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A4377 Sigma

S-(5′-Adenosyl)-L-methionine iodide

from yeast, ≥80% (HPLC), ≥80% (spectrophotometric assay)

Synonym: AdoMet, SAM

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Properties

Related Categories A - H, Amino Acids, Biochemicals and Reagents, Modified Amino Acids
biological source   from yeast
InChI Key   XQMWYLXPEGFCFT-XKGORWRGSA-N
assay   ≥80% (HPLC)
  ≥80% (spectrophotometric assay)
solubility   H2O: soluble100 mg/mL
shipped in   dry ice
storage temp.   −20°C

Description

Analysis Note

Purity based on UV and HPLC.

Biochem/physiol Actions

Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.

Caution

This material is very unstable at room temperature.

Packaging

5, 25, 100 mg in glass bottle

Application

S-(5′-Adenosyl)-L-methionine (SAM, AdoMet) is used as a primary methyl donor molecule in mammalian cell culture and the first step metabolite in methionine biosynthesis.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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Description

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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