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A6955 Sigma

Angiogenin human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, cell culture tested

Synonym: ANG

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Description

Analysis Note

The activity of human angiogenin is tested in culture by measuring its ribonucleolytic activity for yeast tRNA.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.

Biochem/physiol Actions

Angiogenin, a liver-derived angiogenic factor, is a single chain polypeptide with an isoelectric point of pl >9.5 and a member of the ribonuclease superfamily. Although the ribonucleolytic activity of angiogenin toward most RNase A substrates is lower than that of RNase A, this activity is essential to its angiogenic activity since inhibition of the angiogenin RNase activity will inhibit the angiogenic activity. High affinity receptors for angiogenin are expressed in cultured aortic smooth muscle cells and can be modulated by protamin, heparin and placental ribonuclease inhibitor.

Angiogenin, a liver-derived angiogenic factor, is a single chain polypeptide with an isoelectric point of pl >9.5 and a member of the ribonuclease superfamily.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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