• USA Home
  • A4781 - Asialofetuin from fetal calf serum

EMAIL THIS PAGE TO A FRIEND
A4781 Sigma

Asialofetuin from fetal calf serum

Type I (Sigma designation)

Purchase

Properties

Related Categories Application Index, Biochemicals and Reagents, Enzymes, Inhibitors, and Substrates, Fetuin, Plasma & Blood Proteins,
Quality Level   PREMIUM
type   Type I (Sigma designation)
impurities   salt, essentially free
  ≤0.5% N-acetylneuraminic acid
solubility   0.85% sodium chloride: soluble1 mg/mL
storage temp.   2-8°C

Description

Application

Incorporation of asialofetuin (AF) in liposomes strongly enhance delivery to and endocytosis by cells displaying the AF receptor, notably hepatocytes. This provides a very efficient route for gene therapy.

Incorporation of asialofetuin (AF) in liposomes strongly enhance delivery and endocytosis by cells displaying the AF receptor, such as the hepatocytes. This provides a very efficient route for gene therapy. Asialofetuin was used to study the nature of the interaction between ferritin and the placenta.

Packaging

1 g in poly bottle

50, 250 mg in poly bottle

Preparation Note

Prepared by a modification of Spiro, R.G., J. Biol. Chem., 235, 2860 (1960).

Biochem/physiol Actions

Asialofetuin exhibits affinity to asialoglycoprotein receptor (ASGP-R) on hepatocytes and uses the receptor to enter the cell. This property allows asialofetuin to be used as a ligand to deliver drugs to hepatocytes and as a competitive inhibitor to ASGP-R.

General description

Asialofetuin is a glycoprotein with three asparagine-linked triantennary complex carbohydrate chains and terminal N-acetylgalactosamine residues.

Price and Availability


Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Plasma Derived Proteins and Enzymes

Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Applications, Gas chromatography, Type

Peer-Reviewed Papers
15

References

Related Products

related product

Product #

Description

Add to Cart

08168 Timestrip Plus 8 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?