Synonym: 3′,5′-Cyclic AMP sodium salt, cAMP-Na
|Related Categories||A-AM, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism,|
|solubility||H2O: soluble50 mg/mL|
Adenosine-3′,5′-cyclic monophosphate (cAMP) is an activator of cyclic-AMP-dependent protein kinase A (PKA). The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis. Exogneous cAMP plays a role in the spontaneous activity and contraction of the heart muscle.
Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.
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Cyclic AMP-dependent protein kinase (PKA or cAK) and cyclic GMP-dependent protein kinase (PKG or cGK) transfer the γ-phosphate of ATP to serine and threonine residues of many cellular proteins. PKAs ...
Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and/or cGMP. They function with adenylyl and guanylyl cyclases to regulate the amplitude and duration of responses triggere...
Keywords: Amplification, Atomic absorption spectroscopy, Catalysis, Diabetes, Gene expression, Genetic, Hormones, Inflammation, Neurotransmitters, Obesity, Parkinson Disease, Phosphorylations, Physiological Processes, Schizophrenia, Transduction
AMP-activated kinase, AMPK, is involved in the maintenance of plasma membrane organization in boar spermatozoa. Hurtado de Llera A, Martin-Hidalgo D, Rodriguez-Gil JE, et al. Biochim. Biophys. Acta 1828(9), 2143-51, (2013)
Analysis of core circadian feedback loop in suprachiasmatic nucleus of mCry1-luc transgenic reporter mouse. Maywood ES, Drynan L, Chesham JE, et al. Proc. Natl. Acad. Sci. U. S. A. 110(23), 9547-52, (2013)
Sac-1004, a novel vascular leakage blocker, enhances endothelial barrier through the cAMP/Rac/cortactin pathway. Maharjan S, Kim K, Agrawal V, et al. Biochem. Biophys. Res. Commun. 435(3), 420-7, (2013)
Angiotensin II inhibits ADH-stimulated cAMP: role on O2- and transport-related oxygen consumption in the loop of Henle. Silva GB, Juncos LI, Baigorria ST, et al. J. Biol. Regul. Homeost. Agents 27(2), 569-78, (2013)
Discovery of 7-oxopyrazolo[1,5-a]pyrimidine-6-carboxamides as potent and selective CB(2) cannabinoid receptor inverse agonists. Aghazadeh Tabrizi M, Baraldi PG, Saponaro G, et al. J. Med. Chem. 56(11), 4482-96, (2013)
GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Meyer RC, Giddens MM, Schaefer SA, et al. Proc. Natl. Acad. Sci. U. S. A. 110(23), 9529-34, (2013)
Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCFβTRCP ubiquitin E3 ligase. Wiseman SL, Shimizu Y, Palfrey C, et al. J. Biol. Chem. 288(24), 17803-11, (2013)
SAD-A potentiates glucose-stimulated insulin secretion as a mediator of glucagon-like peptide 1 response in pancreatic β cells. Nie J, Lilley BN, Pan YA, et al. Mol. Cell. Biol. 33(13), 2527-34, (2013)
Sustained in vivo blockade of α₁-adrenergic receptors prevented some of stress-triggered effects on steroidogenic machinery in Leydig cells. Stojkov NJ, Janjic MM, Baburski AZ, et al. Am. J. Physiol. Endocrinol. Metab. 305(2), E194-204, (2013)
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