|Related Categories||Amiloride and Derivatives, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DIG-DY,|
human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548)|
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a2(24783), Slc9a3(24784)
Selective blocker of Na+/H+ antiport; IC50 = 6.9 μM.
5-(N,N-Dimethyl)amiloride hydrochloride is a selective blocker of Na2/H+ antiport. 5-(N,N-Dimethyl)amiloride hydrochloride has been investigated for its ability to reduce inflammatory pain.
Certificate of Analysis
Effect of 5-(N,N-Dimethyl)-amiloride, a specific inhibitor of Na(+)/H(+) exchanger, on the palmitoyl-L-carnitine-induced mechanical and metabolic derangements in the isolated perfused rat heart. Arakawa, J. and Hara, A. Pharmacology 59, 239, (1999)
Hypericin-induced phototoxicity of human leukemic cell line HL-60 is potentiated by omeprazole, an inhibitor of H+K+-ATPase and 5'-(N,N-dimethyl)-amiloride, an inhibitor of Na+/H+ exchanger. Mirossay, L., et al. Physiol. Res. 48, 135, (1999)
Elevated hydrostatic pressure activates sodium/hydrogen exchanger-1 in rat optic nerve head astrocytes. Mandal A, Shahidullah M, Delamere NA, et al. Am. J. Physiol. Cell Physiol. 297(1), C111-20, (2009)
Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3. Musch MW, Arvans DL, Wu GD, et al. Am. J. Physiol. Gastrointest. Liver Physiol. 296(2), G202-10, (2009)
Inhibition of Na+/H+ exchanger enhances low pH-induced L-selectin shedding and beta2-integrin surface expression in human neutrophils. Kaba NK, Schultz J, Law FY, et al. Am. J. Physiol. Cell Physiol. 295(5), C1454-63, (2008)
Functional identification of a novel transport system for endogenous and synthetic opioid peptides in the rabbit conjunctival epithelial cell line CJVE. Ananth S, Karunakaran S, Martin PM, et al. Pharm. Res. 26(5), 1226-35, (2009)
Intracellular mechanisms and receptor types for endothelin-1-induced positive and negative inotropy in mouse ventricular myocardium. Namekata I, Fujiki S, Kawakami Y, et al. Naunyn Schmiedebergs Arch. Pharmacol. 376(6), 385-95, (2008)
Protection of ischaemic-reperfused rat heart by dimethylamiloride is associated with inhibition of mitochondrial permeability transition. Prendes MG, Torresín E, González M, et al. Clin. Exp. Pharmacol. Physiol. 35(2), 201-6, (2008)
Electron microprobe analysis of rabbit ciliary epithelium indicates enhanced secretion posteriorly and enhanced absorption anteriorly. McLaughlin CW, Zellhuber-McMillan S, Macknight AD, et al. Am. J. Physiol. Cell Physiol. 293(5), C1455-66, (2007)
Mechanisms of secretion-associated shrinkage and volume recovery in cultured rabbit parietal cells. Bachmann O, Heinzmann A, Mack A, et al. Am. J. Physiol. Gastrointest. Liver Physiol. 292(3), G711-7, (2007)
[Effect of the NHE-1-specific inhibitor DMA on pHi, proliferation and apoptosis of HL-60/ADM cells in vitro]. Chang C, Kong PY, Chen XH, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 14(3), 488-91, (2006)
Influence of fasting on the effects of dimethylamiloride and oxfenicine on ischaemic-reperfused rat hearts. Marina Prendes MG, García JV, Testoni G, et al. Arch. Physiol. Biochem. 112(1), 31-6, (2006)
Studies on the mechanisms underlying amiloride enhancement of 3,4-methylenedioxymethamphetamine-induced serotonin depletion in rats. Goñi-Allo B, Puerta E, Hervias I, et al. Eur. J. Pharmacol. 562(3), 198-207, (2007)
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