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A5376 Sigma

Acetylsalicylic acid

≥99.0%, crystalline

Synonym: 2-Acetoxybenzoic acid, O-Acetylsalicylic acid, ASA, Aspirin

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Properties

Related Categories A to C, Application Index, Arachidonic Acid Cascade, Biochemicals and Reagents, Cancer Research,
assay   ≥99.0%
form   crystalline
color   white
pKa (25 °C)   3.5
mp   134-136 °C(lit.)
solubility   H2O: soluble10 mg/mL at 37 °C(lit.)
  H2O: soluble3 mg/mL at 25 °C(lit.)
  ethanol: soluble50 mg/mL
  aqueous base: decomposes
absorption   ε1mM/230 nm, aqueous acid 466
  ε1mM/231 nm, aqueous base 409
  ε1mM/278 nm, aqueous acid 68
  ε1mM/298 nm, aqueous base 190
Gene Information   human ... ITGA2B(3674), ITGB3(3690), PTGS1(5742), PTGS2(5743)

Description

Frequently Asked Questions

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Biochem/physiol Actions

Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.

Packaging

1 kg in poly bottle

100, 250, 500 g in poly bottle

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
WGK Germany 
1
RTECS 
VO0700000
Flash Point(F) 
482 °F
Flash Point(C) 
250 °C

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

Differential effects of inhibitors of cyclooxygenase (COX-1 and COX-2) in acute inflammation. Gilroy, D. W., et al. Eur. J. Pharmacol. 355, 211-217, (1998)

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Differential effects of inhibition of isoforms of cyclooxygenase (COX-1 and COX-2) in chronic inflammation. Gilroy, D. W. Inflamm. Res. 47, 79, (1998)

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Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis. Schror, K. Semin. Thromb. Hemost. 23, 349-356, (1997)

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Cyclooxygenase inhibitors: drugs for cancer prevention. Shiff, S.J., et al. Curr. Opin. Pharmacol. 3, 352-361, (2003)

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Aspirin in patients undergoing noncardiac surgery. Devereaux PJ, Mrkobrada M, Sessler DI, et al. N. Engl. J. Med. 370(16), 1494-503, (2014)

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Platelet reactivity and clinical outcomes after coronary artery implantation of drug-eluting stents (ADAPT-DES): a prospective multicentre registry study. Stone GW, Witzenbichler B, Weisz G, et al. Lancet 382(9892), 614-23, (2013)

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Aspirin use and risk of colorectal cancer according to BRAF mutation status. Nishihara R, Lochhead P, Kuchiba A, et al. JAMA 309(24), 2563-71, (2013)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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Effects of a fixed-dose combination strategy on adherence and risk factors in patients with or at high risk of CVD: the UMPIRE randomized clinical trial. Thom S, Poulter N, Field J, et al. JAMA 310(9), 918-29, (2013)

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Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin. Niels Hulsman et al J. Med. Chem. 50, 2424-31, (2007)

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Dose- and time-dependent antiplatelet effects of aspirin. Perneby C, Wallén NH, Rooney C, et al. Thromb. Haemost. 95(4), 652-8, (2006)

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Efficacy of aspirin for the primary prevention of thrombosis in patients with antiphospholipid antibodies: an international and collaborative meta-analysis. Arnaud L, Mathian A, Ruffatti A, et al. Autoimmun. Rev. 13(3), 281-91, (2014)

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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Gustav Ahlin et al J. Med. Chem. 51, 5932-42, (2008)

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Platelet response to low-dose enteric-coated aspirin in patients with stable cardiovascular disease. Maree AO, Curtin RJ, Dooley M, et al. J. Am. Coll. Cardiol. 46(7), 1258-63, (2005)

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Enhanced antiplatelet effect of clopidogrel in patients whose platelets are least inhibited by aspirin: a randomized crossover trial. Eikelboom JW, Hankey GJ, Thom J, et al. J. Thromb. Haemost. 3(12), 2649-55, (2005)

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Characterization of the drug binding specificity of rat liver fatty acid binding protein. Sara Chuang et al J. Med. Chem. 51, 3755-64, (2008)

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Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases. P N Praveen Rao et al J. Med. Chem. 49, 1668-83, (2006)

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Guide to Receptors and Channels (GRAC), 4th Edition. Br. J. Pharmacol. 158 Suppl 1, S1-254, (2009)

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Cyclooxygenase-1 haplotype modulates platelet response to aspirin. Maree AO, Curtin RJ, Chubb A, et al. J. Thromb. Haemost. 3(10), 2340-5, (2005)

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Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies. Carlos Velázquez et al J. Med. Chem. 48, 4061-7, (2005)

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Second-generation aspirin and indomethacin prodrugs possessing an O(2)-(acetoxymethyl)-1-(2-carboxypyrrolidin-1-yl)diazenium-1,2-diolate nitric oxide donor moiety: design, synthesis, biological evaluation, and nitric oxide release studies. Carlos A Velázquez et al J. Med. Chem. 51, 1954-61, (2008)

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Design and rationale for the Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54 (PEGASUS-TIMI 54) trial. Bonaca MP, Bhatt DL, Braunwald E, et al. Am. Heart J. 167(4), 437-444.e5, (2014)

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Expanding the ChemGPS chemical space with natural products. Josefin Larsson et al J. Nat. Prod. 68, 985-91, (2005)

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Risk of upper gastrointestinal bleeding from different drug combinations. Masclee GM, Valkhoff VE, Coloma PM, et al. Gastroenterology 147(4), 784-792.e9; quiz e13-4, (2014)

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Management of acute limb ischemia in the pediatric population. Kayssi A, Shaikh F, Roche-Nagle G, et al. J. Vasc. Surg. 60(1), 106-10, (2014)

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Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis. Toshiyuki Harada et al Bioorg. Med. Chem. 17, 149-64, (2009)

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Aspirin therapy in primary cardiovascular disease prevention: a position paper of the European Society of Cardiology working group on thrombosis. Halvorsen S, Andreotti F, ten Berg JM, et al. J. Am. Coll. Cardiol. 64(3), 319-27, (2014)

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O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies. Carlos A Velázquez et al Bioorg. Med. Chem. 15, 4767-74, (2007)

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The relationships among physician and hospital volume, processes, and outcomes of care for acute myocardial infarction. Tung YC, Chang GM, Chien KL, et al. Med. Care 52(6), 519-27, (2014)

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Protein kinase C[δ] differentially regulates platelet functional responses. Ramya Chari et al Arterioscler. Thromb. Vasc. Biol. 29, 699-705, (2009)

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Anticoagulant medication at time of needle biopsy for breast cancer in relation to risk of lymph node metastasis. Ljung R, Sennerstam R, Mattsson F, et al. Int. J. Cancer 135(1), 238-41, (2014)

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Beyond aspirin-cancer prevention with statins, metformin and bisphosphonates. Gronich N and Rennert G Nat. Rev. Clin. Oncol. 10(11), 625-42, (2013)

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Synthesis and pharmacological evaluation of 1H-imidazoles as ligands for the estrogen receptor and cytotoxic inhibitors of the cyclooxygenase. Thomas Wiglenda et al J. Med. Chem. 48, 6516-21, (2005)

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Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors. Hiroko Sano et al Bioorg. Med. Chem. Lett. 16, 3068-72, (2006)

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The gap between guidelines and reality: Type 2 diabetes in a National Diabetes Register 1996-2003. Eliasson B, Cederholm J, Nilsson P, et al. Diabet. Med. 22(10), 1420-6, (2005)

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Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bram Baert et al Bioorg. Med. Chem. 15, 6943-55, (2007)

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Statins, aspirin and risk of thromboembolic events in ovarian cancer patients. Shai A, Rennert HS, Rennert G, et al. Gynecol. Oncol. 133(2), 304-8, (2014)

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Isosorbide-based aspirin prodrugs: integration of nitric oxide releasing groups. Michael Jones et al J. Med. Chem. 52, 6588-98, (2009)

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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. R Scott Obach et al Drug Metab. Dispos. 36, 1385-405, (2008)

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Searching for new NO-donor aspirin-like molecules: a new class of nitrooxy-acyl derivatives of salicylic acid. Loretta Lazzarato et al J. Med. Chem. 51, 1894-903, (2008)

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Modification of outcomes with aspirin or apixaban in relation to female and male sex in patients with atrial fibrillation: a secondary analysis of the AVERROES study. Lip GY, Eikelboom J, Yusuf S, et al. Stroke 45(7), 2127-30, (2014)

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Physicochemical determinants of human renal clearance. Manthena V S Varma et al J. Med. Chem. 52, 4844-52, (2009)

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Impact--the cone and plate(let) analyzer: testing platelet function and anti-platelet drug response. Savion N and Varon D Pathophysiol. Haemost. Thromb. 35(1-2), 83-8, (2006)

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Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. Morshed Alam Chowdhury et al Bioorg. Med. Chem. Lett. 18, 6138-41, (2008)

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Prevalence of high on-treatment platelet reactivity in diabetic patients treated with aspirin. Simpson SH, Abdelmoneim AS, Omran D, et al. Am. J. Med. 127(1), 95.e1-9, (2014)

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Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies. Morshed A Chowdhury et al Bioorg. Med. Chem. Lett. 20, 1324-9, (2010)

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Evidence-based management of Kawasaki disease in the emergency department. Seaton KK and Kharbanda A Pediatr. Emerg. Med. Pract. 12(1), 1-20; quiz 21, (2015)

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[Giant cell arteritis--old questions, current answers]. Bnaya A, Nesher G, Sonenblick M, et al. Harefuah 153(12), 747-50, 751, (2014)

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Chocolate consumption and risk of diabetes mellitus in the Physicians' Health Study. Matsumoto C, Petrone AB, Sesso HD, et al. Am. J. Clin. Nutr. 101(2), 362-7, (2015)

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Polycythemia vera and essential thrombocythemia: 2015 update on diagnosis, risk-stratification and management. Tefferi A and Barbui T Am. J. Hematol. 90(2), 162-73, (2015)

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The role of the cardiologist in the primary prevention of cardiovascular disease with aspirin. Verheugt FW J. Am. Coll. Cardiol. 65(2), 122-4, (2015)

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Frequency and practice-level variation in inappropriate aspirin use for the primary prevention of cardiovascular disease: insights from the National Cardiovascular Disease Registry's Practice Innovation and Clinical Excellence registry. Hira RS, Kennedy K, Nambi V, et al. J. Am. Coll. Cardiol. 65(2), 111-21, (2015)

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More evidence that aspirin lowers cancer risk. Sinha G J. Natl. Cancer Inst. 107(1), 495, (2015)

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Orally given gastroprotective capsaicin does not modify aspirin-induced platelet aggregation in healthy male volunteers (human phase I examination). Sandor B, Papp J, Mozsik G, et al. Acta Physiol. Hung. 101(4), 429-37, (2014)

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Is aspirin a dangerous drug? JAMA 312(23), 2577, (2014)

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The consult guys--balancing the medication portfolio 5 years after a heart attack. Merli GJ and Weitz HH Ann. Intern. Med. 161(12), CG12, (2014)

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Net clinical benefit of antithrombotic therapy in patients with atrial fibrillation and chronic kidney disease: a nationwide observational cohort study. Bonde AN, Lip GY, Kamper AL, et al. J. Am. Coll. Cardiol. 64(23), 2471-82, (2014)

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Effects of long-term blood pressure lowering and dual antiplatelet treatment on cognitive function in patients with recent lacunar stroke: a secondary analysis from the SPS3 randomised trial. Pearce LA, McClure LA, Anderson DC, et al. Lancet Neurol. 13(12), 1177-85, (2014)

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Blood pressure control after stroke: too little, too late, or too soon to tell? Hillis AE Lancet Neurol. 13(12), 1162-3, (2014)

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Antiplatelet therapy as sole anticoagulant in patients with aortic mechanical prostheses. García-Rinaldi R J. Thorac. Cardiovasc. Surg. 148(6), 3255-6, (2014)

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You can't get there from here without more robust data. Body S and Couper G J. Thorac. Cardiovasc. Surg. 148(6), 3125-6, (2014)

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Aspirin and COX-2 inhibitor use in patients with stage III colon cancer. Ng K, Meyerhardt JA, Chan AT, et al. J. Natl. Cancer Inst. 107(1), 345, (2015)

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When should aspirin be used for prevention of cardiovascular events? Gaziano JM and Greenland P JAMA 312(23), 2503-4, (2014)

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Low-dose aspirin for primary prevention of cardiovascular events in Japanese patients 60 years or older with atherosclerotic risk factors: a randomized clinical trial. Ikeda Y, Shimada K, Teramoto T, et al. JAMA 312(23), 2510-20, (2014)

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Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents. Mauri L, Kereiakes DJ, Yeh RW, et al. N. Engl. J. Med. 371(23), 2155-66, (2014)

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Dual antiplatelet therapy after drug-eluting stents--how long to treat? Colombo A and Chieffo A N. Engl. J. Med. 371(23), 2225-6, (2014)

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Prevention of acute kidney injury using vasoactive or antiplatelet treatment: three strikes and out? Winkelmayer WC and Finkel KW JAMA 312(21), 2221-2, (2014)

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Perioperative aspirin and clonidine and risk of acute kidney injury: a randomized clinical trial. Garg AX, Kurz A, Sessler DI, et al. JAMA 312(21), 2254-64, (2014)

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Cohort study of corticosteroid use and risk of hospital admission for diverticular disease. Hjern F, Mahmood MW, Abraham-Nordling M, et al. Br. J. Surg. 102(1), 119-24, (2015)

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Kawasaki shock syndrome complicating a recurrence of Kawasaki disease. Tissandier C, Lang M, Lusson JR, et al. Pediatrics 134(6), e1695-9, (2014)

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Occurrence of the JAK2 V617F mutation in patients with peripheral arterial disease. Muendlein A, Kinz E, Gasser K, et al. Am. J. Hematol. 90(1), E17-21, (2015)

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Platelet function assays--not all are created equal. Chandler WL Clin. Chem. 60(12), 1469-70, (2014)

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Weighing the risks of perioperative aspirin. Serak J and Wang MY World Neurosurg. 82(6), 928-9, (2014)

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Resistance to antiplatelet drugs: what progress has been made? Tantry US, Gesheff M, Liu F, et al. Expert Opin. Pharmacother. 15(17), 2553-64, (2014)

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Precision and reliability of 5 platelet function tests in healthy volunteers and donors on daily antiplatelet agent therapy. Karon BS, Tolan NV, Koch CD, et al. Clin. Chem. 60(12), 1524-31, (2014)

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Discussion. Surgery 156(4), 1026-8, (2014)

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Predictors of contemporary coronary artery bypass grafting outcomes. Weisel RD, Nussmeier N, Newman MF, et al. J. Thorac. Cardiovasc. Surg. 148(6), 2720-6.e1-2, (2014)

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Prostaglandin D₂: a dominant mediator of aspirin-exacerbated respiratory disease. Cahill KN, Bensko JC, Boyce JA, et al. J. Allergy Clin. Immunol. 135(1), 245-52, (2015)

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Platelet dysfunction and platelet transfusion in traumatic brain injury. Briggs A, Gates JD, Kaufman RM, et al. J. Surg. Res. 193(2), 802-6, (2015)

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Aspirin and nonsteroidal anti-inflammatory drug use and the risk of Barrett's esophagus. Schneider JL, Zhao WK, and Corley DA Dig. Dis. Sci. 60(2), 436-43, (2015)

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Assessment of platelet function with light transmission aggregometry in 24 patients supported with a continuous-flow left ventricular assist device: a single-center experience. Fiore M, James C, Mouton C, et al. J. Thorac. Cardiovasc. Surg. 148(6), 3119-25.e1, (2014)

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New ways to assess stroke risk and tame an abnormal heartbeat. Cardiology groups update guidelines to treat atrial fibrillation. Johns Hopkins Med. Lett. Health After 50 26(6), 1-2, (2014)

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Colchicine for pericarditis. Alabed S, Cabello JB, Irving GJ, et al. Cochrane Database Syst. Rev. 8, CD010652, (2014)

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NICE rules against aspirin in AF patients. Nurs. Times 110(27), 4, (2014)

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Aspirin as adjunctive treatment for giant cell arteritis. Mollan SP, Sharrack N, Burdon MA, et al. Cochrane Database Syst. Rev. 8, CD010453, (2014)

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[Taking aspirin for prevention of "traveler's thrombosis"?]. Stiefelhagen P Med. Monatsschr. Pharm. 37(7), 259-60, (2014)

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Modulation of age- and cancer-associated DNA methylation change in the healthy colon by aspirin and lifestyle. Noreen F, Röösli M, Gaj P, et al. J. Natl. Cancer Inst. 106(7), doi:10.1093/jnci/dju161, (2014)

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5 simple steps that may help prevent colorectal cancer. Screenings, exercise, and vitamin D may reduce your risks. Harv. Health Lett. 39(6), 5, (2014)

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Ask the doctor. Is it okay to take both aspirin and ibuprofen therapies? Komaroff AL Harv. Health Lett. 39(6), 2, (2014)

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In brief: enteric-coated aspirin as an antiplatelet drug. Med. Lett. Drugs Ther. 56(1441), 36, (2014)

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[Acetylsalicylic acid and prevention of preeclampsia]. Villa PM, Kajantie E, and Laivuori H Duodecim. 130(3), 243-50, (2014)

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[Aspirin in primary and secondary prevention of colorectal carcinomas]. Schrör K and Rauch B Med. Monatsschr. Pharm. 36(11), 411-21, (2013)

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Safer heart-attack prevention for seniors with revised drug regimen. Half the normal dose of prasugrel, a lifesaving medication, is just as effective as the larger dose, and reduces risk of serious side effects. Duke. Med. Health. News. 19(11), 1-2, (2013)

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[Aspirin: once or twice a day?]. Fontana P, Casini A, Boehlen F, et al. Rev. Med. Suisse 10(412-413), 53-6, (2014)

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[Transition of acetylsalicylic acid serum concentration in a case of overdose]. Tominaga A Chudoku. Kenkyu. 26(4), 314-5, (2013)

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[Aspirin for migraine in pregnancy. This recommendation seems questionable]. Gaul C MMW Fortschr. Med. 155(19), 17, (2013)

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[It is possible to reduce drug-drug interactions. Interactions were corrected frequently by patient-specific letters to general practitioners]. Cronberg O, Nordquist C, and Quittenbaum S Lakartidningen. 110(48), 2176-7, (2013)

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The prevalence of gastroduodenal mucosal injuries in aspirin users. Thongbai T J. Med. Assoc. Thai. 96(11), 1423-7, (2013)

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[Serious organ damage and intractable clinical conditions in rheumatic and connective tissue disease--progress in pathophysiology and treatment. Topics: II. Clinical conditions special attention needed to be paid to; 2. Antiphospholipid syndrome]. Yasuda S Nippon. Naika Gakkai Zasshi. 102(10), 2621-30, (2013)

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[Cardiovascular event in elderly patients with diabetes mellitus]. Nomura K Nihon Rinsho. 71(11), 1954-9, (2013)

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Emergency Rx for major TIA. Harv. Heart Lett. 24(1), 8, (2013)

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Taking hazards from the home to the workplace. El-Amouri I, Wynd P, and Beck J Occup. Health Saf. 82(10), 56, 58-9, (2013)

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Perioperative management of antiplatelet therapy. Oprea AD and Popescu WM Br. J. Anaesth. 111 Suppl 1, i3-17, (2013)

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PA tablets: investigational compounds combining aspirin and omeprazole for cardioprotection. Bliden KP, Brener M, Gesheff MG, et al. Future Cardiol. 9(6), 785-97, (2013)

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Testing for the 'ulcer bug' makes daily aspirin safer. Harv. Mens. Health Watch 17(11), 8, (2013)

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Aspirin may lower melanoma risk. Harv. Womens. Health Watch 20(10), 8, (2013)

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[HP eradication prevents recurrent hemorrhages caused by acetylsalicylic acid]. Labenz J MMW Fortschr. Med. 155(12), 31, (2013)

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Aspirin after heart attack or stroke. Harv. Heart Lett. 23(8), 8, (2013)

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[Prevention of atherosclerosis in children--the role of statins and aspirin]. Stolarz-Skrzypek K, Bednarski A, Drozdz D, et al. Prz. Lek. 70(2), 57-64, (2013)

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Aspirin may prevent blood clots in the legs from recurring. Harv. Heart Lett. 23(6), 8, (2013)

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Prophylaxis against venous thromboembolism after arthroplasty: establishing value requires more than one perspective. Commentary on an article by John T. Schousboe, MD, PhD, and Gregory A. Brown, MD, PhD: "Cost-effectiveness of low-molecular-weight heparin compared with aspirin for prophylaxis against venous thromboembolism after total joint arthroplasty". Yates AJ J. Bone Joint Surg. Am. 95(14), e102 1-2, (2013)

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Early dual therapy for Chinese adults with TIA. BMJ 347, f4197, (2013)

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Deep venous thrombosis and pulmonary embolism. Part 2--Prevention of recurrences: warfarin or low-molecular-weight heparin for at least 3 months. Prescrire Int. 22(138), 129-33, (2013)

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[New form of a acetylsalicylic acid in the secondary prevention of ischemic stroke]. Shepankevich LA, Vostrikova EB, and Pilipenko PI Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova 113(4), 92-4, (2013)

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My father has been diagnosed with giant cell arteritis. What is this, and is it a serious? Duke. Med. Health. News. 19(5), 8, (2013)

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[Rational pharmacotherapy of patients with coronory heart disease combined with anxiety disorders]. Korzh AN, Krasnokutskiĭ SV, and Maĭboroda OF Lik. Sprava (8), 101-7, (2012)

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[Secondary prevention with clopidogrel after TIA or stroke]. Zuurbier SM, Vermeer SE, Hilkens PH, et al. Ned. Tijdschr. Geneeskd. 157(25), A5836, (2013)

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Histamine H2 receptor antagonists for decreasing gastrointestinal harms in adults using acetylsalicylic acid: systematic review and meta-analysis. Tricco AC, Alateeq A, Tashkandi M, et al. Open Med. 6(3), e109-17, (2012)

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[Why does acetylsalicylic acid have so many effects and applications?]. Pelkonen O Duodecim. 125(22), 2433-9, (2009)

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Acetylsalicylic acid for the prevention of preeclampsia and intra-uterine growth restriction in women with abnormal uterine artery Doppler: a systematic review and meta-analysis. Bujold E, Morency AM, Roberge S, et al. J. Obstet. Gynaecol. Can. 31(9), 818-26, (2009)

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[Acetylsalicylic acid in patients with diabetes mellitus: can be used for secondary but not primary prevention of cardiovascular events]. Klomp CM, ten Cate H, Stehouwer CD, et al. Ned. Tijdschr. Geneeskd. 153, A109, (2009)

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[Routine platelet aggregation inhibition not useful when using acetylsalicylic acid or clopidogrel]. Kramer MC, Nieuwland R, Sturk A, et al. Ned. Tijdschr. Geneeskd. 153(5), 190-5, (2009)

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[Attempts for aspirin monitoring with a new assay system, Ultegra Rapid Platelet Function Assay (RPFA), based on turbidimetric platelet agglutination of whole blood samples]. Satoh K and Ozaki Y Rinsho Byori. 54(6), 576-82, (2006)

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Aspirin resistance and its implications in clinical practice. Eikelboom J, Feldman M, Mehta SR, et al. MedGenMed 7(3), 76, (2005)

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Spectrophotometric determination of drugs with iodine. Karuna T, et al. J. Sci. Ind. Res. 65(10), 808, (2006)

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Aspirin and clopidogrel drug response in patients undergoing percutaneous coronary intervention: the role of dual drug resistance. Lev EI, Patel RT, Maresh KJ, et al. J. Am. Coll. Cardiol. 47(1), 27-33, (2006)

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Overestimation of platelet aspirin resistance detection by thrombelastograph platelet mapping and validation by conventional aggregometry using arachidonic acid stimulation. Tantry US, Bliden KP, and Gurbel PA J. Am. Coll. Cardiol. 46(9), 1705-9, (2005)

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Repeat head computed tomography in anticoagulated traumatic brain injury patients: still warranted. Joseph B, Sadoun M, Aziz H, et al. Am. Surg. 80(1), 43-7, (2014)

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New nitric oxide or hydrogen sulfide releasing aspirins. Loretta Lazzarato et al J. Med. Chem. 54, 5478-84, (2011)

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The Japanese toxicogenomics project: application of toxicogenomics. Takeki Uehara et al Mol. Nutr. Food. Res. 54, 218-27, (2010)

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Diazen-1-ium-1,2-diolated and nitrooxyethyl nitric oxide donor ester prodrugs of anti-inflammatory (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic acids: synthesis, cyclooxygenase inhibition, and nitric oxide release studies. Khaled R A Abdellatif et al Bioorg. Med. Chem. 16, 3302-8, (2008)

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'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors. Norbert Handler et al Bioorg. Med. Chem. 15, 6109-18, (2007)

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In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II. Esra Bayram et al Bioorg. Med. Chem. 16, 9101-5, (2008)

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Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway: a 700-patient study of aspirin resistance. Frelinger AL, Furman MI, Linden MD, et al. Circulation 113(25), 2888-96, (2006)

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Hologram QSAR model for the prediction of human oral bioavailability. Tiago L Moda et al Bioorg. Med. Chem. 15, 7738-45, (2007)

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Structural and functional basis of cyclooxygenase inhibition. Anna L Blobaum et al J. Med. Chem. 50, 1425-41, (2007)

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Discovery of a "true" aspirin prodrug. Louise M Moriarty et al J. Med. Chem. 51, 7991-9, (2008)

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Medical management after coronary stent implantation: a review. Brilakis ES, Patel VG, and Banerjee S JAMA 310(2), 189-98, (2013)

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Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. Wang Y, Wang Y, Zhao X, et al. N. Engl. J. Med. 369(1), 11-9, (2013)

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N-1 and C-3 substituted indole Schiff bases as selective COX-2 inhibitors: Synthesis and biological evaluation. Jatinder Kaur et al Bioorg. Med. Chem. Lett. 22, 2154-9, (2012)

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Synthesis of new 4-[2-(4-methyl(amino)sulfonylphenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-1,2,3,6-tetrahydropyridines: a search for novel nitric oxide donor anti-inflammatory agents. Morshed Alam Chowdhury et al Bioorg. Med. Chem. 16, 8882-8, (2008)

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

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Antitumor-active cobalt-alkyne complexes derived from acetylsalicylic acid: studies on the mode of drug action. Ingo Ott et al J. Med. Chem. 48, 622-9, (2005)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Novel antagonists of serotonin-4 receptors: synthesis and biological evaluation of pyrrolothienopyrazines. Stephane Lemaitre, et al Bioorg. Med. Chem. 17, 2607-2622, (2009)

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Evaluation of a published in silico model and construction of a novel Bayesian model for predicting phospholipidosis inducing potential. Dennis J Pelletier et al J. Chem. Inf. Model. 47, 1196-205, (2007)

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Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells. Li C, Lee PS, Sun Y, et al. J. Exp. Med. 211(1), 15-28, (2014)

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Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 1-(4-methanesulfonylphenyl)-5-aryl-1H-pyrazol-3-carboxylic acids: synthesis, nitric oxide release studies and anti-inflammatory activities. Khaled R A Abdellatif et al Bioorg. Med. Chem. 16, 6528-34, (2008)

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Rationale and design of The Intracoronary Stenting and Antithrombotic Regimen-Testing of a six-week versus a six-month clopidogrel treatment Regimen In Patients with concomitant aspirin and oraL anticoagulant therapy following drug-Eluting stenting (ISAR-TRIPLE) study. Fiedler KA, Byrne RA, Schulz S, et al. Am. Heart J. 167(4), 459-465.e1, (2014)

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Role of aspirin in cancer prevention. Thorat MA and Cuzick J Curr. Oncol. Rep. 15(6), 533-40, (2013)

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Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies. Khaled R A Abdellatif et al Bioorg. Med. Chem. 16, 9694-8, (2008)

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Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies. Khaled R A Abdellatif et al Bioorg. Med. Chem. 17, 5182-8, (2009)

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Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies. Khaled R A Abdellatif et al Bioorg. Med. Chem. Lett. 19, 3014-8, (2009)

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Aspirin use and survival after the diagnosis of breast cancer: a population-based cohort study. Fraser DM, Sullivan FM, Thompson AM, et al. Br. J. Cancer 111(3), 623-7, (2014)

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Expression of HLA class I antigen, aspirin use, and survival after a diagnosis of colon cancer. Reimers MS, Bastiaannet E, Langley RE, et al. JAMA Intern. Med. 174(5), 732-9, (2014)

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Progression of asymptomatic carotid stenosis despite optimal medical therapy. Conrad MF, Baloum V, Mukhopadhyay S, et al. J. Vasc. Surg. 58(1), 128-35.e1, (2013)

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Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs. Sarthak Jain et al J. Med. Chem. 55, 688-96, (2012)

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Novel (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic ester prodrugs possessing a diazen-1-ium-1,2-diolate moiety: design, synthesis, cyclooxygenase inhibition, and nitric oxide release studies. Khaled R A Abdellatif et al Bioorg. Med. Chem. 15, 6796-801, (2007)

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Resveratrol derivatives from the roots of Vitis thunbergii. Yu-Ling Huang et al J. Nat. Prod. 68, 217-20, (2005)

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(Nitrooxyacyloxy)methyl esters of aspirin as novel nitric oxide releasing aspirins. Loretta Lazzarato et al J. Med. Chem. 52, 5058-68, (2009)

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Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents. Suresh Khode et al Eur. J. Med. Chem. 44, 1682-8, (2009)

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Complement C3a and C4a increased in plasma of patients with aspirin-induced asthma. Lee SH, Rhim T, Choi YS, et al. Am. J. Respir. Crit. Care Med. 173(4), 370-8, (2006)

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Does acetylsalicylic acid or warfarin affect the accuracy of fecal occult blood tests? Gandhi S, Narula N, Gandhi S, et al. J. Gastroenterol. Hepatol. 28(6), 931-6, (2013)

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Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor. Hiroki Kakuta et al J. Med. Chem. 51, 2400-11, (2008)

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Thrombocytosis is associated with increased short and long term mortality after exacerbation of chronic obstructive pulmonary disease: a role for antiplatelet therapy? Harrison MT, Short P, Williamson PA, et al. Thorax 69(7), 609-15, (2014)

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Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue. Colas RA, Shinohara M, Dalli J, et al. Am. J. Physiol. Cell Physiol. 307(1), C39-54, (2014)

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Novel natural product-based cinnamates and their thio and thiono analogs as potent inhibitors of cell adhesion molecules on human endothelial cells. Sarvesh Kumar et al Eur. J. Med. Chem. 46, 5498-511, (2011)

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1-Acylthiosemicarbazides, 1,2,4-triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: synthesis, analgesic-anti-inflammatory and antimicrobial activities. Umut Salgin-Gök?en et al Bioorg. Med. Chem. 15, 5738-51, (2007)

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Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Francisco J Prado-Prado et al Bioorg. Med. Chem. 18, 2225-31, (2010)

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Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers. Morshed Alam Chowdhury et al Bioorg. Med. Chem. 16, 1948-56, (2008)

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Preparation of 5-aryl-3-alkylthio-l,2,4-triazoles and corresponding sulfones with antiinflammatory-analgesic activity. Birsen Tozkoparan et al Bioorg. Med. Chem. 15, 1808-14, (2007)

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Synthesis and biological evaluation of novel angularly fused polycyclic coumarins. Imtyaz A Khan et al Bioorg. Med. Chem. Lett. 15, 3584-7, (2005)

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A new therapeutic approach in Alzheimer disease: some novel pyrazole derivatives as dual MAO-B inhibitors and antiinflammatory analgesics. Nesrin Gökhan-Kelekçi et al Bioorg. Med. Chem. 15, 5775-86, (2007)

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Low-dose aspirin for prevention of morbidity and mortality from preeclampsia: a systematic evidence review for the U.S. Preventive Services Task Force. Henderson JT, Whitlock EP, O'Connor E, et al. Ann. Intern. Med. 160(10), 695-703, (2014)

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Synthesis and pharmacological evaluation of 1,3,4-oxadiazole bearing bis(heterocycle) derivatives as anti-inflammatory and analgesic agents. B Jayashankar et al Eur. J. Med. Chem. 44, 3898-902, (2009)

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Synthesis of novel triheterocyclic thiazoles as anti-inflammatory and analgesic agents. R G Kalkhambkar et al Eur. J. Med. Chem. 42, 1272-6, (2007)

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Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. Morshed Alam Chowdhury et al Bioorg. Med. Chem. Lett. 19, 584-8, (2009)

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Bioactive cembrane diterpenoids of Anisomeles indica. Yu-Li Chen et al J. Nat. Prod. 71, 1207-12, (2008)

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New acyclic nucleosides analogues as potential analgesic, anti-inflammatory, anti-oxidant and anti-microbial derived from pyrimido[4,5-b]quinolines. A B A el-Gazzar et al Eur. J. Med. Chem. 44, 1427-36, (2009)

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Synthesis, analgesic, anti-inflammatory, and antimicrobial activity of some novel pyrimido[4,5-b]quinolin-4-ones. Abdel-Rahman B A El-Gazzar et al Bioorg. Med. Chem. 16, 3261-73, (2008)

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Bioactive compounds from Bauhinia purpurea possessing antimalarial, antimycobacterial, antifungal, anti-inflammatory, and cytotoxic activities. Surat Boonphong et al J. Nat. Prod. 70, 795-801, (2007)

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Synthesis of substituted acridinyl pyrazoline derivatives and their evaluation for anti-inflammatory activity. Trilok Chandra et al Eur. J. Med. Chem. 45, 1772-6, (2010)

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Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors. M Abdur Rahim et al Bioorg. Med. Chem. Lett. 21, 6074-80, (2011)

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Aspirin use, 8q24 single nucleotide polymorphism rs6983267, and colorectal cancer according to CTNNB1 alterations. Nan H, Morikawa T, Suuriniemi M, et al. J. Natl. Cancer Inst. 105(24), 1852-61, (2013)

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Prediction of drug intestinal absorption by new linear and non-linear QSPR. Alan Talevi et al Eur. J. Med. Chem. 46, 218-28, (2011)

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Synthesis and spectral characterization of a new class of N-(N-methylpiperazinoacetyl)-2,6-diarylpiperidin-4-ones: antimicrobial, analgesic and antipyretic studies. G Aridoss et al Eur. J. Med. Chem. 44, 577-92, (2009)

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Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: a novel class of 5-lipoxygenase inhibitors. Morshed Alam Chowdhury et al Bioorg. Med. Chem. Lett. 18, 4195-8, (2008)

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Synthesis and analgesic and anti-inflammatory activities 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(p-substituted/nonsubstituted benzal)hydrazone derivatives. Mehtap Gökçe et al Eur. J. Med. Chem. 44, 3760-4, (2009)

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Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. Morshed A Chowdhury et al Bioorg. Med. Chem. Lett. 19, 6855-61, (2009)

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Synthesis, antiplatelet and in silico evaluations of novel N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides. Alessandro K Jordão et al Bioorg. Med. Chem. 17, 3713-9, (2009)

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2-Amino-5-thiazolyl motif: a novel scaffold for designing anti-inflammatory agents of diverse structures. P X Franklin et al Eur. J. Med. Chem. 43, 129-34, (2008)

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Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies. Khaled R A Abdellatif et al Bioorg. Med. Chem. Lett. 20, 4544-9, (2010)

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Synthesis and pharmacological evaluation of novel 5-substituted-1-(phenylsulfonyl)-2-methylbenzimidazole derivatives as anti-inflammatory and analgesic agents. Monika Gaba et al Eur. J. Med. Chem. 45, 2245-9, (2010)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Preconception low-dose aspirin and pregnancy outcomes: results from the EAGeR randomised trial. Schisterman EF, Silver RM, Lesher LL, et al. Lancet 384(9937), 29-36, (2014)

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Lanostane triterpenoids and triterpene glycosides from the fruit body of Fomitopsis pinicola and their inhibitory activity against COX-1 and COX-2. Kazuko Yoshikawa et al J. Nat. Prod. 68, 69-73, (2005)

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Analgesic, anti-pyretic and DNA cleavage studies of novel pyrimidine derivatives of coumarin moiety. Rangappa S Keri et al Eur. J. Med. Chem. 45, 2597-605, (2010)

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Aspirin activation of eosinophils and mast cells: implications in the pathogenesis of aspirin-exacerbated respiratory disease. Steinke JW, Negri J, Liu L, et al. J. Immunol. 193(1), 41-7, (2014)

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Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. Gregory Kaler et al J. Biol. Chem. 282, 23841-53, (2007)

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Synthesis and anti-platelet activity of novel arylsulfonate--acylhydrazone derivatives, designed as antithrombotic candidates. Lídia M Lima et al Eur. J. Med. Chem. 43, 348-56, (2008)

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Amino acid based enantiomerically pure 3-substituted benzofused heterocycles: A new class of antithrombotic agents. Jitendra Kumar Mishra et al Bioorg. Med. Chem. Lett. 20, 244-7, (2010)

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3-Formylchromones: potential antiinflammatory agents. Khalid M Khan et al Eur. J. Med. Chem. 45, 4058-64, (2010)

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Selenium containing heterocycles: synthesis, anti-inflammatory, analgesic and anti-microbial activities of some new 4-cyanopyridazine-3(2H)selenone derivatives. Sh H Abdel-Hafez et al Eur. J. Med. Chem. 43, 1971-7, (2008)

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A class of oral N-[(1S,3S)-1-methyl-1,2,3,4-tetrahydro-?-carboline-3-carbonyl]- N'-(amino-acid-acyl)hydrazine: discovery, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis. Kun Yao et al Eur. J. Med. Chem. 46, 3237-49, (2011)

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Synthesis of 3,6-disubstituted 7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines as novel analgesic/anti-inflammatory compounds. S Peri Aytaç et al Eur. J. Med. Chem. 44, 4528-38, (2009)

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Alkaloids from Daphniphyllum oldhami. Shu-Zhen Mu et al J. Nat. Prod. 71, 564-9, (2008)

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Aspirin at low-intermediate concentrations protects retinal vessels in experimental diabetic retinopathy through non-platelet-mediated effects. Sun W, Gerhardinger C, Dagher Z, et al. Diabetes 54(12), 3418-26, (2005)

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Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors. Chen-Ming Tan et al Bioorg. Med. Chem. 19, 6316-28, (2011)

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Design and synthesis of 3-pyrazolyl-thiophene, thieno[2,3-d]pyrimidines as new bioactive and pharmacological activities. H N Hafez et al Bioorg. Med. Chem. Lett. 18, 5222-7, (2008)

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Aspirin induces platelet receptor shedding via ADAM17 (TACE). Aktas B, Pozgajova M, Bergmeier W, et al. J. Biol. Chem. 280(48), 39716-22, (2005)

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A class of novel N-(3S-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-L-amino acid derivatives: their synthesis, anti-thrombotic activity evaluation, and 3D QSAR analysis. Shenling Cheng et al Eur. J. Med. Chem. 44, 4904-19, (2009)

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Chamazulene carboxylic acid and matricin: a natural profen and its natural prodrug, identified through similarity to synthetic drug substances. Mai Ramadan et al J. Nat. Prod. 69, 1041-5, (2006)

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A class of 3S-2-aminoacyltetrahydro-beta-carboline-3-carboxylic acids: their facile synthesis, inhibition for platelet activation, and high in vivo anti-thrombotic potency. Jiawang Liu et al J. Med. Chem. 53, 3106-16, (2010)

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Cost-effectiveness of low-molecular-weight heparin compared with aspirin for prophylaxis against venous thromboembolism after total joint arthroplasty. Schousboe JT and Brown GA J. Bone Joint Surg. Am. 95(14), 1256-64, (2013)

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Association between aspirin use and age-related macular degeneration: a meta-analysis. Ye J, Xu YF, He JJ, et al. Invest. Ophthalmol. Vis. Sci. 55(4), 2687-96, (2014)

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Determination of non-steroidal anti-inflammatory drugs in pharmaceuticals and human serum by dual-mode gradient HPLC and fluorescence detection. Ibrahim H, Boyer A, Bouajila J, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 857(1), 59-66, (2007)

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Assessment of antiplatelet activity of 2-aminopyrimidines. Rajani Giridhar et al Eur. J. Med. Chem. 50, 428-32, (2012)

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Hemiterpene glucosides with anti-platelet aggregation activities from Ilex pubescens. Zhi-Hong Jiang et al J. Nat. Prod. 68, 397-9, (2005)

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Synthesis and biological evaluation of nitrogen-containing chalcones as possible anti-inflammatory and antioxidant agents. Babasaheb P Bandgar et al Bioorg. Med. Chem. Lett. 20, 730-3, (2010)

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Searching for new NO-donor aspirin-like molecules: Furoxanylacyl derivatives of salicylic acid and related furazans. Loretta Lazzarato et al Bioorg. Med. Chem. 19, 5852-60, (2011)

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Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke. Yewei Sun et al Bioorg. Med. Chem. 16, 8868-74, (2008)

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Synthetic derivatives of the alpha- and beta-amyrin triterpenes and their antinociceptive properties. Cristian Soldi et al Bioorg. Med. Chem. 16, 3377-86, (2008)

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Biological efficacy of low against medium dose aspirin regimen after coronary surgery: analysis of platelet function. Cornelissen J, Kirtland S, Lim E, et al. Thromb. Haemost. 95(3), 476-82, (2006)

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2-Substituted (S)-2-(3,3-dimethyl-1-oxo-10,10a-dihydroimidazo[1,5-b]isoquinolin-2(1H,3H,5H)-yl)acetic acids: Conformational prediction, synthesis, anti-thrombotic and vasodilative evaluation. Hong Wang et al Bioorg. Med. Chem. 19, 871-82, (2011)

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Unmet needs in the treatment of autoimmunity: from aspirin to stem cells. Chang C Autoimmun. Rev. 13(4-5), 331-46, (2014)

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Relation between atherosclerosis risk factors and aspirin resistance in a primary prevention population. Faraday N, Becker DM, Yanek LR, et al. Am. J. Cardiol. 98(6), 774-9, (2006)

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Differing administration time-dependent effects of aspirin on blood pressure in dipper and non-dipper hypertensives. Hermida RC, Ayala DE, Calvo C, et al. Hypertension 46(4), 1060-8, (2005)

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Antinociceptive properties of caffeic acid derivatives in mice. Fátima de Campos Buzzi et al Eur. J. Med. Chem. 44, 4596-602, (2009)

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Synthesis of novel 3-carboxamide-benzocoumarin derivatives as orally active antithrombotic agents. Koneni V Sashidhara et al Bioorg. Med. Chem. Lett. 21, 7034-40, (2011)

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Synthesis and in vitro antiplatelet activity of new 4-(1-piperazinyl)coumarin derivatives. Human platelet phosphodiesterase 3 inhibitory properties of the two most effective compounds described and molecular modeling study on their interactions with phosphodiesterase 3A catalytic site. Giorgio Roma et al J. Med. Chem. 50, 2886-95, (2007)

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Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Lei Du-Cuny et al Bioorg. Med. Chem. 17, 6983-92, (2009)

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Substrate specificity of acetoxy derivatives of coumarins and quinolones towards Calreticulin mediated transacetylation: Investigations on antiplatelet function. Abha Kathuria et al Bioorg. Med. Chem. 20, 1624-38, (2012)

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Combining antiplatelet and antithrombotic therapy (triple therapy): what are the risks and benefits? Asencio LA, Huang JJ, and Alpert JS Am. J. Med. 127(7), 579-85, (2014)

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Design and synthesis of novel deoxybenzoin derivatives as FabH inhibitors and anti-inflammatory agents. Huan-Qiu Li et al Bioorg. Med. Chem. Lett. 20, 2025-8, (2010)

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Synthesis of 4-substituted pyrido[2,3-d]pyrimidin-4(1H)-one as analgesic and anti-inflammatory agents. Abdel-Rahman B A El-Gazzar et al Bioorg. Med. Chem. Lett. 19, 3392-7, (2009)

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Synthesis of amidine and amide derivatives and their evaluation for anti-inflammatory and analgesic activities. S. M. Sondhi, et al., Eur. J. Med. Chem. 44, 1010-1015, (2009)

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The evaluation of 2,8-disubstituted benzoxazinone derivatives as anti-inflammatory and anti-platelet aggregation agents. Pei-Wen Hsieh et al Bioorg. Med. Chem. Lett. 15, 2786-9, (2005)

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Effects of ?-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro. Liuqiang Zhang et al Bioorg. Med. Chem. 19, 4882-6, (2011)

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Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of anticancer agents. Stanislav Gobec et al Bioorg. Med. Chem. Lett. 15, 5170-5, (2005)

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Characterization of 4-methyl-2-oxo-1,2-dihydroquinolin-6-yl acetate as an effective antiplatelet agent. Nivedita Priya et al Bioorg. Med. Chem. 18, 4085-94, (2010)

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2,3-Diamino acid modifying 3S-tetrahydroisoquinoline-3-carboxylic acids: leading to a class of novel agents with highly unfolded conformation, selective in vitro anti-platelet aggregation and potent in vivo anti-thrombotic activity. Xiaoyi Zhang et al Bioorg. Med. Chem. 18, 1536-54, (2010)

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Aspirin augments the expression of Adenomatous Polyposis Coli protein by suppression of IKKβ. Ashida N, Kishihata M, Tien DN, et al. Biochem. Biophys. Res. Commun. 446(2), 460-4, (2014)

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Gastroduodenal toxicity of low-dose acetylsalicylic acid: a comparison with non-steroidal anti-inflammatory drugs. Yeomans ND, Hawkey CJ, Brailsford W, et al. Curr. Med. Res. Opin. 25(11), 2785-93, (2009)

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Synthesis and antinociceptive activity of pyrazolyl isoxazolines and pyrazolyl isoxazoles. K Karthikeyan et al Bioorg. Med. Chem. Lett. 19, 3370-3, (2009)

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Enantioselective synthesis of (R)-(+)- and (S)-(-)-higenamine and their analogues with effects on platelet aggregation and experimental animal model of disseminated intravascular coagulation. Mi Kyung Pyo et al Bioorg. Med. Chem. Lett. 18, 4110-4, (2008)

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Synthesis, resolution, and antiplatelet activity of 3-substituted 1(3H)-isobenzofuranone. Hua Yang et al Bioorg. Med. Chem. Lett. 17, 5210-3, (2007)

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Reduced blood platelet sensitivity to aspirin in coronary artery disease: are dyslipidaemia and inflammatory states possible factors predisposing to sub-optimal platelet response to aspirin? Markuszewski L, Rosiak M, Golanski J, et al. Basic Clin Pharmacol Toxicol. 98(5), 503-9, (2006)

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NO-NSAIDs: Gastric-sparing nitric oxide-releasable prodrugs of non-steroidal anti-inflammatory drugs. Kumar V S Nemmani et al Bioorg. Med. Chem. Lett. 19, 5297-301, (2009)

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Synthesis, biological and medicinal significance of S-glycosido-thieno[2,3-d]-pyrimidines as new anti-inflammatory and analgesic agents. Hend N Hafez et al Eur. J. Med. Chem. 45, 1485-93, (2010)

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Marine sponge Hymeniacidon sp. amphilectane metabolites potently inhibit rat brain microglia thromboxane B(2) generation. Alejandro M S Mayer et al Bioorg. Med. Chem. 20, 279-82, (2012)

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Synthesis, antileukemic and antiplatelet activities of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines. R Ramajayam et al Eur. J. Med. Chem. 43, 2004-10, (2008)

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A new class of anti-thrombosis hexahydropyrazino-[1',2':1,6]pyrido-[3,4-b]-indole-1,4-dions: design, synthesis, logK determination, and QSAR analysis. Jiawang Liu et al Bioorg. Med. Chem. 15, 5672-93, (2007)

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COX, LOX and platelet aggregation inhibitory properties of Lauraceae neolignans. Ericsson David Coy et al Bioorg. Med. Chem. Lett. 19, 6922-5, (2009)

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Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach. Perumal Yogeeswari et al J. Med. Chem. 50, 2459-67, (2007)

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The hazards of discontinuing acetylsalicylic acid therapy in those at risk of coronary artery disease. Lotrionte M and Biondi-Zoccai GG Curr. Opin. Cardiol. 23(5), 487-93, (2008)

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A class of novel N-(1-methyl-?-carboline-3-carbonyl)-N'-(aminoacid-acyl)-hydrazines: aromatization leaded design, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis. Chunyu Li et al Eur. J. Med. Chem. 46, 5598-608, (2011)

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Ipomotaosides A-D, resin glycosides from the aerial parts of Ipomoea batatas and their inhibitory activity against COX-1 and COX-2. Kazuko Yoshikawa et al J. Nat. Prod. 73, 1763-6, (2010)

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Pharmacogenomics of acetylsalicylic acid and other nonsteroidal anti-inflammatory agents: clinical implications. Yiannakopoulou E Eur. J. Clin. Pharmacol. 69(7), 1369-73, (2013)

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(3S)-N-(L-Aminoacyl)-1,2,3,4-tetrahydroisoquinolines, a class of novel antithrombotic agents: synthesis, bioassay, 3D QSAR, and ADME analysis. Meiqing Zheng et al Bioorg. Med. Chem. 16, 9574-87, (2008)

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Design, synthesis and evaluation of tetrahydropyran based COX-1/-2 inhibitors. Palwinder Singh et al Eur. J. Med. Chem. 44, 1278-87, (2009)

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4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase. Michel Boulouard et al Bioorg. Med. Chem. Lett. 17, 3177-80, (2007)

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Oleic Acid, deglycosylated vitamin D-binding protein, nitric oxide: a molecular triad made lethal to cancer. Ruggiero M, Ward E, Smith R, et al. Anticancer Res. 34(7), 3569-78, (2014)

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Synthesis and crystallographic analysis of benzophenone derivatives--the potential anti-inflammatory agents. T D Venu et al Bioorg. Med. Chem. 15, 3505-14, (2007)

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Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors. Xiaoxia Zheng et al Bioorg. Med. Chem. 15, 1014-21, (2007)

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Synthesis and biological evaluation of amide derivatives of (5,6-dimethoxy-2,3-dihydro-1H-inden-1-yl)acetic acid as anti-inflammatory agents with reduced gastrointestinal ulcerogenecity. Meenakshi Sharma et al Eur. J. Med. Chem. 43, 2092-102, (2008)

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Derivatives of pyrrolo[3,4-d]pyridazinone, a new class of analgesic agents. Wiesław Malinka et al Eur. J. Med. Chem. 46, 4992-9, (2011)

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Synthesis and evaluation of nitric oxide-releasing derivatives of 3-n-butylphthalide as anti-platelet agents. Yang Li et al Bioorg. Med. Chem. Lett. 21, 4210-4, (2011)

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Neural computational prediction of oral drug absorption based on CODES 2D descriptors. A Guerra et al Eur. J. Med. Chem. 45, 930-40, (2010)

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Toward the development of chemoprevention agents. Part II: Chemo-enzymatic synthesis and anti-inflammatory activities of a new class of 5-amino-2-substitutedphenyl-1,3-dioxacycloalkanes. Keli Gu et al Bioorg. Med. Chem. 15, 6273-90, (2007)

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QSAR-based permeability model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 19, 2615-24, (2011)

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Synthesis and biological evaluation of sulfonylurea and thiourea derivatives substituted with benzenesulfonamide groups as potential hypoglycemic agents. Hui-Bin Zhang et al Bioorg. Med. Chem. Lett. 19, 1740-4, (2009)

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Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines. T D Venu et al Bioorg. Med. Chem. Lett. 18, 4409-12, (2008)

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Aspirin antagonism in isoniazid treatment of tuberculosis in mice. Sean T Byrne et al Antimicrob. Agents Chemother. 51, 794-5, (2007)

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Synthesis of 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as platelet aggregation inhibitors. Xiao Tian et al Bioorg. Med. Chem. Lett. 22, 204-6, (2012)

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Enhancement of matrix metalloproteinase 2 and 9 inhibitory action of minocycline by aspirin: an approach to attenuate outcome of acute myocardial infarction in diabetes. Bhatt LK and Veeranjaneyulu A Arch. Med. Res. 45(3), 203-9, (2014)

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Incidence of intracranial hemorrhage and outcomes after ground-level falls in geriatric trauma patients taking preinjury anticoagulants and antiplatelet agents. Reddy S, Sharma R, Grotts J, et al. Am. Surg. 80(10), 975-8, (2014)

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Aspirin increases the risk of venous thromboembolism in surgical patients. Barmparas G, Jain M, Mehrzadi D, et al. Am. Surg. 80(10), 920-5, (2014)

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[Clinical significance of and treatment options for increased lipoprotein(a)]. Zsíros N, Paragh G, and Harangi M Orv. Hetil. 155(16), 607-14, (2014)

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Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)

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Polycyclic cage structures as carrier molecules for neuroprotective non-steroidal anti-inflammatory drugs. Louis H A Prins et al Eur. J. Med. Chem. 44, 2577-82, (2009)

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A class of novel Schiff's bases: Synthesis, therapeutic action for chronic pain, anti-inflammation and 3D QSAR analysis. Yinjian Zhou et al Bioorg. Med. Chem. 18, 2165-72, (2010)

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Structure-activity relationship of salicylic acid derivatives on inhibition of TNF-? dependent NF?B activity: Implication on anti-inflammatory effect of N-(5-chlorosalicyloyl)phenethylamine against experimental colitis. Jihye Kim et al Eur. J. Med. Chem. 48, 36-44, (2012)

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Synthesis of new 1-phenyl-3-{4-[(2E)-3-phenylprop-2-enoyl]phenyl}-thiourea and urea derivatives with anti-nociceptive activity. Lorena dos Santos et al Bioorg. Med. Chem. 16, 8526-34, (2008)

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Synthesis and biological evaluation of N-antipyrine-4-substituted amino-3-chloromaleimide derivatives. Fernanda Mahle et al Eur. J. Med. Chem. 45, 4761-8, (2010)

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Aspirin desensitization: useful treatment for chronic rhinosinusitis with nasal polyps (CRSwNP) in aspirin-exacerbated respiratory disease (AERD)? Klimek L, Dollner R, Pfaar O, et al. Curr. Allergy Asthma Rep. 14(6), 441, (2014)

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Inhibitory effect of macabarterin, a polyoxygenated ellagitannin from Macaranga barteri, on human neutrophil respiratory burst activity. Rostand Manfouo Ngoumfo et al J. Nat. Prod. 71, 1906-10, (2008)

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Aspirin use and melanoma risk: a review of the literature. Famenini S and Young LC J. Am. Acad. Dermatol. 70(1), 187-91, (2014)

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The evaluation and structure-activity relationships of 2-benzoylaminobenzoic esters and their analogues as anti-inflammatory and anti-platelet aggregation agents. Pei-Wen Hsieh et al Bioorg. Med. Chem. Lett. 17, 1812-7, (2007)

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Aspirin but not meloxicam attenuates early atherosclerosis in apolipoprotein E knockout mice. Kraus S, Naumov I, Shapira S, et al. Isr. Med. Assoc. J. 16(4), 233-8, (2014)

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Synthesis, nano-scale assembly, and in vivo anti-thrombotic activity of novel short peptides containing L-Arg and L-Asp or L-Glu. Yu Chen et al Bioorg. Med. Chem. 16, 5914-25, (2008)

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Synthesis and anti-platelet evaluation of 2-benzoylaminobenzoate analogs. Pei-Wen Hsieh et al Bioorg. Med. Chem. 16, 5803-14, (2008)

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10H-Phenothiazines: a new class of enzyme inhibitors for inflammatory diseases. Y S Sadanandam et al Eur. J. Med. Chem. 44, 197-202, (2009)

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Ixorapeptide I and ixorapeptide II, bioactive peptides isolated from Ixora coccinea. Chia-Lin Lee et al Bioorg. Med. Chem. Lett. 20, 7354-7, (2010)

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Association between silent embolic cerebral infarction and continuous increase of P2Y12 reaction units after neurovascular stenting. Kim BJ, Kwon JY, Jung JM, et al. J. Neurosurg. 121(4), 891-8, (2014)

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Quiquelignan A-H, eight new lignoids from the rattan palm Calamus quiquesetinervius and their antiradical, anti-inflammatory and antiplatelet aggregation activities. Chao-Lin Chang et al Bioorg. Med. Chem. 18, 518-25, (2010)

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NSAIDs revisited: putative molecular basis of their interactions with peroxisome proliferator-activated gamma receptor (PPARgamma). Nelilma C Romeiro et al Eur. J. Med. Chem. 43, 1918-25, (2008)

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Screening for deep vein thrombosis after periacetabular osteotomy in adult patients: is it necessary? Polkowski GG, Duncan ST, Bloemke AD, et al. Clin. Orthop. Relat. Res. 472(8), 2500-5, (2014)

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A case-cohort study of postoperative myocardial infarction: impact of anemia and cardioprotective medications. Henke PK, Zamora-Berridi G, Englesbe MJ, et al. Surgery 156(4), 1018-26, 1029, (2014)

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Novel ?-carboline-tripeptide conjugates attenuate mesenteric ischemia/reperfusion injury in the rat. Wei Bi et al Eur. J. Med. Chem. 46, 2441-52, (2011)

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Toward the development of chemoprevention agents (III): synthesis and anti-inflammatory activities of a new class of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes. Lanrong Bi et al Bioorg. Med. Chem. 16, 1764-74, (2008)

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Acetylsalicylic acid + extended-release dipyridamole combination therapy for secondary stroke prevention. Chaturvedi S Clin. Ther. 30(7), 1196-205, (2008)

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The association of four common polymorphisms from four candidate genes (COX-1, COX-2, ITGA2B, ITGA2) with aspirin insensitivity: a meta-analysis. Weng Z, Li X, Li Y, et al. PLoS ONE 8(11), e78093, (2013)

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Immune thrombocytopenic purpura and myocardial infarction: a dilemma of management. Zaid G, Dawod S, and Rosenschein U Isr. Med. Assoc. J. 15(12), 775-6, (2013)

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Outcome of overt stroke in sickle cell anaemia, a single institution's experience. Majumdar S, Miller M, Khan M, et al. Br. J. Haematol. 165(5), 707-13, (2014)

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Acetylsalicylic acid/esomeprazole fixed-dose combination. Burness CB and Scott LJ Drugs Aging 29(3), 233-42, (2012)

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Protective actions of aspirin-triggered (17R) resolvin D1 and its analogue, 17R-hydroxy-19-para-fluorophenoxy-resolvin D1 methyl ester, in C5a-dependent IgG immune complex-induced inflammation and lung injury. Tang H, Liu Y, Yan C, et al. J. Immunol. 193(7), 3769-78, (2014)

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Non-steroidal anti-inflammatory drugs and cancer risk in women: results from the Women's Health Initiative. Brasky TM, Liu J, White E, et al. Int. J. Cancer 135(8), 1869-83, (2014)

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Thromboprophylaxis with dabigatran leads to an increased incidence of wound leakage and an increased length of stay after total joint replacement. Bloch BV, Patel V, and Best AJ Bone Joint J. 96-B(1), 122-6, (2014)

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A class of novel nitronyl nitroxide labeling basic and acidic amino acids: synthesis, application for preparing ESR optionally labeling peptides, and bioactivity investigations. Jianwei Zhang et al Bioorg. Med. Chem. 16, 4019-28, (2008)

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Toward the development of chemoprevention agents. Part 1: Design, synthesis, and anti-inflammatory activities of a new class of 2,5-disubstituted-dioxacycloalkanes. Keli Gu et al Bioorg. Med. Chem. 15, 4775-99, (2007)

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Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation. Chiara Brullo et al Bioorg. Med. Chem. Lett. 22, 1125-9, (2012)

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A practical deuterium-free NMR method for the rapid determination of 1-octanol/water partition coefficients of pharmaceutical agents. Huaping Mo et al Bioorg. Med. Chem. Lett. 20, 6712-5, (2010)

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Triple versus dual antiplatelet therapy in acute coronary syndromes: adding cilostazol to aspirin and clopidogrel? Niazi AK, Dinicolantonio JJ, Lavie CJ, et al. Cardiology 126(4), 233-43, (2013)

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Synthesis and anti-inflammatory activity of 2-aryloxy methyl oxazolines. Shaukath Ara Khanum et al Bioorg. Med. Chem. Lett. 18, 4597-601, (2008)

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Impact of dual antiplatelet therapy on outcomes among aspirin-resistant patients following coronary artery bypass grafting. Gasparovic H, Petricevic M, Kopjar T, et al. Am. J. Cardiol. 113(10), 1660-7, (2014)

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Aromatic amide derivatives of 5,6-dimethoxy-2,3-dihydro-1H-inden(-1-yl)acetic acid as anti-inflammatory agents free of ulcerogenic liability. Meenakshi Sharma et al Bioorg. Med. Chem. Lett. 17, 6790-6, (2007)

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[Effect of AChE and BuChE inhibition by rivastigmin in a group of old-old elderly patients with cerebrovascular impairment (SIVD type)]. Servello A, Andreozzi P, Bechini F, et al. Minerva Med. 105(2), 167-74, (2014)

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Aspirin may prevent cholangiocarcinoma: a case-control study from the United kingdom. Burr NE, Talboys RJ, Savva S, et al. Dig. Dis. Sci. 59(7), 1567-72, (2014)

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Aspirin and proton pump inhibitor combination therapy for prevention of cardiovascular disease and Barrett's esophagus. Peura DA and Wilcox CM Postgrad. Med. 126(1), 87-96, (2014)

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Aspirin for cardioprotection and strategies to improve patient adherence. Duffy D, Kelly E, Trang A, et al. Postgrad. Med. 126(1), 18-28, (2014)

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Aspirin allergy in patients with myocardial infarction: the allergist's role. McMullan KL Ann. Allergy Asthma Immunol. 112(2), 90-3, (2014)

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Approach to desensitization in aspirin-exacerbated respiratory disease. Scott DR and White AA Ann. Allergy Asthma Immunol. 112(1), 13-7, (2014)

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Aspirin reduces serum anti-melanocyte antibodies and soluble interleukin-2 receptors in vitiligo patients. Zailaie MZ Saudi Med. J. 26(7), 1085-91, (2005)

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Involvement of glutamate-cystine/glutamate transporter system in aspirin-induced acute gastric mucosa injury. Du J, Li XH, Zhang W, et al. Biochem. Biophys. Res. Commun. 450(1), 135-41, (2014)

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Duration of effects of aspirin on platelet function in healthy volunteers: an analysis using the PFA-100. Konrad CJ, Schuepfer GK, Gerber H, et al. J. Clin. Anesth. 18(1), 12-7, (2006)

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Impacts of COX-1 gene polymorphisms on vascular outcomes in patients with ischemic stroke and treated with aspirin. Cao L, Zhang Z, Sun W, et al. Gene 546(2), 172-6, (2014)

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[Differentiated antiplatelet therapy for acute coronary syndromes]. Schäfer A, Arntz HR, Boudriot E, et al. Dtsch. Med. Wochenschr. 139(4), 152-8, (2014)

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Inhibitory effects of acetylsalicylic acid on exocrine pancreatic carcinogenesis. Yıldız H, Oztas H, Yıldız D, et al. Biotech. Histochem. 88(3-4), 132-7, (2013)

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Aspirin allergy desensitization in cerebrovascular disease. A report of two cases, literature review and management guide for the neurointerventionalist. Zuckerman SL, Seder DB, Tsujiura C, et al. Interv. Neuroradiol. 20(1), 5-11, (2014)

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[Aspirin resistance candidate genes and their association with the risk of fatal cardiovascular events]. Grinshtein YI, Kosinova AA, and Grinshtein IY Ter. Arkh. 85(5), 95-100, (2013)

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[Thienopyridines in the treatment and prevention of cardiovascular diseases. III. therapeutic application of clopidogrel as monotherapy (without acetylsalicylic acid)]. Preobrazhenskiĭ DV, Sidorenko BA, Batyraliev TA, et al. Kardiologiia 49(12), 63-7, (2009)

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[Acetylsalicylic acid in patients with planned (elective) interventions on the coronary arteries. Risks and benefits]. Altarev SS and Barbarash OL Kardiologiia 52(4), 60-7, (2012)

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[Cyclooxygenase inhibitors and antiplatelet effect of acetylsalicylic acid. selective approach to nonsteroidal anti-inflammatory drugs in cardiological practice]. Lomakin NV and Gruzdev AK Kardiologiia 51(7), 47-52, (2011)

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[Efficacy and safety of various doses of acetylsalicylic Acid in prevention of complications of atherothrombosis]. Komarov AL Kardiologiia 50(10), 56-61, (2010)

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[Thienopyridines in the treatment and prevention of cardiovascular diseases. Part V. Combination of clopidogrel and acetylsalicylic acid in the treatment of stable patients with atherothrombotic cardiovascular diseases]. Preobrazhenskiĭ DV, Sidorenko BA, Fettser DV, et al. Kardiologiia 50(5), 73-6, (2010)

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[Thienopyridines in the treatment and prevention of cardiovascular diseases. Part IV. therapeutic application of clopidogrel in combination with acetylsalicylic acid in acute coronary syndromes and percutaneous coronary interventions]. Preobrazhenskiĭ DV, Sidorenko BA, Batyraliev TA, et al. Kardiologiia 49(12), 68-74, (2009)

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Researchers ponder aspirin's potential in preventing cancer. Rubin R JAMA 312(15), 1501-2, (2014)

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NSAID-associated gastrointestinal bleeding: assessing the role of concomitant medications. Laine L Gastroenterology 147(4), 730-3, (2014)

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A curious case of abdominal pain relieved by aspirin. Dhaliwal HS, Makkar DS, and Gowda KK Gastroenterology 147(4), 745-8, (2014)

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Reply to the letter to the editor: symptomatic pulmonary embolus after joint arthroplasty: stratification of risk factors. Parvizi J, Huang R, Raphael IJ, et al. Clin. Orthop. Relat. Res. 472(8), 2554, (2014)

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Letter to the editor: symptomatic pulmonary embolus after joint arthroplasty: stratification of risk factors. Eroglu M, Senturk I, and Gunay E Clin. Orthop. Relat. Res. 472(8), 2552-3, (2014)

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Antifibrinolytics, aspirin and cardiac surgery: evidence, guidelines and implications for current research. Myles PS Anaesth. Intensive Care 42(3), 293-7, (2014)

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Myocardial infarction risks remain for patients undergoing noncardiac elective surgery. Mitka M JAMA 311(19), 1955-6, (2014)

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FDA questions use of aspirin for primary prevention of stroke and heart attack. McCarthy M BMJ 348, g3168, (2014)

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The devastating power of platelets in COPD exacerbations: can aspirin save lives in COPD? Sin DD Thorax 69(7), 603-4, (2014)

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The landscape of thromboprophylaxis utilization in critically ill children: sparse and variable. Gist KM and Chima RS Crit. Care Med. 42(5), 1317-8, (2014)

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Dual antiplatelet therapy after stent implantation. Greene SJ, Alkhawam L, and Vaduganathan M JAMA 311(14), 1446, (2014)

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Improving livebirth rates: a role for preconception aspirin? Chescheir NC and Goodnight W Lancet 384(9937), 5-6, (2014)

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Aspirin as adjuvant therapy for stage III colon cancer: standard of care? Neugut AI JAMA Intern. Med. 174(5), 739-41, (2014)

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The yin and yang of perioperative medicine. Vaishnava P and Eagle KA N. Engl. J. Med. 370(16), 1554-5, (2014)

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Smoking status and the effects of antiplatelet drugs. Hirschl MM BMJ 347, f5909, (2013)

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LOAD: a pilot study of the safety of loading of aspirin & clopidogrel in acute ischaemic stroke and transient ischaemic attack. Is the loading dose of aspirin and clopidogrel a good alternative for patients with acute ischaemic stroke and TIA? How this will impact our clinical practice? Nomani F and Kamal AK J. Pak. Med. Assoc. 63(10), 1316, (2013)

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[From apixaban to aspirin in the prevention of recurrent venous thromboembolism]. Diez-Ewald M Invest. Clin. 54(3), 231-3, (2013)

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Genome-wide association studies meet chemoprevention. Thompson PA J. Natl. Cancer Inst. 105(24), 1847-8, (2013)

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Polypill for cardiovascular disease prevention. Dalton AR JAMA 310(7), 749, (2013)

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Long-term effect of carotid surgery in asymptomatic stenosis. Wadiwala MF and Kamal AK J. Pak. Med. Assoc. 62(7), 739-40, (2012)

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Sarpogrelate- another new antiplatelet agent? Shaikh Q and Kamal AK J. Pak. Med. Assoc. 62(11), 1253, (2012)

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Antiplatelet therapy and anticoagulants - authors' reply. Dewilde WJ, Verheugt FW, and Ten Berg JM Lancet 382(9886), 25, (2013)

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Antiplatelet therapy and anticoagulants. Hudzik B, Lekston A, and Polonski L Lancet 382(9886), 24, (2013)

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Hidden implications: potential antiplatelet effects of adjuvant anaesthetic agents. Callender RA, Mukalel J, Altamirano AV, et al. Anaesth. Intensive Care 41(4), 550-1, (2013)

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Differential effects of aspirin before and after diagnosis of colorectal cancer. Pasche B JAMA 309(24), 2598-9, (2013)

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Merck 14,851

Beil. 10,IV,138

Aldrich MSDS 1, 26:B / Corp MSDS 1 (1), 48:C / FT-IR 1 (2), 315:D / FT-IR 2 (2), 2887:B / FT-NMR 1 (2), 1293:B / IR-Spectra (2), 909:F / IR-Spectra (3), 1040:A / NMR-Reference 2 (2), 303:D / RegBook 1 (2), 1929:K / Sax 6, 88 / Sigma FT-IR 1 (1), 610:B / Structure Index 1, 310:C:4

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