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A6770 Sigma

Methotrexate hydrate

≥98% (HPLC), powder

Synonym: 4-Amino-10-methylfolic acid hydrate, L-4-Amino-N10-methylpteroylglutamic acid hydrate, L-Amethopterin hydrate, Antifolan hydrate, MTX hydrate, Methylaminopterin hydrate

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Description

Application

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.

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All labs need water

Biomedical Applications
Safety & Documentation

Safety Information

Protocols & Articles

Articles

UHPLC Analysis of Methotrexate and Related Compounds on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Methotrexate and Related Compounds on Ascentis® Express C18
Keywords: Clinical, Pharmaceutical, Separation

Peer-Reviewed Papers
15

References

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