Aflatoxin B1 from Aspergillus flavus from Aspergillus flavus

Properties

Related Categories	A-AM, Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Carcinogens, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Enzymes, Inhibitors, and Substrates, Mold, Neurobiology, Neuroscience, Pharmacologicals, Substrates, Toxins, Toxins and Venoms, Xenobiotics and Drug Metabolism More...
Quality Level	PREMIUM
biological source	from Aspergillus flavus
assay	≥98% (TLC and HPLC)
storage temp.	2-8°C

Description

Warning

Possibly carcinogenic.

Application

Aflatoxin B1 is a carcinogenic compound that induces transversion of G to T at codon 249 of the p53 tumor suppressor gene. Aflatoxin B1 may be used as an internal standard when testing for aflatoxin contamination in food products.

Biochem/physiol Actions

Hepatocarcinogen. Food contaminant produced by Aspergillus flavus, a common soil fungus. Aflatoxin is biotransformed to genotoxic intermediates by P450 Phase I enzymes, mainly CYP3A4 via aflatoxin B1 3-hydroxylation. Detoxification depends on Phase II enzymes, such as Glutathione S-Transferase and AFB(1)-aldehyde reductase (AFAR).

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. A6636.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Price and Availability

Suggested Laboratory Gloves

This substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.

for splash & immersion protection

Related Papers

Mechanism of action of dietary chemoprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism. Manson MM, et al. Carcinogenesis 18, 1729-38, (1997)

Documents

Certificate of Analysis

Certificate of Origin

A6636 - Product Information Sheet (26 KB)

Safety Information

Symbol	GHS06, GHS08
Signal word	Danger
Hazard statements	H300 +H310 + H330-H350
Precautionary statements	P201-P260-P264-P280-P284-P301 + P310
Personal Protective Equipment	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes (Europe)	T+
Risk Statements (Europe)	45-46-26/27/28
Safety Statements (Europe)	53-28-36/37-45
RIDADR	UN 3462 6.1/PG 1
WGK Germany	3
RTECS	GY1925000

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Articles

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
Vicki Caligur
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Transcription, transformation