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A6706 Sigma

O-Acetyl-L-carnitine hydrochloride

≥99% (titration), powder

Synonym: (R)-3-Acetoxy-4-(trimethylammonio)butyrate hydrochloride, ALC, ALCAR, Acetyl L-carnitine HCl, R-(−)-2-Acetyloxy-3-carboxy-N,N,N-trimethyl-1-propanaminium chloride

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Properties

Related Categories Agonists, Amino Acid Library Collection, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   JATPLOXBFFRHDN-DDWIOCJRSA-N
Quality Level   PREMIUM
assay   ≥99% (titration)
form   powder
optical activity   [α]25/D −28°, c = 2 in H2O(lit.)
color   white
solubility   H2O: soluble100 mg/mL
storage temp.   2-8°C

Description

Packaging

1, 5 g in poly bottle

Biochem/physiol Actions

Endogenous mitochondrial metabolite that transports acetyl groups across the mitochondrial membrane. Exogenous acetylcarnitine enhances mitochondrial function in aged rats. As an acetate donor to coenzyme A, it increases the central and peripheral acetylcholine synthesis and function. Acetylcarnitine has antinociceptive activity that may be mediated by enhanced activity of muscarinic cholinergic receptors or mGlu2 glutamate receptors.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Acyl-L-Carnitines

Carnitine was discovered at the beginning of the last century and plays an important role in fatty acid metabolic pathways.1 It acts as a carrier of activated fatty acids across the inner mitochondri...
Keywords: Chromatography, Diseases, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolic Pathways, Metabolism, Separation

Characteristic Metabolites for Inborn Errors of Lipid Metabolism

Hereditary disorders in lipid metabolism include Tay-Sachs disease, Gaucher disease, Niemann-Pick disease, metachromatic leucodystrophy, Fabry disease, Refsum disease, and Tangier disease. These lipi...
Keywords: Degradations, Eliminations, Enzyme activity, Genetic, Lipid Metabolism, Metabolism, Metabolites, Vitamins

LC/MS Analysis of Fourteen Acyl-L-Carnitines on Ascentis® Express OH5

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Fourteen Acyl-L-Carnitines on Ascentis® Express OH5
Keywords: Chromatography, Derivatizations, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolism, Separation

LC/MS Analysis of Seven Acyl-L-Carnitines on Ascentis® Express OH5 (HILIC Mode)

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Seven Acyl-L-Carnitines on Ascentis® Express OH5 (HILIC Mode)
Keywords: Chromatography, Derivatizations, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolism, Separation

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Mitochondrial Dysfunction and Metabolic Defects

Defects in mitochondrial function are associated with insulin resistance in both human and animal studies. Insulin resistance is associated with a decrease in the number, oxidative capacity, size, an...
Keywords: Acetylations, Apoptosis, Biofiles, Cancer, Carboxylations, Catalog, Catalysis, Citric Acid Cycle, Decarboxylations, Degradations, Diabetes, Enzyme-linked immunosorbent assay, Glycolysis, Immunofluorescence, Immunohistochemistry, Lipid Metabolism, Metabolism, Metabolites, Neurotransmitters, Obesity, Oxidations, Phosphorylations, Physiological Processes, Protocols, Transcription, Transduction, Transfection, Western blot

Peer-Reviewed Papers
15

References

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