Empirical Formula (Hill Notation) C19H28O8
Molecular Weight 384.42
|Related Categories||Anti-Proliferative Agents, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antiparasitic / Antiprotozoal / Anthelminthic,|
|biological source||from Artemisia annua|
|storage temp.||room temp|
Artesunate is a semisynthetic derivative of artemisinin used to treat malaria.3 It has also been shown to effective against other parasites such as liver flukes.4 Artesunate also demonstrates cytotoxic action against cancer cell lines of different tumor types.5
Using a yeast model, it has been demonstrated that Artesunate acts on the electron transport chain, generates local reactive oxygen species, and causes the depolarization of the mitochondrial membrane 1. Artesunate has been shown to inhibit TNF--induced production of proinflammatory cytokines via inhibition of NF-B and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes 2.
100, 500 mg in poly bottle
Certificate of Analysis
Certificate of Origin
Traditional Chinese Medicine (TCM) is a healing art that has been practiced for thousands of years. The practice of TCM is a holistic approach that includes the use of herbal preparations, acupunctur...
Lynn Stephenson, Product Specialist, Sigma® Life Science and Chloe McClanahan, Product Manager, Sigma Life Science
Biofiles Vol. 8, No. 6
Keywords: Analgesics, Antitumor agents, Apoptosis, Cancer, Drug discovery, Fractionation, High performance liquid chromatography, Metabolites, Metabolomics, Nuclear magnetic resonance spectroscopy, Pharmaceutical
2. Anti-malarial agent artesunate inhibits TNF--induced production of proinflammatory cytokines via inhibition of NF-B and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes. H. Xu, Y. He, X. Yang, et al. Rheumatology 46, 920-926, (2007)
4. Keiser, J., et. al. Antimicrob. Agents Chemother. 57, 1139-1145, (2006)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?