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A3734 Sigma

1-Azakenpaullone

≥97% (HPLC)

Synonym: 9-Bromo-7,12-dihydro-pyrido[3′,2′:2,3]azepino[4,5-b]indol-6(5H)-one

  • CAS Number 676596-65-9

  • Empirical Formula (Hill Notation) C15H10BrN3O

  • Molecular Weight 328.16

  •  MDL number MFCD09037522

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Properties

Related Categories AN-AZ, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   NTSBZVCEIVPKBJ-UHFFFAOYSA-N
assay   ≥97% (HPLC)
form   powder
storage condition   protect from light
color   gray-brown
solubility   DMSO: >10 mg/mL
storage temp.   2-8°C

Description

Caution

air sensitive

Biochem/physiol Actions

1-Azakenpaullone is a cell permeable, potent, selective inhibitor of glycogen synthase kinase 3β (GSK3β) with 100-fold less cross-reactivity against CDKs. 1-Azakenpaullone can be used together with BIO and CHIR99021 as "gold standards" for GSK3 inhibition.

Price and Availability


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All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis

Protocols & Articles

Articles

GSK-3

GSK-3 is a highly conserved family of protein kinases. In humans, two genes encode two distinct, but closely related GSK-3 forms, referred to as GSK-3α and GSK-3β. They display 84% overall identity a...
Keywords: Alzheimer Disease, Apoptosis, Atomic absorption spectroscopy, Cancer, Cardiovascular, Catalysis, Cell division, Diabetes, Diseases, Huntington Disease, Ligands, Neurodegenerative Diseases, Parkinson Disease, Phosphorylations, Schizophrenia, Transcription, Transduction

PKB/Akt

The PDK1–PKB/Akt axis represents one of the most actively researched cell signaling pathways. This protein kinase cascade is known to play a central role in mediating the actions of a range of stimul...
Keywords: Apoptosis, Atomic absorption spectroscopy, Cancer, Cell proliferation, Cell signaling, Diabetes, Gene expression, Growth factors, Inflammation, Metabolism, Myristoylations, Phosphorylations, Reversible addition-fragmentation chain transfer polymerizations

Peer-Reviewed Papers
15

References

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