Aconitine
≥95% (HPLC), crystalline
DOWNLOAD MSDS (PDF)Synonym: Acetylbenzoylaconine
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CAS Number 302-27-2
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Empirical Formula (Hill Notation) C34H47NO11
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Molecular Weight 645.74
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Beilstein Registry Number 74608
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EC Number 206-121-7
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MDL number MFCD00082375
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PubChem Substance ID 24891304
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Popular Documents: Product Information Sheet (PDF) | FTIR (PDF)
Properties
| Related Categories | A-AM, Amiloride and Derivatives, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, |
| assay | ≥95% (HPLC) |
| form | crystalline |
| color | white |
| solubility | H2O: soluble0.3 mg/mL |
| ethanol: soluble35 mg/mL |
Description
Application
Aconitine is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization and blocking the release of neurotransmitters. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection.
Biochem/physiol Actions
Neurotoxin. Activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection. In cultured ventricular myocytes, aconitine increases the duration of the action potential and induces the appearance of early after depolarization.
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