|Related Categories||A-AM, Amiloride and Derivatives, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,|
|solubility||H2O: soluble0.3 mg/mL|
|ethanol: soluble35 mg/mL|
Aconitine is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization and blocking the release of neurotransmitters. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection.
Neurotoxin. Activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection. In cultured ventricular myocytes, aconitine increases the duration of the action potential and induces the appearance of early after depolarization.
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|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T+|
|Risk Statements (Europe)||26/28|
|Safety Statements (Europe)||24-45|
|RIDADR||UN 1544 6.1/PG 1|
Voltage-gated sodium channels are present in most excitable cell membranes and play an important role in generating action potentials. A variety of toxins and chemicals are known to either block or m...
Keywords: Analgesics, Atomic absorption spectroscopy, Central Nervous System, Gene expression, Insecticides, Neurotoxins
Different effects on [3H]noradrenaline uptake of the Aconitum alkaloids aconitine, 3-acetylaconitine, lappaconitine, and N-desacetyllappaconitine in rat hippocampus. Seitz, U., and Ameri, A Biochem. Pharmacol. 55, 883-888, (1998)
Effects of arrhythmic agents and Mg2+ on aconitine-induced arrhythmias. Sawanobori, T. Jpn. Heart J. 5, 709, (1996)
Preparation of Fe3O4 nanoparticle enclosure hydroxylated multi-walled carbon nanotubes for the determination of aconitines in human serum samples Zhang, H.F. and Shi, Y.P. Anal. Chim. Acta 724, 54-60, (2012)
Neutral fragment filtering for rapid identification of new diester-diterpenoid alkaloids in roots of Aconitum carmichaeli by ultra-high-pressure liquid chromatography coupled with linear ion trap-orbitrap mass spectrometry. Zhang J, Huang ZH, Qiu XH, et al. PLoS ONE 7(12), e52352, (2012)
3,4-Methylenedioxy-methamphetamine induces in vivo regional up-regulation of central nicotinic receptors in rats and potentiates the regulatory effects of nicotine on these receptors. Pubill D, Garcia-Ratés S, Camarasa J, et al. Neurotoxicology 35, 41-9, (2013)
The role of efflux transporters on the transport of highly toxic aconitine, mesaconitine, hypaconitine, and their hydrolysates, as determined in cultured Caco-2 and transfected MDCKII cells. Ye L, Yang X, Yang Z, et al. Toxicol. Lett. 216(2-3), 86-99, (2013)
Fingerprint analysis of Radix Aconiti using ultra-performance liquid chromatography-electrospray ionization/ tandem mass spectrometry (UPLC-ESI/MS n) combined with stoichiometry. Zhu H, Wang C, Qi Y, et al. Talanta 103, 56-65, (2013)
Presynaptic α4β2 nicotinic acetylcholine receptors increase glutamate release and serotonin neuron excitability in the dorsal raphe nucleus. Garduño J, Galindo-Charles L, Jiménez-Rodríguez J, et al. J. Neurosci. 32(43), 15148-57, (2012)
The exposure of highly toxic aconitine does not significantly impact the activity and expression of cytochrome P450 3A in rats determined by a novel ultra performance liquid chromatography-tandem mass spectrometric method of a specific probe buspirone. Zhu L, Yang X, Zhou J, et al. Food Chem. Toxicol. 51, 396-403, (2013)
[Comparison of content of total alkaloids and aconitine in Aconitum szechenyianum from different producing areas on basis of macroporous adsorption resin purification technology]. Lin L, Wei XM, Wang YH, et al. Zhongguo Zhong Yao Za Zhi 38(7), 995-9, (2013)
Development and assessment of a complete-detoxication strategy for Fuzi (lateral root of Aconitum carmichaeli) and its application in rheumatoid arthritis therapy. Tong P, Wu C, Wang X, et al. J. Ethnopharmacol. 146(2), 562-71, (2013)
In hippocampal oriens interneurons anti-Hebbian long-term potentiation requires cholinergic signaling via α7 nicotinic acetylcholine receptors. Griguoli M, Cellot G, and Cherubini E J. Neurosci. 33(3), 1044-9, (2013)
Study on the aconitine-type alkaloids of Radix Aconiti Lateralis and its processed products using HPLC-ESI-MS(n). Liu, Y., et al. Drug Test. Anal., doi: 10.1002/dta.416., (2012)
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