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A4847 Sigma

Alsterpaullone

≥98% (HPLC), powder

Synonym: 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one

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Properties

Related Categories A to C, A-AM, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents,
InChI Key   OLUKILHGKRVDCT-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   yellow to brown
solubility   DMSO: ≥10 mg/mL
storage temp.   2-8°C
Gene Information   rat ... Gsk3b(84027)

Description

Biochem/physiol Actions

Potent and selective inhibitor of GSK-3β and CDK5/p25; potent inhibitor of CDK1/cyclin B (IC50 = 0.035 μM).

Application

Alsterpaullone inhibits GSK-3β, CDK5/p25, and CDK1/cyclin B. Alsterpaullone has also been studied as an antimanic therapeutic for the acute manic phase of bipolar disorder.

Features and Benefits

This compound is featured on the CDKs and GSK-3 pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Price and Availability

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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