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A4882 Sigma

6-Thioguanine

≥98%

Synonym: 2-Amino-6-mercaptopurine, 2-Amino-6-purinethiol

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Properties

Related Categories Antitumor Agents, Cancer Research, Cell Biology, DNA Synthesis Inhibitors
InChI Key   WYWHKKSPHMUBEB-UHFFFAOYSA-N
assay   ≥98%
mp   ≥300 °C(lit.)

Description

Biochem/physiol Actions

Antimetabolite used in the treatment of leukemias. Competes with hypoxanthine and guanine for the enzyme hypoxanthine-guanine phosphoribosyltransferase, which catalzyes a critical step in the generation of purine nucleotides.

Ribosylated and phosphorylated by the same pathway as natural purine bases; as the nucleotide, inhibits a variety of cellular processes involved in nucleic acid synthesis. Has a long history as an effective treatment of leukemia.

Packaging

1, 5 g in glass bottle

100, 250, 500 mg in glass bottle

Price and Availability


All labs need water
Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
UP0740000
Protocols & Articles

Articles

Nucleotide Synthesis in Cancer Cells

Neoplastic cells are highly dependent on the de novo synthesis of nucleotides to maintain sufficient pools to support DNA replication and the production of RNA. The metabolic pathways supporting nucl...
Keywords: Biofiles, Cancer, Catalysis, Citric Acid Cycle, DNA replication, Gene expression, Glycolysis, Metabolic Pathways, Metabolism, Metabolites, Nucleotide Synthesis, PAGE, Pentose phosphate pathway, Pyrimidine synthesis, Support

Peer-Reviewed Papers
15

References

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