Monoclonal Anti-β-Amyloid antibody produced in mouse
clone BAM-10, ascites fluid
DOWNLOAD MSDS (PDF)Synonym: Anti-A-BETA, Anti-Amyloid β Precursor Protein, Clone BAM91
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MDL number MFCD00803867
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Popular Documents: Datasheet (PDF)
Properties
| Related Categories | AM-AN, Alphabetical Index, Antibodies, Antibodies for Alzheimer′s Disease, Antibodies for Neurobiology, |
| species reactivity | human |
| application(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:2,000 using formic acid-treated, formalin-fixed, human Alzheimer′s disease (AD) brain sections. |
| indirect ELISA: suitable | |
| clone | BAM-10, monoclonal |
| antibody form | ascites fluid |
| isotype | IgG1 |
| contains | 15 mM sodium azide |
| shipped in | dry ice |
| storage temp. | −20°C |
Description
Immunogen
synthetic β-amyloid peptide (1-40), conjugated to KLH.
Specificity
The antibody is useful in immunohistochemistry, immunoblotting,2 ELISA, and competitive ELISA. Also, this antibody has been used to neutralize Aβ assemblies in brains of transgenic mice expressing a mutant form of amyloid precursor protein,3 and for in vivo deep tissue imaging using near-IR optical spectrum.4
The antibody reacts specifically with β-amyloid protein. The epitope recognized by the antibody resides within amino acids 1-12 of the β-amyloid protein. It specifically stains amyloid plaques within the cortex and amyloid deposits in blood vessels using formic acid-treated, formalin-fixed, paraffin-embedded, and Methacarn-fixed sections of human Alzheimer′s disease (AD) brain tissue.
Application
Mouse monoclonal anti-ABETA was used to treat old WT PDAPP mice with amyloid accumulation and learning deficits in an attempt to improve learning and decrease accumulatin however no response was observed.
Mouse monoclonal anti-ABETA was used to treat old WT PDAPP mice with amyloid accumulation and learning deficits in an attempt to improve learning and decrease accumulatin however no response was observed.1
Price and Availability
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