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A6140 Sigma

Ampicillin trihydrate

96.0-100.5% anhydrous basis (HPLC)

Synonym: D-(−)-α-Aminobenzylpenicillin

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,
InChI Key   RXDALBZNGVATNY-CWLIKTDRSA-N
assay   96.0-100.5% anhydrous basis (HPLC)
form   powder
impurities   ≤15.0% Moisture content (by Karl Fischer)
pKa (25 °C)   2.5 (COOH)
  7.3 (NH2)
mp   198-200 °C (dec.)(lit.)
solubility   1 M HCl: soluble50 mg/mL
Mode of action   cell wall synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C

Description

Biochem/physiol Actions

A β-lactam antibiotic with an amino group side chain attached to the penicillin structure. Penicillin derivative that inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Bactericidal only to growing Escherichia coli . Mode of resistance: Cleavage of β-lactam ring of ampicillin by β-lactamase. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.

Application

Ampicillin Trihydrate is commonly used to select for ampicillin resistance in mutated and transformed cells.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
XH8425000
Protocols & Articles
Peer-Reviewed Papers
15

References

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