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A7011 Sigma

Alcohol Dehydrogenase from Saccharomyces cerevisiae

lyophilized powder (contains buffer salts), ≥300 units/mg protein

Synonym: ADH, Alcohol Dehydrogenase from yeast, Alcohol:NAD+ oxidoreductase

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Properties

Related Categories 1.1.x.x Acting on hydroxyl groups, 1.x.x.x Oxidoreductases, Alcohol Metabolism, Application Index, Biochemicals and Reagents,
Quality Level   PREMIUM
form   lyophilized powder (contains buffer salts)
purified by   crystallization
solubility   H2O: soluble1.0 mg/mL, clear to slightly hazy, colorless to faintly yellow
  : soluble
Featured Industry   Diagnostic Assay Manufacturing
shipped in   dry ice
storage temp.   −20°C

Description

Caution

Contains bound β-NAD and β-NADH and is not suitable for the recycling microassay of β-NAD and β-NADH. If you require ADH for this purpose, see Catalog No. A3263.

Preparation Note

Dissolves in water at a concentration of 1 mg/mL to form a clear to slightly hazy, colorless to faintly yellow colored solution.

Unit Definition

One unit will convert 1.0 μmole of ethanol to acetaldehyde per min at pH 8.8 at 25 °C.

Physical form

Solids containing ≤ 2% citrate buffer salts

Application

Alcohol dehydrogenase has been used along with lactic dehydrogenase for the enzymatic reduction of acetaldehyde using sodium(R,S)-[2-3H] lactate.1 Ethanol concentration can be determined colorimentrically by monitoring the enzymatic reduction of NAD using alcohol dehydrogenase after preremoval of the aldehyde group.2

Biochem/physiol Actions

A 141 kDa tetramer containing 4 equal subunits. The active site of each subunit contains a zinc atom. Each active site also contains 2 reactive sulfhydryl groups and a histidine residue.

Isoelectric point: 5.4-5.8

Optimal pH: 8.6-9.0

Substrates: Yeast ADH is most active with ethanol and its activity decreases as the size of the alcohol increases or decreases. Branched chain alcohols and secondary alcohols also have very low activity.

KM (ethanol) = 2.1 × 10-2 M
KM (methanol = 1.3 × 10-1 M
KM (isopropanol) = 1.4 × 10-1 M

Inhibitors: Compounds that react with free sulfhydryls, including N-alkylmaleimides and iodoacetamide.
Zinc chelator inhibitors, including 1,10-phenanthroline,
8-hydroxyquinoline, 2,2′-dipyridyl, and thiourea.
Substrate analogue inhibitors, including β-NAD analogs, purine and pyrimidine derivatives, chloroethanol, and fluoroethanol.

Extinction Coefficient: E1% = 14.6 (water, 280 nm)

Price and Availability

TruPAGE™ Pre-cast Polyacrylamide Gels


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≥10,000 units/mL

recombinant, expressed in E. coli, ≥10.0 U/mL

β-Nicotinamide adenine dinucleotide hydrate

≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), ≥96.5% (enzymatic), from yeast

Bovine Serum Albumin

lyophilized powder, ≥96% (agarose gel electrophoresis)

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Safety & Documentation

Safety Information

WGK Germany 
3
RTECS 
SZ5999500

Protocols & Articles

Protocols

Enzymatic Assay Of Alcohol Dehydrogenase Attached To Agarose (A2529)

1. OBJECTIVE The objective of this procedure is to standardize the enzymatic assay of Alcohol Dehydrogenase attached to Agarose, Sigma Product Number (A2529) , at Sigma-Aldrich St. Louis.
Keywords: Extinction coefficient

Enzymatic Assay of Alcohol Dehydrogenase (EC 1.1.1.1)

This procedure may be used for Alcohol Dehydrogenase products, except for Alcohol Dehydrogenase, Insoluble Enzyme attached to beaded agarose (Catalog No. A2529).
Keywords: Extinction coefficient

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Peer-Reviewed Papers

References

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Elusive transition state of alcohol dehydrogenase unveiled Daniel Roston and Amnon Kohen1 Proc. Natl. Acad. Sci. U. S. A. 107, 9572-9577, (2010)

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The gamma 1 and gamma 2 subunits of human liver alcohol dehydrogenase. cDNA structures, two amino acid replacements, and compatibility with changes in the enzymatic properties. Höög JO, Hedén LO, Larsson K, et al. Eur. J. Biochem. 159(2), 215-8, (1986)

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Human liver alcohol dehydrogenase. 1. The primary structure of the beta 1 beta 1 isoenzyme. Hempel J, Bühler R, Kaiser R, et al. Eur. J. Biochem. 145(3), 437-45, (1984)

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Human liver alcohol dehydrogenase. 2. The primary structure of the gamma 1 protein chain. Bühler R, Hempel J, Kaiser R, et al. Eur. J. Biochem. 145(3), 447-53, (1984)

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Alcohol dehydrogenase of class IV (sigma sigma-ADH) from human stomach. cDNA sequence and structure/function relationships. Farrés J, Moreno A, Crosas B, et al. Eur. J. Biochem. 224(2), 549-57, (1994)

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Differences between alcohol dehydrogenases. Structural properties and evolutionary aspects. Jörnvall H Eur. J. Biochem. 72(3), 443-52, (1977)

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Human liver alcohol dehydrogenase: amino acid substitution in the beta 2 beta 2 Oriental isozyme explains functional properties, establishes an active site structure, and parallels mutational exchanges in the yeast enzyme. Jörnvall H, Hempel J, Vallee BL, et al. Proc. Natl. Acad. Sci. U. S. A. 81(10), 3024-8, (1984)

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Mutation of Arg-115 of human class III alcohol dehydrogenase: a binding site required for formaldehyde dehydrogenase activity and fatty acid activation. Engeland K, Höög JO, Holmquist B, et al. Proc. Natl. Acad. Sci. U. S. A. 90(6), 2491-4, (1993)

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cDNA clones coding for the beta-subunit of human liver alcohol dehydrogenase have differently sized 3'-non-coding regions. Hedén LO, Höög JO, Larsson K, et al. FEBS Lett. 194(2), 327-32, (1986)

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Class III human liver alcohol dehydrogenase: a novel structural type equidistantly related to the class I and class II enzymes. Kaiser R, Holmquist B, Hempel J, et al. Biochemistry 27(4), 1132-40, (1988)

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Fouling-induced enzyme immobilization for membrane reactors. Luo J, Meyer AS, Jonsson G, et al. Bioresour. Technol. 147, 260-8, (2013)

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Class IV alcohol dehydrogenase (the gastric enzyme). Structural analysis of human sigma sigma-ADH reveals class IV to be variable and confirms the presence of a fifth mammalian alcohol dehydrogenase class. Parés X, Cederlund E, Moreno A, et al. FEBS Lett. 303(1), 69-72, (1992)

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Alcohol consumption and cognitive impairment in older men: a mendelian randomization study. Almeida OP, Hankey GJ, Yeap BB, et al. Neurology 82(12), 1038-44, (2014)

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Structure of the class II enzyme of human liver alcohol dehydrogenase: combined cDNA and protein sequence determination of the pi subunit. Höög JO, von Bahr-Lindström H, Hedén LO, et al. Biochemistry 26(7), 1926-32, (1987)

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cDNA and protein structure for the alpha subunit of human liver alcohol dehydrogenase. von Bahr-Lindström H, Höög JO, Hedén LO, et al. Biochemistry 25(9), 2465-70, (1986)

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Hydrogen-driven asymmetric reduction of hydroxyacetone to (R)-1,2-propanediol by Ralstonia eutropha transformant expressing alcohol dehydrogenase from Kluyveromyces lactis. Oda T, Oda K, Yamamoto H, et al. Microb. Cell Fact. 12(1), 2, (2013)

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The human beta 3 alcohol dehydrogenase subunit differs from beta 1 by a Cys for Arg-369 substitution which decreases NAD(H) binding. Burnell JC, Carr LG, Dwulet FE, et al. Biochem. Biophys. Res. Commun. 146(3), 1127-33, (1987)

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Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification. Xu YL, Carr LG, Bosron WF, et al. Genomics 2(3), 209-14, (1988)

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[Effect of growth factors and some microelements on biosurfactant synthesis of Acinetobacter calcoaceticus IMV B-7241]. Pirog TP, Shevchuk TA, Mashchenko OIu, et al. Mikrobiol. Z. 75(5), 18-26, (2013)

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[Effect of Cu2+ on synthesis of biosurfactants of Acinetobacter calcoaceticus IMV B-7241 and Rhodococcus erythropolis IMV Ac-5017]. Pirog TP, Konon AD, Sofilkanich AP, et al. Mikrobiol. Z. 75(1), 3-13, (2013)

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[Photo-induced conformational motility of proteins]. Vekshin NL Biofizika 57(5), 741-5, (2012)

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Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study. Ferrari P, McKay JD, Jenab M, et al. Eur. J. Clin. Nutr. 66(12), 1303-8, (2012)

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Cyanobacterial conversion of carbon dioxide to 2,3-butanediol. Oliver JW, Machado IM, Yoneda H, et al. Proc. Natl. Acad. Sci. U. S. A. 110(4), 1249-54, (2013)

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Initial characterization of the human central proteome. Burkard TR, Planyavsky M, Kaupe I, et al. BMC Syst. Biol. 5, 17, (2011)

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Cloning and characterization of the human ADH4 gene. von Bahr-Lindström H, Jörnvall H, and Höög JO Gene 103(2), 269-74, (1991)

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Charge detection mass spectrometry with resolved charge states. Contino NC, Pierson EE, Keifer DZ, et al. J. Am. Soc. Mass Spectrom. 24(1), 101-8, (2013)

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Autophagy protects the retina from light-induced degeneration. Chen Y, Sawada O, Kohno H, et al. J. Biol. Chem. 288(11), 7506-18, (2013)

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Complete oxidation of methanol in biobattery devices using a hydrogel created from three modified dehydrogenases. Kim YH, Campbell E, Yu J, et al. Angew. Chem. Int. Ed. Engl. 52(5), 1437-40, (2013)

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Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence. Ikuta T, Szeto S, and Yoshida A Proc. Natl. Acad. Sci. U. S. A. 83(3), 634-8, (1986)

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A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme. Yasunami M, Chen CS, and Yoshida A Proc. Natl. Acad. Sci. U. S. A. 88(17), 7610-4, (1991)

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Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions. Hurley TD, Bosron WF, Hamilton JA, et al. Proc. Natl. Acad. Sci. U. S. A. 88(18), 8149-53, (1991)

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Structure of a bifunctional alcohol dehydrogenase involved in bioethanol generation in Geobacillus thermoglucosidasius. Extance J, Crennell SJ, Eley K, et al. Acta Crystallogr. D Biol. Crystallogr. 69(Pt 10), 2104-15, (2013)

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Fetal alcohol exposure and IQ at age 8: evidence from a population-based birth-cohort study. Lewis SJ, Zuccolo L, Davey Smith G, et al. PLoS ONE 7(11), e49407, (2012)

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Effect of organic solvents on the activity and stability of halophilic alcohol dehydrogenase (ADH2) from Haloferax volcanii. Alsafadi D and Paradisi F Extremophiles 17(1), 115-22, (2013)

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Molecular cloning of a full-length cDNA for human alcohol dehydrogenase. Ikuta T, Fujiyoshi T, Kurachi K, et al. Proc. Natl. Acad. Sci. U. S. A. 82(9), 2703-7, (1985)

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Molecular analysis of the human class I alcohol dehydrogenase gene family and nucleotide sequence of the gene encoding the beta subunit. Duester G, Smith M, Bilanchone V, et al. J. Biol. Chem. 261(5), 2027-33, (1986)

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Anti-folate combination therapies and their effect on the development of drug resistance in Plasmodium vivax. Ding S, Ye R, Zhang D, et al. Sci. Rep. 3, 1008, (2013)

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Role of UGT1A1 and ADH gene polymorphisms in pegvisomant-induced liver toxicity in acromegalic patients. Filopanti M, Barbieri AM, Mantovani G, et al. Eur. J. Endocrinol. 170(2), 247-54, (2014)

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Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase in biotransformation. Diao X, Deng P, Xie C, et al. Drug Metab. Dispos. 41(2), 430-44, (2013)

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Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase. Active-site amino acid sequence explains substrate specificity compared with liver isozymes. Kedishvili NY, Bosron WF, Stone CL, et al. J. Biol. Chem. 270(8), 3625-30, (1995)

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Human class V alcohol dehydrogenase (ADH5): A complex transcription unit generates C-terminal multiplicity. Strömberg P and Höög JO Biochem. Biophys. Res. Commun. 278(3), 544-9, (2000)

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Genetic engineering of novel bluer-colored chrysanthemums produced by accumulation of delphinidin-based anthocyanins. Noda N, Aida R, Kishimoto S, et al. Plant Cell Physiol. 54(10), 1684-95, (2013)

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The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome. Yasunami M, Kikuchi I, Sarapata D, et al. Genomics 7(2), 152-8, (1990)

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X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity. Xie P, Parsons SH, Speckhard DC, et al. J. Biol. Chem. 272(30), 18558-63, (1997)

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Surface display of a redox enzyme and its site-specific wiring to gold electrodes. Amir L, Carnally SA, Rayo J, et al. J. Am. Chem. Soc. 135(1), 70-3, (2013)

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The genes for human alcohol dehydrogenases beta 1 and beta 2 differ by only one nucleotide. Matsuo Y, Yokoyama R, and Yokoyama S Eur. J. Biochem. 183(2), 317-20, (1989)

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Parasite infections in multiple sclerosis modulate immune responses through a retinoic acid-dependent pathway. Correale J and Farez MF J. Immunol. 191(7), 3827-37, (2013)

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The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase) determined from the ADH7 gene. Satre MA, Zgombić-Knight M, and Duester G J. Biol. Chem. 269(22), 15606-12, (1994)

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Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences. Hurley TD, Bosron WF, Stone CL, et al. J. Mol. Biol. 239(3), 415-29, (1994)

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Structure of human chi chi alcohol dehydrogenase: a glutathione-dependent formaldehyde dehydrogenase. Yang ZN, Bosron WF, and Hurley TD J. Mol. Biol. 265(3), 330-43, (1997)

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SAGA complex components and acetate repression in Aspergillus nidulans. Georgakopoulos P, Lockington RA, and Kelly JM G3 (Bethesda) 2(11), 1357-67, (2012)

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Zinc-dependent regulation of the Adh1 antisense transcript in fission yeast. Ehrensberger KM, Mason C, Corkins ME, et al. J. Biol. Chem. 288(2), 759-69, (2013)

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Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human small intestine. Chiang CP, Wu CW, Lee SP, et al. Alcohol. Clin. Exp. Res. 36(12), 2047-58, (2012)

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X-ray structure of human beta3beta3 alcohol dehydrogenase. The contribution of ionic interactions to coenzyme binding. Davis GJ, Bosron WF, Stone CL, et al. J. Biol. Chem. 271(29), 17057-61, (1996)

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Molecular cloning and chromosomal localization of the ADH7 gene encoding human class IV (sigma) ADH. Yokoyama H, Baraona E, and Lieber CS Genomics 31(2), 243-5, (1996)

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A critical test of the "tunneling and coupled motion" concept in enzymatic alcohol oxidation. Roston D and Kohen A J. Am. Chem. Soc. 135(37), 13624-7, (2013)

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Genomic structure and expression of the ADH7 gene encoding human class IV alcohol dehydrogenase, the form most efficient for retinol metabolism in vitro. Zgombić-Knight M, Foglio MH, and Duester G J. Biol. Chem. 270(9), 4305-11, (1995)

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Taurine and Chinese traditional medicine accelerate alcohol metabolism in mice. Wu G, Yang J, Lin S, et al. Adv. Exp. Med. Biol. 776, 21-8, (2013)

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A new regulatory pathway of mRNA export by an F-box protein, Mdm30. Durairaj G, Lahudkar S, and Bhaumik SR RNA 20(2), 133-42, (2014)

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An improved chemically inducible gene switch that functions in the monocotyledonous plant sugar cane. Kinkema M, Geijskes RJ, Shand K, et al. Plant Mol. Biol. 84(4-5), 443-54, (2014)

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Molecular structure of the human alcohol dehydrogenase 1 gene. Matsuo Y and Yokoyama S FEBS Lett. 243(1), 57-60, (1989)

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Polymorphisms in alcohol-metabolizing enzymes and esophageal carcinoma susceptibility: a Dutch Caucasian case-control study. Dura P, Berkers T, van Veen EM, et al. J. Hum. Genet. 58(11), 742-8, (2013)

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Kinetic isotope effects as a probe of hydrogen transfers to and from common enzymatic cofactors. Roston D, Islam Z, and Kohen A Arch. Biochem. Biophys. 544, 96-104, (2014)

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cDNA sequence of human class III alcohol dehydrogenase. Sharma CP, Fox EA, Holmquist B, et al. Biochem. Biophys. Res. Commun. 164(2), 631-7, (1989)

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Molecular structure of the human alcohol dehydrogenase 3 gene. Yokoyama S, Matsuo Y, Rajasekharan S, et al. Jpn. J. Genet. 67(2), 167-71, (1992)

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Three-dimensional structures of the three human class I alcohol dehydrogenases. Niederhut MS, Gibbons BJ, Perez-Miller S, et al. Protein Sci. 10(4), 697-706, (2001)

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Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase. Hur MW and Edenberg HJ Gene 121(2), 305-11, (1992)

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Cloning and comparative mapping of a human class III (chi) alcohol dehydrogenase cDNA. Giri PR, Krug JF, Kozak C, et al. Biochem. Biophys. Res. Commun. 164(1), 453-60, (1989)

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Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier LW, Graves TA, Fulton RS, et al. Nature 434(7034), 724-31, (2005)

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Effects of cavities at the nicotinamide binding site of liver alcohol dehydrogenase on structure, dynamics and catalysis. Yahashiri A, Rubach JK, and Plapp BV Biochemistry 53(5), 881-94, (2014)

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The bifunctional aldehyde-alcohol dehydrogenase controls ethanol and acetate production in Entamoeba histolytica under aerobic conditions. Pineda E, Encalada R, Olivos-García A, et al. FEBS Lett. 587(2), 178-84, (2013)

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Metabolic remodeling in frataxin-deficient yeast is mediated by Cth2 and Adr1. Moreno-Cermeño A, Alsina D, Cabiscol E, et al. Biochim. Biophys. Acta 1833(12), 3326-37, (2013)

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The role of aldehyde/alcohol dehydrogenase (AdhE) in ethanol production from glycerol by Klebsiella pneumoniae. Oh BR, Hong WK, Heo SY, et al. J. Ind. Microbiol. Biotechnol. 40(2), 227-33, (2013)

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The RNA polymerase II C-terminal domain-interacting domain of yeast Nrd1 contributes to the choice of termination pathway and couples to RNA processing by the nuclear exosome. Heo DH, Yoo I, Kong J, et al. J. Biol. Chem. 288(51), 36676-90, (2013)

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Isolation of an alcohol dehydrogenase cDNA from and characterization of its expression in chrysanthemum under waterlogging. Yin D, Ni D, Song L, et al. Plant Sci. 212, 48-54, (2013)

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Green tea extract (Camellia sinensis) fermented by Lactobacillus fermentum attenuates alcohol-induced liver damage. Park JH, Kim Y, and Kim SH Biosci. Biotechnol. Biochem. 76(12), 2294-300, (2012)

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Inhibition of CYP2E1 leads to decreased malondialdehyde-acetaldehyde adduct formation in VL-17A cells under chronic alcohol exposure. Swaminathan K, Clemens DL, and Dey A Life Sci. 92(6-7), 325-36, (2013)

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Role of arginine 115 in fatty acid activation and formaldehyde dehydrogenase activity of human class III alcohol dehydrogenase. Holmquist B, Moulis JM, Engeland K, et al. Biochemistry 32(19), 5139-44, (1993)

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Molecular characterization of a class IV human alcohol dehydrogenase gene (ADH7). Yokoyama S, Matsuo Y, Ramsbotham R, et al. FEBS Lett. 351(3), 411-5, (1994)

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Methionine-141 directly influences the binding of 4-methylpyrazole in human sigma sigma alcohol dehydrogenase. Xie PT and Hurley TD Protein Sci. 8(12), 2639-44, (1999)

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ADH IB expression, but not ADH III, is decreased in human lung cancer. Mutka SC, Green LH, Verderber EL, et al. PLoS ONE 7(12), e52995, (2012)

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Purification of yeast alcohol dehydrogenase by using immobilized metal affinity cryogels. Akduman B, Uygun M, Uygun DA, et al. Mater. Sci. Eng. C. Mater. Biol. Appl. 33(8), 4842-8, (2013)

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Human stomach class IV alcohol dehydrogenase: molecular genetic analysis. Cheung B, Anderson JK, Holmes RS, et al. Alcohol. Clin. Exp. Res. 19(1), 185-6, (1995)

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Nucleotide sequence of the ADH2(3) gene encoding the human alcohol dehydrogenase beta 3 subunit. Carr LG, Xu Y, Ho WH, et al. Alcohol. Clin. Exp. Res. 13(4), 594-6, (1989)

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Structure of three class I human alcohol dehydrogenases complexed with isoenzyme specific formamide inhibitors. Gibbons BJ and Hurley TD Biochemistry 43(39), 12555-62, (2004)

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Iron-mediated effect of alcohol on hepatocyte differentiation in HepaRG cells. Do TH, Gaboriau F, Cannie I, et al. Chem. Biol. Interact. 206(2), 117-25, (2013)

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Effects of the extracts and an active compound curcumenone isolated from Curcuma zedoaria rhizomes on alcohol-induced drunkenness in mice. Kimura Y, Sumiyoshi M, and Tamaki T Fitoterapia 84, 163-9, (2013)

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NAD(+)-linked alcohol dehydrogenase 1 regulates methylglyoxal concentration in Candida albicans. Kwak MK, Ku M, and Kang SO FEBS Lett. 588(7), 1144-53, (2014)

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Biocatalytic characterization of a short-chain alcohol dehydrogenase with broad substrate specificity from thermophilic Carboxydothermus hydrogenoformans. Zhou S, Zhang SC, Lai DY, et al. Biotechnol. Lett. 35(3), 359-65, (2013)

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Locally-generated acetaldehyde is involved in ethanol-mediated LTP inhibition in the hippocampus. Tokuda K, Izumi Y, and Zorumski CF Neurosci. Lett. 537, 40-3, (2013)

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The diagnostic value of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase measurement in the sera of patients with endometrial cancer. Orywal K, Jelski W, Zdrodowski M, et al. Anticancer Res. 33(9), 3725-30, (2013)

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Genetic polymorphisms of pharmacogenomic VIP variants in the Kyrgyz population from northwest China. Yunus Z, Liu L, Wang H, et al. Gene 529(1), 88-93, (2013)

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Proteomic analysis reveals that Adh1p is involved in a synergistic fluconazole and tetrandrine mechanism against Candida albicans. Zhang XL, Zhang GH, Wang ZY, et al. Pharmazie 68(12), 951-4, (2013)

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The alcohol dehydrogenase isoenzyme (ADH IV) as a candidate tumour marker of esophageal cancer. Jelski W, Laniewska-Dunaj M, Niklinski J, et al. Acta Biochim. Pol. 60(3), 489-93, (2013)

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[Polymorphism of ethanol metabolism genes in alcoholic chronic pancreatitis]. Gubergrits NB, Kishenya MS, and Golubova OA Ter. Arkh. 86(2), 49-55, (2014)

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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard, DS. Genome Res. 14, 2121-7, (2004)

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Kinetics and equilibria in the liver alcohol dehydrogenase system. THEORELL H Adv. Enzymol. Relat. Subj. Biochem. 20, 31-49, (1958)

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