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A8001 Sigma

Aconitine

≥95% (HPLC), crystalline

Synonym: Acetylbenzoylaconine

Properties

Related Categories A-AM, Amiloride and Derivatives, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥95% (HPLC)
form   crystalline
color   white
solubility   H2O: soluble0.3 mg/mL
  ethanol: soluble35 mg/mL

Description

Packaging

5, 25, 100, 250 mg in glass bottle

Application

Aconitine is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization and blocking the release of neurotransmitters. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection.

Biochem/physiol Actions

Neurotoxin. Activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection. In cultured ventricular myocytes, aconitine increases the duration of the action potential and induces the appearance of early after depolarization.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®,1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability

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