|Related Categories||AN-AZ, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism,|
|solubility||0.1 M HCl: soluble1 mg/mL|
|methanol: soluble11 mg/mL|
|ethanol: soluble8 mg/mL|
Blocks cGMP production; inhibits intracellular Ca2+ release; blocks the effects of nitric oxide. Inhibits antigen-induced leukotriene release.
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pharmaceutical secondary standard; traceable to USP
≥98% (HPLC), powder
≥98% (HPLC), powder
Evidence that an L-arginine/nitric oxide dependent elevation of tissue cyclic GMP content is involved in depression of vascular reactivity by endotoxin. Fleming, et al. Br. J. Pharmacol. 103, 1047-1052, (1991)
LY-83583 (6-anilino-5,8-quinolinedione) blocks nitrovasodilator-induced cyclic GMP increases and inhibition of platelet activation. Mulsh et al. Naunyn Schmiedebergs Arch. Pharmacol. 340, 119-125, (1989)
Synthetic smooth muscle cell phenotype is associated with increased nicotinamide adenine dinucleotide phosphate oxidase activity: effect on collagen secretion Patel, R., et al. J. Vasc. Surg. 43, 364-71, (2006)
Evidence for the role of phosphatidylcholine-specific phospholipase C in sustained hypoxic pulmonary vasoconstriction. Strielkov IV, Kizub IV, Khromov AS, et al. Vascul. Pharmacol. 58(4), 292-8, (2013)
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Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity. Luo C, Gangadharan V, Bali KK, et al. PLoS Biol. 10(3), e1001283, (2012)
Multiple pathways from three types of sugar receptor sites to metabotropic transduction pathways of the blowfly: study by the whole cell-clamp experiments. Kan H, Kataoka-Shirasugi N, and Amakawa T Comp. Biochem. Physiol. A. Mol. Integr. Physiol. 160(1), 94-9, (2011)
A soluble guanylate cyclase mediates negative signaling by ammonium on expression of nitrate reductase in Chlamydomonas. de Montaigu A, Sanz-Luque E, Galván A, et al. Plant Cell 22(5), 1532-48, (2010)
Involvement of NO and KATP channel in adenosine A2B receptors induced cardiovascular regulation in the posterior hypothalamus of rats. Lee TK and Koh HC J. Cardiovasc. Pharmacol. 53(2), 167-72, (2009)
Modification of the cardiovascular response of posterior hypothalamic adenosine A(2A) receptor stimulation by adenylate cyclase and KATP channel blockade in anesthetized rats. Lee CB and Koh HC Auton. Neurosci. 146(1-2), 70-5, (2009)
Investigation of a possible interaction between the heme oxygenase/biliverdin reductase and nitric oxide synthase pathway in murine gastric fundus and jejunum. De Backer O and Lefebvre RA Eur. J. Pharmacol. 590(1-3), 369-76, (2008)
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