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A4403 Sigma

L-Ascorbic acid

powder, cell culture tested, γ-irradiated

Synonym: L-Threoascorbic acid, Antiscorbutic factor, Vitamin C

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Properties

Related Categories Amino Acids & Vitamins, Amino Acids and Vitamins, Biochemicals and Reagents, Cell Culture, Core Bioreagents,
InChI Key   CIWBSHSKHKDKBQ-JLAZNSOCSA-N
sterility   γ-irradiated
form   powder
color   white to off-white
pH   1.0 - 2.5 (25 °C, 176 g/L in water)
mp   190-194 °C (dec.)
solubility   H2O: soluble10 mg/mL
suitability   cell culture tested
Gene Information   human ... SLC23A2(9962)

Description

Application

For use in cell culture applications as an antioxidant and to regenerate tocopherol.
L-ascorbic acid has been used:
• in an osteogenic supplement for the growth of cells
• as a component in the differentiation media
• in WS-MSCs (Werner syndrome-mesenchymal stem cells) to study rescuing properties of ascorbic acid on aging defects

Biochem/physiol Actions

L-ascorbic acid mainly exhibits antioxidant properties. It protects plants from oxidative stress and mammals from diseases associated with oxidative stress. L-ascorbic acid mainly protects from hydroxyl radicals, superoxide and singlet oxygen. In addition, it also reduces the membrane-linked antioxidant α-tocopherol (oxidised form). L-Ascorbic acid enhances endothelium-dependent vasodilation in various disorders, including diabetes, coronary artery disease, hypertension and chronic heart failure.

General description

L-ascorbic acid is an unsaturated γ-lactone ring containing an enediol configuration (–COH=COH) attached with a carbonyl group.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
CI7650000
Protocols & Articles

Related Content

Ascorbate in Cell Culture

Importance and uses of ascorbate in serum-free eucaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures
Keywords: Cell culture, Culture media, Hydroxylations, Lipid peroxidation, Metabolism, Peroxidations, Vitamins

Peer-Reviewed Papers
15

References

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