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A5585 Sigma

5-(N-Methyl-N-isobutyl)­amiloride

≥98% (TLC), powder

Synonym: MIA

  • CAS Number 96861-65-3

  • Empirical Formula (Hill Notation) C11H18ClN7O

  • Molecular Weight 299.76

  •  MDL number MFCD00078567

  •  PubChem Substance ID 24278228

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Properties

Related Categories A to C, Adenosinetriphosphatase (Na/K), Amiloride and Derivatives, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
InChI Key   RVIUMPLAOXSSGN-UHFFFAOYSA-N
assay   ≥98% (TLC)
form   powder
storage temp.   2-8°C
Gene Information   human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768)

Description

Biochem/physiol Actions

Potent blocker of the Na+/H+ antiport. Possible antitumor agent.

Packaging

25 mg in poly bottle

Application

5-(N-Methyl-N-isobutyl)­amiloride is a potent blocker of the Na2/H+ antiport. 5-(N-Methyl-N-isobutyl)­amiloride has been used to study early cellular response to acidosis.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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