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  • A8344 - Anti-ARC, C-Terminal antibody produced in rabbit

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A8344 Sigma

Anti-ARC, C-Terminal antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Apoptosis Repressor with CARD

Properties

Related Categories AR-AR, Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology,
species reactivity   human
application(s)   microarray: suitable
  western blot: 1:1,000 using HeLa cell extract
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 22 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... NOL3(8996)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 191-208 of human ARC (apoptosis repressor with CARD).

General description

ARC is part of the activity regulated cytoskeleton-associated protein family. It is involved in endocytosis of AMPA receptors and formation of long-term memory. It is found expressed in the cytoplasma of neuronal dendrites.

ARC protein contains an N-terminal CARD that has homology to the CARDs present in Apaf-1 and RAIDD. It binds to and inhibits the activity of caspase 8. It also binds to caspase 9 and to Ced-3. It inhibits apoptosis induced by death receptors that require caspase 8 activation.

Rabbit Anti-ARC, C-Terminal antibody binds to amino acids 191-208 of human ARC.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Application

Rabbit Anti-ARC, C-Terminal antibody can be used for western blot (1:1,000) and microarray analyses.

Price and Availability


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