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A4233 Sigma

Ara-G hydrate

≥98% (HPLC), solid

Synonym: 9-β-D-Arabinofuranosyl guanine hydrate

Properties

Related Categories AN-AZ, Apoptosis Inducers, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Biology,
assay   ≥98% (HPLC)
form   solid
solubility   DMSO: >10 mg/mL
  H2O: insoluble
storage temp.   2-8°C

Description

Application

Ara-G is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. This active form of Ara-G induces apoptosis and inhibits DNA synthesis. Ara-G is also an antineoplastic and antimetabolite.

Biochem/physiol Actions

Ara-G is an inducer of apoptosis; inhibitor of DNA synthesis; antineoplastic; and antimetabolite. Ara-G is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. Incorporation of Ara-GTP into DNA leads to inhibition of DNA synthesis and apoptosis.

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