Artesunate
from Artemisia annua
DOWNLOAD MSDS (PDF)-
Empirical Formula (Hill Notation) C19H28O8
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Molecular Weight 384.42
Properties
| Related Categories | Anti-Proliferative Agents, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antiparasitic / Antiprotozoal / Anthelminthic, |
| biological source | from Artemisia annua |
| storage temp. | room temp |
Description
Biochem/physiol Actions
Artesunate is a semisynthetic derivative of artemisinin used to treat malaria.1 It has also been shown to effective against other parasites such as liver flukes.2 Artesunate also demonstrates cytotoxic action against cancer cell lines of different tumor types.5
Using a yeast model, it has been demonstrated that Artesunate acts on the electron transport chain, generates local reactive oxygen species, and causes the depolarization of the mitochondrial membrane 3. Artesunate has been shown to inhibit TNF--induced production of proinflammatory cytokines via inhibition of NF-B and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes 4.
Application
Artesunate is a semisynthetic derivative of artemisinin used to treat malaria.1 It has also been shown to be effective against other parasites such as liver flukes.2
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