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A8398 Sigma

7-Aminodesacetoxycephalosporanic acid

Synonym: 7-ADCA




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7-Aminodesacetoxycephalosporanic acid is used in the synthesis of cephalosporins and for bioconversion studies 1.

7-Aminodesacetoxycephalosporanic acid is used in the synthesis of cephalosporins.


Bottomless glass bottle. Contents are inside inserted fused cone.

Biochem/physiol Actions

7-ADCA is produced from penicillin G made by Penicillium chrysogenum involving several polluting chemical steps followed by enzymatic deacylation using penicillin acylase 2.

Price and Availability

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Safety & Documentation

Safety Information

GHS08  GHS08
Signal word 
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
WGK Germany 


Certificate of Analysis

Certificate of Origin

Protocols & Articles

Peer-Reviewed Papers


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1. Altering the Substrate Specificity of Cephalosporin Acylase by Directed Evolution of the β-Subunit. Linda G. Otten, Charles F. Sio, et al. J. Biol. Chem. 277, 42121-42127, (2002)


2. Mutational analysis of a key residue in the substrate specificity of a cephalosporin acylase. Linda G. Otten, Charles F. Sio, et al. ChemBioChem. 6, 820-825, (2004)

Modeling of the enzymatic kinetic synthesis of cephalexin--influence of substrate concentration and temperature. Schroën CG, Nierstrasz VA, Moody HM, et al. Biotechnol. Bioeng. 73(3), 171-8, (2001)


Kinetics of enzyme acylation and deacylation in the penicillin acylase-catalyzed synthesis of beta-lactam antibiotics. Alkema WB, de Vries E, Floris R, et al. Eur. J. Biochem. 270(18), 3675-83, (2003)


Integrated reactor concepts for the enzymatic kinetic synthesis of cephalexin. Schroën CG, Nierstrasz VA, Bosma R, et al. Biotechnol. Bioeng. 80(2), 144-55, (2002)


A two-step, one-pot enzymatic synthesis of cephalexin from D-phenylglycine nitrile. Wegman MA, van Langen LM, van Rantwijk F, et al. Biotechnol. Bioeng. 79(3), 356-61, (2002)


Advantages of using non-isothermal bioreactors for the enzymatic synthesis of antibiotics: the penicillin G acylase as enzyme model. Travascio P, Zito E, De Maio A, et al. Biotechnol. Bioeng. 79(3), 334-46, (2002)


[Role of biocatalysis in the creation and improvement of production of beta-lactam antibiotics in Russia]. Nys PS and Bartoshevich IuE Antibiot. Khimioter. 39(8), 3-14, (1994)


Anaerobic stabilization and conversion of transformed intermediates of antibiotic pharmaceutical effluent in a fluidized bed reactor. Tamijevendane S, Saravanane R, Rajesh R, et al. J. Environ. Sci. Eng. 53(3), 231-6, (2011)


Effect of loading rate and HRT on the removal of cephalosporin and their intermediates during the operation of a membrane bioreactor treating pharmaceutical wastewater. Saravanane R and Sundararaman S Environ. Technol. 30(10), 1016-22, (2009)


Enzymatic preparation of cefaclor with immobilized penicillin acylase. Zhang YW and Wei DZ Prep Biochem Biotechnol. 38(2), 129-38, (2008)


[Enzymatic synthesis of cephradine]. Cui F, Shi J, and Bai X Wei Sheng Wu Xue Bao 38(4), 300-3, (1998)


[Hydrolase from Xanthomonas rubrilineans for synthesis of cefalexin]. Ivankin AN and Nekliudov AD Prikl. Biokhim. Mikrobiol. 36(3), 303-6, (2000)


Equilibrium position, kinetics, and reactor concepts for the adipyl-7-ADCA-hydrolysis process. Schroën CG, VandeWiel S, Kroon PJ, et al. Biotechnol. Bioeng. 70(6), 654-61, (2000)


Production of cephalosporin intermediates by feeding adipic acid to recombinant Penicillium chrysogenum strains expressing ring expansion activity. Crawford L, Stepan AM, McAda PC, et al. Biotechnology. (N.Y.) 13(1), 58-62, (1995)


Continuous cultivations of a Penicillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus: Kinetics of adipoyl-7-aminodeacetoxycephalosporanic acid and byproduct formations. Robin J, Bruheim P, Nielsen ML, et al. Biotechnol. Bioeng. 83(3), 353-60, (2003)


Environmentally safe production of 7-aminodeacetoxycephalosporanic acid (7-ADCA) using recombinant strains of Acremonium chrysogenum. Velasco J, Luis Adrio J, Angel Moreno M, et al. Nat. Biotechnol. 18(8), 857-61, (2000)


Continuous cultivations of a Penicillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus: Growth yields and morphological characterization. Robin J, Lettier G, McIntyre M, et al. Biotechnol. Bioeng. 83(3), 361-8, (2003)


Process design for enzymatic adipyl-7-ADCA hydrolysis. Schroën CG, Nierstrasz VA, Bosma R, et al. Biotechnol. Prog. 18(4), 745-51, (2002)


Penicillin acylase-catalyzed synthesis of beta-lactam antibiotics in highly condensed aqueous systems: beneficial impact of kinetic substrate supersaturation. Youshko MI, Moody HM, Bukhanov AL, et al. Biotechnol. Bioeng. 85(3), 323-9, (2004)


Analysis of a substrate specificity switch residue of cephalosporin acylase. Sio CF, Otten LG, Cool RH, et al. Biochem. Biophys. Res. Commun. 312(3), 755-60, (2003)


Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase. Dubus A, Lloyd MD, Lee HJ, et al. Cell. Mol. Life Sci. 58(5-6), 835-43, (2001)


Quantitative characterization of the nucleophile reactivity in penicillin acylase-catalyzed acyl transfer reactions. Youshko MI, Chilov GG, Shcherbakova TA, et al. Biochim. Biophys. Acta 1599(1-2), 134-40, (2002)


Enzymatic production of cephalexin. Maladkar NK Enzyme Microb. Technol. 16(8), 715-8, (1994)


Enzyme reaction engineering: effect of methanol on the synthesis of antibiotics catalyzed by immobilized penicillin G acylase under isothermal and non-isothermal conditions. Travascio P, Zito E, Portaccio M, et al. Biotechnol. Prog. 18(5), 975-85, (2002)


Enhanced enzymatic synthesis of a semi-synthetic cephalosprin, cefaclor, with in situ product removal. Yang L and Wei DZ Biotechnol. Lett. 25(14), 1195-8, (2003)


Enzymatic 7-ADCA: I said it couldn't be done. Demain A Biotechnology. (N.Y.) 13(1), 23-4, (1995)


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