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A6397 Sigma

Antithrombin III from rat plasma

lyophilized powder, >200 units/mg protein (E1%/280 = 6.5)

Synonym: Factor Xa inhibitor, Heparin cofactor

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Description

Analysis Note

Homogeneous by gel electrophoresis.

Linkage

Not to be confused with thrombin antiserum.

Reconstitution

When reconstituted with 1.0 ml of deionized water, solution will contain a minimum of the stated activity in 0.1 M sodium chloride, and 0.02 M Tris, pH 7.5.

Unit Definition

One unit is the activity present in 0.1 ml of normal human pooled plasma tested in the presence of 0.1 unit of heparin.

Biochem/physiol Actions

Serine protease inhibitor; Inhibitor of thrombin and activated factor X (Xa). Effective concentration equimolar with proteinase. AT III becomes depleted in sepsis, toxic shock, severe burns, organ failure, and xenotransplantation. AT III supplementation reduces morbidity and mortality in animal models of sepsis and organ failure.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
CD4071900

Documents

Certificate of Analysis

Protocols & Articles

Articles

Plasma Derived Proteins and Enzymes

Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Applications, Gas chromatography, Type

Peer-Reviewed Papers
15

References

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