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A3731 Sigma

Artesunate

from Artemisia annua

  • Empirical Formula (Hill Notation) C19H28O8

  • Molecular Weight 384.42

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Description

Biochem/physiol Actions

Artesunate is a semisynthetic derivative of artemisinin used to treat malaria.3 It has also been shown to effective against other parasites such as liver flukes.4 Artesunate also demonstrates cytotoxic action against cancer cell lines of different tumor types.5

Using a yeast model, it has been demonstrated that Artesunate acts on the electron transport chain, generates local reactive oxygen species, and causes the depolarization of the mitochondrial membrane 1. Artesunate has been shown to inhibit TNF--induced production of proinflammatory cytokines via inhibition of NF-B and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes 2.

Packaging

100, 500 mg in poly bottle

Price and Availability

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Traditional Medicinals and Cancer

Traditional Chinese Medicine (TCM) is a healing art that has been practiced for thousands of years. The practice of TCM is a holistic approach that includes the use of herbal preparations, acupunctur...
Lynn Stephenson, Product Specialist, Sigma® Life Science and Chloe McClanahan, Product Manager, Sigma Life Science
Biofiles Vol. 8, No. 6
Keywords: Analgesics, Antitumor agents, Apoptosis, Biofiles, Cancer, Drug discovery, Formulations, Fractionation, High performance liquid chromatography, Metabolites, Metabolomics, Methods, Nuclear magnetic resonance spectroscopy, Pharmaceutical

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