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A5513 Sigma

N-Acetylprocainamide hydrochloride

≥99% (HPLC), powder

Synonym: N-Acetylnovocainamide hydrochloride, Acecainide hydrochloride, NAPA

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Properties

Related Categories A-AM, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   IYEWBJUCJHKLHD-UHFFFAOYSA-N
assay   ≥99% (HPLC)
form   powder
mp   184-186 °C(lit.)
solubility   H2O: soluble50 mg/mL
storage temp.   −20°C

Description

Packaging

1, 5 g in poly bottle

Application

N-Acetylprocainamide hydrochloride is a class III antiarrhythmic compound. N-Acetylprocainamide hydrochloride has been used in a study to determine the disposition of procainamide and N-acetylprocainamide in protein-calorie malnutrition. N-Acetylprocainamide hydrochloride has also been used to study pharmacokinetics of procainamide and N-acetylprocainamide in rats.

Biochem/physiol Actions

Class III antiarrhythmic. Increases the duration of the action potential by decreasing the delayed outward potassium current, slightly decreasing the calcium current, and slightly depressing the inward rectifier potassium current. This is the active metabolite of procainamide that does not induce systemic lupus erythematosus.

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RIDADR 
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Peer-Reviewed Papers
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