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A8208 Sigma

Atrial Natriuretic Peptide rat

≥97% (HPLC)

Synonym: α-Atriopeptin, rat, α-rANP, ANF (123-150), rat, ANF 1-28, rANP

  • CAS Number 88898-17-3

  • Empirical Formula (Hill Notation) C128H205N45O39S2

  • Molecular Weight 3062.41

  •  MDL number MFCD00076228


Related Categories Cell Biology, Cell Signaling and Neuroscience, Natriuretic Peptides, Neuropeptides, Peptides and Proteins,
assay   ≥97% (HPLC)
composition   Peptide content, ≥70%
storage temp.   −20°C
Gene Information   rat ... Nppa(24602)


Amino Acid Sequence

Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr [Disulfide bridge: 7-23]

Biochem/physiol Actions

Atrial natriuretic peptide (ANP) is synthesized in myoendocrine cells of the heart from which it is released into the circulation. It exerts natriuretic, diuretic, and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure homeostasis.

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