Adenosine

Papers

Interspecies somatic cell nucleus transfer with porcine oocytes as recipients: A novel bioassay system for assessing the competence of canine somatic cells to develop into embryos. Sugimura, S., et al. Ther. Drug Monit. 72, 549-59, (2009)

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NMDA receptor activation increases free radical production through nitric oxide and NOX2. Helene Girouard et al J. Neurosci. 29, 2545-52, (2009)

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Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug. María P. Sánchez-Cañete et al Antimicrob. Agents Chemother. 53, 1305-13, (2009)

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Influence on Mitochondria and Cytotoxicity of Different Antibiotics Administered in High Concentrations on Primary Human Osteoblasts and Cell Lines. N. Duewelhenke, O. Krut, et al. Antimicrob. Agents Chemother. 51, 54-63, (2007)

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Binding thermodynamics as a tool to investigate the mechanisms of drug-receptor interactions: thermodynamics of cytoplasmic steroid/nuclear receptors in comparison with membrane receptors. Paola Gilli et al J. Med. Chem. 48, 2026-35, (2005)

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Are L-adenosine and its derivatives substrates for S-adenosyl-L-homocysteine hydrolase? Mengmeng Wang et al J. Med. Chem. 48, 3649-53, (2005)

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Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists. Zhan-Guo Gao et al J. Med. Chem. 49, 2689-702, (2006)

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Azadideoxyadenosine: synthesis, enzymology, and anti-HIV activity. Abdumalik A Nishonov et al Bioorg. Med. Chem. Lett. 16, 4099-101, (2006)

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Structure-based activity prediction for an enzyme of unknown function. Johannes C Hermann et al Nature 448, 775-9, (2007)

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Neuroprotective principles from Gastrodia elata. Nai-Kuei Huang et al J. Nat. Prod. 70, 571-4, (2007)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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Identification of Plasmodium falciparum spermidine synthase active site binders through structure-based virtual screening. Micael Jacobsson et al J. Med. Chem. 51, 2777-86, (2008)

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Structure-activity relationships of 7-deaza-6-benzylthioinosine analogues as ligands of Toxoplasma gondii adenosine kinase. Young Ah Kim et al J. Med. Chem. 51, 3934-45, (2008)

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Biochemical and biological properties of 5-bromotubercidin: differential effects on cellular DNA-directed and viral RNA-directed RNA synthesis. Branko Brdar et al Bioorg. Med. Chem. 16, 1481-92, (2008)

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Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase. Liqiang Chen et al Bioorg. Med. Chem. 16, 7462-9, (2008)

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Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling. Jean-Pierre Vilardaga et al Nat. Chem. Biol. 4, 126-31, (2008)

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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Naomi L Kruhlak et al Toxicol. Mech. Methods 18, 217-27, (2008)

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Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design. Williamson, D.S., et al. J. Med. Chem. 52, 1510-1513, (2009)

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Identification of critical ligand binding determinants in Mycobacterium tuberculosis adenosine-5'-phosphosulfate reductase. Jiyoung A Hong et al J. Med. Chem. 52, 5485-95, (2009)

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Novel l-adenosine analogs as cardioprotective agents. Harinath Kasiganesan et al Bioorg. Med. Chem. 17, 5347-52, (2009)

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Guide to Receptors and Channels (GRAC), 4th Edition. Br. J. Pharmacol. 158 Suppl 1, S1-254, (2009)

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Antiestrogenic constituents of the Thai medicinal plants Capparis flavicans and Vitex glabrata. Prathan Luecha et al J. Nat. Prod. 72, 1954-9, (2009)

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Inhibition of CTP synthase from Escherichia coli by xanthines and uric acids. Alexander C Roy et al Bioorg. Med. Chem. Lett. 20, 141-4, (2010)

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4-Substituted-7-N-alkyl-N-acetyl 2-aminobenzothiazole amides: drug-like and non-xanthine based A2B adenosine receptor antagonists. Adrian Wai-Hing Cheung et al Bioorg. Med. Chem. Lett. 20, 4140-6, (2010)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Striking species difference in the contribution of concentrative nucleoside transporter 2 to nucleoside uptake between mouse and rat hepatocytes. Tomomi Furihata et al Antimicrob. Agents Chemother. 54, 3035-8, (2010)

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Testing nucleoside analogues as inhibitors of Bacillus anthracis spore germination in vitro and in macrophage cell culture. Zadkiel Alvarez et al Antimicrob. Agents Chemother. 54, 5329-36, (2010)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates. Eisuke Murakami et al J. Med. Chem. 54, 5902-14, (2011)

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Discovery of benzothiazole-based adenosine A2B receptor antagonists with improved A2A selectivity. Fariborz Firooznia et al Bioorg. Med. Chem. Lett. 21, 1933-6, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A?A adenosine receptor. Francesca Deflorian et al J. Med. Chem. 55, 538-52, (2012)

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Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli purine nucleoside phosphorylase: palladium mediated cross-coupling of organozinc halides with 6-chloropurine nucleosides. Abdalla E A Hassan et al Eur. J. Med. Chem. 47, 167-74, (2012)

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A₁ adenosine receptor agonists: medicinal chemistry and therapeutic potential. Hutchinson, S.A., and Scammells, P.J. Curr. Pharm. Des. 10, 2021-2039, (2004)

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Actions of Adenosine at Its Receptors in the CNS: Insights from Knockouts and Drugs. Fredholm, B.B., et al. Annu. Rev. Pharmacol. 27, (2004)

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Adenosine, inflammation and asthma--a review. Livingston, M., et al. Inflamm. Res. 53, 171-178, (2004)

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Adenosine A_2A receptor agonists as anti-inflammatory agents. Sullivan, G.W. Curr. Opin. Investig. Drugs 4, 1313-1319, (2003)

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Targeting adenosine receptors: novel therapeutic targets in asthma and chronic obstructive pulmonary disease. Rorke, S. and Holgate S.T. Am. J. Respir. Med. 1, 99-105, (2002)

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Merck 14,153

Beil. 26,IV,3598

FT-IR 1 (2), 720:A / FT-IR 2 (3), 3684:C / FT-NMR 1 (3), 222:A / IR-Spectra (3), 1296:E / IR-Spectra (2), 1128:F / NMR-Reference 2 (2), 597:C / RegBook 1 (2), 2475:K / Sax 6, 138 / Sigma FT-IR 1 (1), 752:C / Structure Index 1, 391:A:6