|Related Categories||A-AM, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Biogenic Amine Transport Inhibitors,|
|color||white to off-white|
|Gene Information||human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)|
Shelf-life of the powder is at least three years.
Amitriptyline hydrochloride is a tricyclic antidepressant drug. Amitriptyline hydrochloride inhibits the norepinephrine and serotonin transporters but has a high affinity for α1-adrenergic, serotonin and muscarinic acetylcholine receptors.
Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with Kis of 100 nM and 14.7 nM, respectively; high in vitro affinity for α1-adrenoceptors, serotonin and muscarinic acetylcholine receptors.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P273-P301 + P310-P305 + P351 + P338-P501|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||Xn,N|
|Risk Statements (Europe)||22-36-50/53|
|Safety Statements (Europe)||26-60-61|
|RIDADR||UN 2811 6.1/PG 3|
Potassium channels are essential in both excitable and non-excitable cells for the control of membrane potential, regulation of cell volume, and the secretion of salt, neurotransmitters and hormones....
Keywords: Absorption, Cancer, Cell proliferation, Cell signaling, Diabetes, Diseases, Hormones, Ligands, Neurotransmitters, Phosphorylations, Sequencing
Self-association Behavior Of Amitriptyline Hydrochloride As A Function Of Temperature And Additive (inorganic Salts And Ureas) Concentration. Kabir-ud-Din, , et al. Colloids Surf., B 82, 87-94, (2011)
Micellization and clouding phenomenon of amphiphilic antidepressant drug amitriptyline hydrochloride: effect of KCl Alam, M.S., et al. Colloids Surf., B 92, 203-8, (2012)
Formulation of amphiphilic drug amitriptyline hydrochloride by polyoxyethylene sorbitan esters in aqueous electrolytic solution Kabir-ud-Din, Y. Colloids Surf., B 93, 208-14, (2012)
A Randomized Controlled Trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in the treatment of chronic tension-type facial pain. Agius AM, Jones NS, and Muscat R Rhinology 51(2), 143-53, (2013)
Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort. Kuczynski A, Crawford S, Bodell L, et al. Dev. Med. Child Neurol. 55(7), 636-41, (2013)
Effects of chronic administration of amitriptyline, gabapentin and minocycline on spinal brain-derived neurotrophic factor expression and neuropathic pain behavior in a rat chronic constriction injury model. Vanelderen P, Rouwette T, Kozicz T, et al. Reg. Anesth. Pain Med. 38(2), 124-30, (2013)
An assessment of the in vivo effects of intravenous lipid emulsion on blood drug concentration and haemodynamics following oro-gastric amitriptyline overdose. Perichon D, Turfus S, Gerostamoulos D, et al. Clin. Toxicol. (Phila.) 51(4), 208-15, (2013)
Displaced dual-mode imaging with desorption electrospray ionization for simultaneous mass spectrometry imaging in both polarities and with several scan modes. Janfelt C, Wellner N, Hansen HS, et al. J. Mass Spectrom. 48(3), 361-6, (2013)
Electromembrane surrounded solid phase microextraction: a novel approach for efficient extraction from complicated matrices. Rezazadeh M, Yamini Y, Seidi S, et al. J. Chromatogr. A 1280, 16-22, (2013)
Topical amitriptyline combined with ketamine for the treatment of erythromelalgia: a retrospective study of 36 patients at Mayo Clinic. Poterucha TJ, Weiss WT, Warndahl RA, et al. Journal. of. Drugs in. Dermatology. 12(3), 308-10, (2013)
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