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A7191 Sigma

N-Acetyl-D-sphingosine

≥97% (TLC), powder

Synonym: (2S,3R,4E)-2-(Acetylamino)-4-octadecene-1,3-diol, N-Acetoyl-D-erythro-sphingosine, Acetyl ceramide, C2 Ceramide (d18:1/2:0), C2 ceramide

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Properties

Related Categories A-AM, Anti-Proliferative Agents, Antitumor Agents, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
biological source   semisynthetic
InChI Key   BLTCBVOJNNKFKC-HEQKZDDYSA-N
assay   ≥97% (TLC)
form   powder
color   white
solubility   DMSO: soluble
  ethanol: soluble
storage temp.   −20°C

Description

Biochem/physiol Actions

Cell-permeable, biologically active ceramide. It induces differentiation and apoptosis in cells and has been shown to activate protein phosphatases.

Packaging

1, 5 mg in glass bottle

Preparation Note

Prepared from D-sphingosine from bovine brain cerebrosides.

Application

N-Acetyl-D-sphingosine is a cell-permeable and biologically active ceramide. N-Acetyl-D-sphingosine induces differentiation and apoptosis in cells. N-Acetyl-D-sphingosine produces concentration-dependent impairment of vasorelaxation in response to the endothelium-dependent agonist acetylcholine in nontransgenic mice.

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Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
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Protocols & Articles
Peer-Reviewed Papers
15

References

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