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A4142 Sigma

Azaserine

≥98% (TLC)

Synonym: O-Diazoacetyl-L-serine

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Properties

Related Categories Amino Acid Derivatives, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application,
InChI Key   MZZGOOYMKKIOOX-VKHMYHEASA-N
assay   ≥98% (TLC)
Mode of action   enzyme | inhibits
antibiotic activity spectrum   fungi
storage temp.   −20°C

Description

Application

Used in cell culture for the selection of HGPRT revertants.

Packaging

50, 250 mg in glass bottle

Biochem/physiol Actions

Azaserine is an antibiotic and antifungal; it may also act as a tumor inducer. It is a structural analog of glutamine and competes with glutamine in binding to enzymes involved in purine biosynthesis. Azaserine inhibits purine biosynthesis by covalently reacting with cysteine residues in the enzyme active sites, such as in formylglycinamide ribonucleotide amidotransferase and PRPP amidotransferase. Azaserine can induce DNA damage via the formation of carboxymethylated bases and O6-methylguanine. Secretion of exo-1,3-β-glucanase and germ-tube formation of Candida albicans were inhibited by azaserine.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3462 6.1 / PGIII
WGK Germany 
3
RTECS 
VT9625000
Protocols & Articles

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Peer-Reviewed Papers
15

References

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