Synonym: 3α,17β-Dihydroxy-5α-androstane, Dihydroandrosterone
|Related Categories||AN-AZ, Androgen, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,|
|drug control||USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada|
|Gene Information||rat ... Ar(24208)|
Dihydroandrosterone is a testosterone metabolite; affects sperm maturation and survival.
5α-Androstane-3α,17β-diol (dihydroandrosterone) is a testosterone metabolite. Dihyroandrosterone inhibited the cell growth of seven cancer cell lines while showing weak toxicity on normal cell lines.
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Synthesis of testosterone and 5alpha-androstanediols during nutritionally stimulated gonadal growth in Lytechinus variegatus lamarck (Echinodermata:Echinoidea). Wasson, K.M., et al. Gen. Comp. Endocrinol. 111, 197, (1998)
An improved hollow fiber solvent-stir bar microextraction for the preconcentration of anabolic steroids in biological matrix with determination by gas chromatography-mass spectrometry Liu, W., et al. J. Chromatogr. A. 1233, 1-7, (2012)
The identification and simultaneous quantification of neuroactive androstane steroids and their polar conjugates in the serum of adult men, using gas chromatography-mass spectrometry. Kancheva L, Hill M, Vceláková H, et al. Steroids 72(11-12), 792-801, (2007)
Effect of testosterone, its 5 alpha-reduced metabolites and the corresponding propionates on testosterone metabolism. I--In the hypothalamus and in the anterior pituitary. Celotti F, Farina JM, Santaniello E, et al. J. Steroid Biochem. 11(1A), 215-9, (1979)
Androstanediol glucuronide production in human liver, prostate, and skin. Evidence for the importance of the liver in 5 alpha-reduced androgen metabolism. Rittmaster RS, Zwicker H, Thompson DL, et al. J. Clin. Endocrinol. Metab. 76(4), 977-82, (1993)
Effect of testosterone, its 5 alpha-reduced metabolites and the corresponding propionates on testosterone metabolism--II. In the ventral prostate and in the seminal vesicles. Celotti F, Farina JM, Santaniello E, et al. J. Steroid Biochem. 11(1A), 221-5, (1979)
Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. Hiroyuki Sato et al J. Med. Chem. 51, 1831-41, (2008)
Chemometric and chemoinformatic analyses of anabolic and androgenic activities of testosterone and dihydrotestosterone analogues. Yoanna María Alvarez-Ginarte et al Bioorg. Med. Chem. 16, 6448-59, (2008)
Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone. Edith Bellavance et al J. Med. Chem. 52, 7488-502, (2009)
17α-ethynyl-5α-androstane-3α, 17β-diol treatment of MNU-induced mammary cancer in rats Ahlem, C., et al. Int. J. Breast Cancer, doi: 10.4061/2011/618757, (2011)
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