|Related Categories||AN-AZ, Apoptosis Inducers, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Biology,|
|solubility||DMSO: >10 mg/mL|
Ara-G is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. This active form of Ara-G induces apoptosis and inhibits DNA synthesis. Ara-G is also an antineoplastic and antimetabolite.
Ara-G is an inducer of apoptosis; inhibitor of DNA synthesis; antineoplastic; and antimetabolite. Ara-G is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. Incorporation of Ara-GTP into DNA leads to inhibition of DNA synthesis and apoptosis.
|Precautionary statements||P261-P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xn|
|Risk Statements (Europe)||22-36/37/38|
|Safety Statements (Europe)||26|
Induction of fetal hemoglobin and ABCB1 gene expression in 9-β-D-arabinofuranosylguanine-resistant MOLT-4 cells. Fyrberg A, Peterson C, Kågedal B, et al. Cancer Chemother. Pharmacol. 68(3), 583-91, (2011)
Activation of guanine-β-D-arabinofuranoside and deoxyguanosine to triphosphates by a common pathway blocks T lymphoblasts at different checkpoints. Leanza L, Miazzi C, Ferraro P, et al. Exp. Cell Res. 316(20), 3443-53, (2010)
The novel nucleoside transport system exhibited by NB4 cells, csg, transports deoxyguanosine analogues, including ara-G. Flanagan SA, Gandhi V, Secrist JA, et al. Biochem. Pharmacol. 66(5), 733-7, (2003)
Low level of mitochondrial deoxyguanosine kinase is the dominant factor in acquired resistance to 9-beta-D-arabinofuranosylguanine cytotoxicity. Lotfi K, Månsson E, Peterson C, et al. Biochem. Biophys. Res. Commun. 293(5), 1489-96, (2002)
Differential incorporation of 1-beta-D-arabinofuranosylcytosine and 9-beta-D-arabinofuranosylguanine into nuclear and mitochondrial DNA. Zhu C, Johansson M, and Karlsson A FEBS Lett. 474(2-3), 129-32, (2000)
Pharmacokinetics of nelarabine and 9-beta-D-arabinofuranosyl guanine in pediatric and adult patients during a phase I study of nelarabine for the treatment of refractory hematologic malignancies. Kisor DF, Plunkett W, Kurtzberg J, et al. J. Clin. Oncol. 18(5), 995-1003, (2000)
Synthesis of 2'-deoxy-2'-[18F]fluoro-9-β-D-arabinofuranosylguanine: a novel agent for imaging T-cell activation with PET. Namavari M, Chang YF, Kusler B, et al. Mol. Imaging Biol. 13(5), 812-8, (2011)
A new high-performance liquid chromatography method determines low production of 9-beta-D-arabinofuranosylguanine triphosphate, an active metabolite of nelarabine, in adult T-cell leukemia cells. Yamauchi T, Nishi R, Kitazumi K, et al. Oncol. Rep. 23(2), 499-504, (2010)
Resistance to mitochondrial- and Fas-mediated apoptosis in human leukemic cells with acquired resistance to 9-beta-D-arabinofuranosylguanosine. Månsson E, Stridh H, and Albertioni F Biochem. Biophys. Res. Commun. 298(3), 338-44, (2002)
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