|Related Categories||A-AM, Amiloride and Derivatives, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,|
|solubility||H2O: soluble0.3 mg/mL|
|ethanol: soluble35 mg/mL|
Aconitine is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization and blocking the release of neurotransmitters. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection.
Neurotoxin. Activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection. In cultured ventricular myocytes, aconitine increases the duration of the action potential and induces the appearance of early after depolarization.
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|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T+|
|Risk Statements (Europe)||26/28|
|Safety Statements (Europe)||24-45|
|RIDADR||UN 1544 6.1/PG 1|
Different effects on [3H]noradrenaline uptake of the Aconitum alkaloids aconitine, 3-acetylaconitine, lappaconitine, and N-desacetyllappaconitine in rat hippocampus. Seitz, U., and Ameri, A Biochem. Pharmacol. 55, 883-888, (1998)
Effects of arrhythmic agents and Mg2+ on aconitine-induced arrhythmias. Sawanobori, T. Jpn. Heart J. 5, 709, (1996)
Preparation of Fe3O4 nanoparticle enclosure hydroxylated multi-walled carbon nanotubes for the determination of aconitines in human serum samples Zhang, H.F. and Shi, Y.P. Anal. Chim. Acta 724, 54-60, (2012)
Study on the aconitine-type alkaloids of Radix Aconiti Lateralis and its processed products using HPLC-ESI-MS(n). Liu, Y., et al. Drug Test. Anal., doi: 10.1002/dta.416., (2012)
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