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A3672 Sigma

Azurin

from Pseudomonas aeruginosa, lyophilized powder

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Properties

Related Categories Biochemicals and Reagents, Proteins and Derivatives, Redox More...
biological source   from Pseudomonas aeruginosa
form   lyophilized powder
composition   Protein, ≥65% Lowry
storage temp.   −20°C

Description

Packaging

1 mg in glass bottle

Physical form

Lyophilized powder containing ammonium acetate buffer salts.

Biochem/physiol Actions

Azurin is a metalloprotein in the family of cupredoxins. It preferentially enters cancer cells over normal cells and induces apoptosis. Azurin has structural similarities to ephrinB2, and in fact binds the ephrin receptor tyrosine kinase EphB2 to initiate cell signaling that is involved in cancer progression. Azurin inhibits autophosphorlyation of the EphB2 tyrosine residue, interfering with upstream cell signaling and contributing to cancer cell growth inhibition.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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