5α-Androstane-3α,17β-diol

Properties

Related Categories	AN-AZ, Androgen, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Steroid Hormones More...
drug control	USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada
Gene Information	rat ... Ar(24208)

Description

Biochem/physiol Actions

Dihydroandrosterone is a testosterone metabolite; affects sperm maturation and survival.

Application

5α-Androstane-3α,17β-diol (dihydroandrosterone) is a testosterone metabolite. Dihyroandrosterone inhibited the cell growth of seven cancer cell lines while showing weak toxicity on normal cell lines.

Price and Availability

Related Papers

Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenases from rat and human prostate. Biswas, M.G., et al. J. Biol. Chem. 272, 15959, (1997)

Documents

Certificate of Analysis

Certificate of Origin

FT-IR Condensed Phase

FT-IR Raman

FT-NMR

Safety Information

Personal Protective Equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany	3
RTECS	BV8044310

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Papers

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Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenases from rat and human prostate. Biswas, M.G., et al. J. Biol. Chem. 272, 15959, (1997)

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Seasonal variations in sex steroids and male sexual characteristics in Scyliorhinus canicula. Garnier, D.H., et al. Gen. Comp. Endocrinol. 116, 281, (1999)

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Synthesis of testosterone and 5alpha-androstanediols during nutritionally stimulated gonadal growth in Lytechinus variegatus lamarck (Echinodermata:Echinoidea). Wasson, K.M., et al. Gen. Comp. Endocrinol. 111, 197, (1998)

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An improved hollow fiber solvent-stir bar microextraction for the preconcentration of anabolic steroids in biological matrix with determination by gas chromatography-mass spectrometry Liu, W., et al. J. Chromatogr. A. 1233, 1-7, (2012)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. Hiroyuki Sato et al J. Med. Chem. 51, 1831-41, (2008)

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An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin. Artem Cherkasov et al J. Med. Chem. 51, 2047-56, (2008)

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Chemometric and chemoinformatic analyses of anabolic and androgenic activities of testosterone and dihydrotestosterone analogues. Yoanna María Alvarez-Ginarte et al Bioorg. Med. Chem. 16, 6448-59, (2008)

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Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone. Edith Bellavance et al J. Med. Chem. 52, 7488-502, (2009)

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17α-ethynyl-5α-androstane-3α, 17β-diol treatment of MNU-induced mammary cancer in rats Ahlem, C., et al. Int. J. Breast Cancer, doi: 10.4061/2011/618757, (2011)

Biological evaluation of a new family of aminosteroids that display a selective toxicity for various malignant cell lines Jegham, H., et al. Anti-Cancer Drugs 23(8), 803-14, (2012)

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