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  • A4470 - Monoclonal Anti-Adenovirus 2 E1A (Adenovirus 2 early region 1) antibody produced in mouse

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A4470 Sigma

Monoclonal Anti-Adenovirus 2 E1A (Adenovirus 2 early region 1) antibody produced in mouse

~0.5 mg/mL, clone M73, purified immunoglobulin, buffered aqueous solution

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Properties

Related Categories AD-AD, Alphabetical Index, Antibodies, Antibodies for Aids and Viral Research, Antibodies for Apoptosis,
biological source   mouse
antibody form   purified immunoglobulin
clone   M73, monoclonal
form   buffered aqueous solution
mol wt   antigen mol wt 30-50 kDa (3 bands)
species reactivity   viral
concentration   ~0.5 mg/mL
application(s)   immunoprecipitation: 1-2 μg/mL using whole extract of HEK 293 cells
  indirect immunofluorescence: 2-5 μg/mL
isotype   IgG2a
conjugate   unconjugated
shipped in   dry ice
storage temp.   −20°C

Description

Immunogen

full length recombinant adenovirus 2 E1A protein.

Physical form

Solution in phosphate buffered saline, pH 7.4, containing 0.08% sodium azide.

Application

Monoclonal Anti-Adenovirus 2 E1A can be used for indirect immunofluorescence (2-5μg/mL) and immunoprecipitation (1-2μg/mL, using whole extract of HEK 293 cells).

General description

Adenovirus E1A gene modulates gene expression by associating with transcription factors in cells. Studies have reported that E1A regulates the stimulation of ICAM-1 through inflammatory signals in pulmonary epithelial cells. E1A has also been implicated in chronic obstructive pulmonary disease (COPD). Furthermore, E1A is known to mediate tumor suppression by rendering epithelial cells sensitive to anoikis. Mouse Monoclonal Anti-Adenovirus 2 E1A antibody binds to adenovirus 2 and 5 E1A (3 bands at 30-50kDa by SDS-PAGE), as well as E1A associated proteins.

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