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A8404 Sigma

Amitriptyline hydrochloride

≥98% (TLC), powder


Features and Benefits

Shelf-life of the powder is at least three years.


Amitriptyline hydrochloride is a tricyclic antidepressant drug. Amitriptyline hydrochloride inhibits the norepinephrine and serotonin transporters but has a high affinity for α1-adrenergic, serotonin and muscarinic acetylcholine receptors.

Biochem/physiol Actions

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with Kis of 100 nM and 14.7 nM, respectively; high in vitro affinity for α1-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Price and Availability

Suggested Laboratory Gloves

Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.

New TruPAGE™ Pre-cast Polyacrylamide Gels

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Amitriptyline hydrochloride

United States Pharmacopeia (USP) Reference Standard

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pharmaceutical secondary standard; traceable to USP, PhEur and BP

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