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A6140 Sigma

Ampicillin trihydrate

96.0-100.5% anhydrous basis (HPLC)

Synonym: D-(−)-α-Aminobenzylpenicillin

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,
InChI Key   RXDALBZNGVATNY-CWLIKTDRSA-N
assay   96.0-100.5% anhydrous basis (HPLC)
form   powder
pKa (25 °C)   2.5 (COOH)
  7.3 (NH2)
mp   198-200 °C (dec.)(lit.)
solubility   1 M HCl: soluble50 mg/mL
Mode of action   cell wall synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C

Description

Biochem/physiol Actions

A β-lactam antibiotic with an amino group side chain attached to the penicillin structure. Penicillin derivative that inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Bactericidal only to growing Escherichia coli . Mode of resistance: Cleavage of β-lactam ring of ampicillin by β-lactamase. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.

Application

Ampicillin Trihydrate is commonly used to select for ampicillin resistance in mutated and transformed cells.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Price and Availability


Laboratory Gloves
Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
XH8425000
Protocols & Articles
Peer-Reviewed Papers
15

References

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