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  • A7310 - Anti-Water Channel Aquaporin 2 antibody produced in rabbit

A7310 Sigma

Anti-Water Channel Aquaporin 2 antibody produced in rabbit

IgG fraction of antiserum, lyophilized powder



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Aquaporin (Water) Channels, Antibodies to Ion Channels,
species reactivity   rat, human
application(s)   immunohistochemistry: suitable
  western blot (chemiluminescent): 1:200-1:1000
clone   polyclonal
antibody form   IgG fraction of antiserum
form   lyophilized powder
storage temp.   −20°C
Gene Information   human ... AQP2(359)
mouse ... Aqp2(11827)
rat ... Aqp2(25386)
biological source   rabbit
conjugate   unconjugated



synthetic peptide corresponding to amino acids 254-271 of rat or mouse aquaporin 2 (with additional N-terminal lysine and tyrosine) conjugated to KLH with glutaraldehyde. The epitope is identical in rat and mouse and highly conserved in human.

General description

Aquaporin 2 (AQP2) is a water channel protein that regulates water balance in renal connecting tubules and collecting ducts. AQP2 is activated by anti-diuretic hormone and subsequently facilitates water inflow in renal cells. This protein also interacts with integrin to modulate epithelial cell morphogenesis and cell movement . Anti-Water Channel Aquaporin 2 antibody recognizes aquaporin 2 from rat by immunoblotting. The antibody also reacts with mouse and human AQP2.

Physical form

Lyophilized from a solution containing phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide.

Preparation Note

Isolated on immobilized Protein A


Anti-Water Channel Aquaporin 2 antibody is also suitable for use in chemiluminescent western blot (1:200-1:1000), and immunoblot.

Immunohistochemistry was performed on 10% formalin-fixed parraffin embedded rat kidney sections using rabbit anti-AQP2 at a concentration of 5μg/ml. Use of anti-AQP2 allowed visualization of the medullary thick ascending limb and collecting ducts.

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Safety Information

Symbol  GHS06  GHS06
Signal word  Danger
Hazard statements  H301 + H311-H412
Precautionary statements  P273-P280-P301 + P310 + P330-P302 + P352 + P312
Supplemental Hazard Statements  Contact with acids liberates very toxic gas.
Personal Protective Equipment  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
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