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  • A8081 - Anti-Activin Receptor IIA antibody produced in goat

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A8081 Sigma

Anti-Activin Receptor IIA antibody produced in goat

affinity isolated antibody, lyophilized powder

Properties

Related Categories AC-AC, Activins, Activins and Inhibins, Alphabetical Index, Antibodies,
species reactivity   human
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 15 μg/mL
  indirect ELISA: 0.5-1.0 μg/mL
  western blot: 0.1-0.2 μg/mL
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   human ... ACVR2A(92)
biological source   goat
conjugate   unconjugated

Description

Immunogen

recombinant human activin receptor IIA expressed in Sf 21 insect cells.

General description

Activin is a disulfide-linked dimeric protein released by granulosa cells in the ovary and sertoli cells in the testis. It has several functions which include bone remodeling, neural cell differentiation, reproductive physiology, hematopoiesis and mesoderm induction. Activin will not bind directly to Type I activin receptors rather it will associate with the type II receptor-activin complex and start signal transduction. Activin Receptor IIA belongs to Ser/Thr protein kinase family, is highly conserved and can bind to inhibin, BMP-2, and BMP-7 with lower affinities. Goat anti-activin receptor IIA antibody reacts specifically with recombinant human activin receptor IIA. The antibody exhibits approximately 2% cross-reactivity with recombinant human activin receptor I and recombinant human activin receptor IIB.

The antibody has the ability to block receptor-ligand interaction. In ELISA assays, it will block 50% of the binding of recombinant human activin A to recombinant human activin receptor IIA/Fc chimera.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Application

Anti-Activin Receptor IIA antibody can be used in in western blotting (working concentration:-0.1-0.2 μg/mL) and indirect ELISA (working concentration -0.5-1.0 μg/mL) for detecting human activin receptor IIA.

Goat Activin Receptor IIA antibody is suitable for immunohistochemistry assays at 15μg/ml.

Goat anti-Activin receptor IIB (ActRIIB) was used to detect activin receptor IIB in muscle fibroblasts by western blot. The antibody recognized activin receptor IIB at roughly 50kDa.

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