• USA Home
  • A7015 - N-(2-Fluorenyl)acetamide

EMAIL THIS PAGE TO A FRIEND
A7015 Sigma

N-(2-Fluorenyl)acetamide

≥98% (HPLC)

Synonym: 2-AAF, 2-Acetamidofluorene, N-Acetyl-2-aminofluorene

Purchase

Properties

Related Categories Cancer Research, Carcinogens, Cell Biology More...
InChI Key   CZIHNRWJTSTCEX-UHFFFAOYSA-N
assay   ≥98% (HPLC)
mp   192-196 °C(lit.)

Description

Biochem/physiol Actions

A genotoxic carcinogen that is used to model liver carcinogenesis in rat. When N-hydroxylated by cytochrome CYP1A2 in the liver, 2-AAF forms adducts with DNA and is tumorigenic in liver and bladder.

Packaging

5, 25 g in glass bottle

Application

N-(2-Fluorenyl)acetamide (2-Acetamidofluorene, 2-AAF), a genotoxic carcinogen, is used to induce liver cancer in animal models such as the 2-AAF/partial hepatectomy rat. 2-AAF may be used to study the mechanism of liver carcinogenesis and as a reference material during its identification or quantitation.

Price and Availability


Discover the Milli-Q® IQ 7000 ultrapure water system
Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
AB9450000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
Vicki Caligur
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Biofiles, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Events, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Sequences, Transcription, Type, transformation

DNA Damage and Repair

Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Degradations, Eliminations, Environmental, Enzymology, Gene expression, Genetic, Infrared spectroscopy, Metabolites, Methylations, Mutagens, Oncology, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription, transformation

Related Content

Carcinogen Selector - Digestive System - Liver

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Digestive System - Liver
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Endocrine System - Liver Endocrine

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Endocrine System - Liver Endocrine
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Endocrine System - Mammary Gland

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Endocrine System - Mammary Gland
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Endocrine System

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Endocrine System
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Integumentary System - Skin

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Integumentary System - Skin
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Integumentary System

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Integumentary System
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Reproductive System - Urinary Bladder

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Reproductive System - Urinary Bladder
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Urinary System

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Urinary System
Keywords: Cancer, Carcinogens, Respiratory

Peer-Reviewed Papers
15

References

Set your institution to view full text papers.
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?