your development, manufacturing or research applications?
