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A7094 Sigma

L-Asparagine monohydrate

from non-animal source, BioReagent, suitable for cell culture, ≥98.0%

Synonym: (S)-2-Aminosuccinic acid 4-amide, (S)-(+)-2-Aminosuccinamic acid, L-Aspartic acid 4-amide



Related Categories Amino Acids, Amino Acids & Vitamins, Amino Acids and Vitamins, Cell Culture, Core Bioreagents,
biological source   from non-animal source
product line   BioReagent
assay   ≥98.0%
form   powder
impurities   endotoxin, tested
mp   233-235 °C(lit.)
solubility   H2O: soluble20 mg/mL
suitability   suitable for cell culture



1 kg in poly bottle

25, 100 g in poly bottle

Biochem/physiol Actions

L-Asparagine, a proteinogenic amino acid, from non-animal source is used in biomanufacturing cell culture systems for the production of therapeutic recombinant proteins and monoclonal antibodies.

General description

The amino acid L-asparagine is a structural analog of L-aspartic acid, where the side chain of the carboxylic acid moiety is amidated, to give a terminal amine group. This renders L-asparagine neutral at physiological pH. The amide group of asparagine is derived from glutamine, in the reaction of aspartate and glutamine in the presence of ATP to yield asparagine and glutamate. In vivo, asparagine is hydrolyzed to aspartate and NH4+ by asparaginase. Asparagine is also an important amino acid in glycopeptide bonds, via N-glycosyl linkages to the sugar rings.

L-Asparagine is used in cell culture media and is a component of MEM non-essential amino acids solution. L-Asparagine has been shown to enhance ornithine decarboxylase activity in cultured human colon adenocarcinoma Caco-2 cells and in cultured IEC-6 intestinal epithelial cells. Spore germination in Bacillus subtilis has been increased in the presence of L-asparagine.

An isoxazoline RGD mimic platelet GPIIb/IIIa antagonist has been prepared by chiral synthesis with L-asparagine as a starting material. L-Asparagine has been utilized in the synthesis of 4-azalysine building blocks for application to combinatorial chemistry.

Price and Availability

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Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers


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A8381 L-Asparagine monohydrate, ≥99% (TLC)

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