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  • A8326 - Anti-β-Amyloid Protein (1-40) antibody produced in rabbit

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A8326 Sigma

Anti-β-Amyloid Protein (1-40) antibody produced in rabbit

whole antiserum

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Properties

Related Categories AM-AN, Alphabetical Index, Antibodies, Antibodies for Alzheimer′s Disease, Antibodies for Neurobiology,
species reactivity   human
application(s)   dot blot: 1:6000 using β-amyloid (1-40) conjugated to KLH by dot blot immunoassay
  immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100 using human Alzheimer’s disease (AD) brain tissue
clone   polyclonal
antibody form   whole antiserum
form   liquid
contains   15 mM sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... APP(351)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic β-amyloid (1-40) conjugated to BSA.

General description

Amyloids are insoluble protein aggregates consisting of misfolded proteins and peptides. Amyloid deposition are associated with multiple neurodegenerative disorders.

The β-amyloid precursor protein (APP) is cleaved sequentially by the proteolytic enzymes β-secretase (BACE1) and γ-secretase to produce β-amyloid (Aβ) peptides with the Aβ1-42 and the Aβ1-40 forms being the most prevalent. Secreted Aβ peptides are degraded either via a re-uptake mechanism followed by endosomal degradation, or by an extracellular insulin degrading enzyme. Extracellular accumulation of Aβ leads to the formation of aggregates, fibrils and eventually amyloid deposits called neuritic plaques, which is the hallmark of Alzheimer′s disease (AD).
Rabbit Anti-β-Amyloid Protein (1-40) antibody does not stain control sections of normal brain tissues.

Weak cross-reaction is observed with β-amyloid (1-28) and β-amyloid (12-28), but no cross-reactivity is seen with calcitonin gene related peptide (CGRP)-KLH conjugate. The product may be used for the immunohistochemical detection of senile-plaques in brain sections of Alzheimer′s disease (AD) patients.

Physical form

Rabbit Anti-β-Amyloid (1-40) is supplied as a liquid containing 0.1% sodium azide as preservative.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Rabbit Anti-β-Amyloid Protein (1-40) antibody has been used in ultrasound enhanced antibody delivery systems in transgenic mice. The antibody has also been used for immunohistochemical applications.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  3
Protocols & Articles

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Antibody Explorer | Buy Primary & Secondary Antibodies

Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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A8326 Anti-β-Amyloid Protein (1-40) antibody produced in rabbit, whole antiserum

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