AGK2
≥97% (HPLC), powder
DOWNLOAD MSDS (PDF)Synonym:
2-
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CAS Number 304896-28-4
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Empirical Formula (Hill Notation) C23H13Cl2N3O2
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Molecular Weight 434.27
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MDL number MFCD01909444
Properties
| Related Categories | A-AM, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators, |
| assay | ≥97% (HPLC) |
| form | powder |
| solubility | DMSO: soluble2 mg/mL, clear (warmed) |
| H2O: insoluble | |
| storage temp. | room temp |
Description
Application
AGK2 is a SIRT2 inhibitor. AGK2 has been used in a study to determine that SIRT2 inhibition induces cell death and decreases the intracellular ATP level. AGK2 also rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models.
Biochem/physiol Actions
AGK2 is a SIRT2 inhibitor. AGK2 rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models. IC50 for SIRT2 = 3.5 uM. AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRT3. AGK2 may be the most selective SIRT2 inhibitor available.
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