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A8423 Sigma

Amiodarone hydrochloride

≥98%

Synonym: (2-Butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone hydrochloride, 2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride

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Description

Packaging

1, 5, 10 g in poly bottle

Substrates

CYP2C8/9 and CYP3A family (minor pathway) inhibitor and substrate; CYP2D6, CYP3A family, CYP2D6, CYP2A6, CYP2B6 desethyl-form inhibitor

Application

Amiodarone hydrochloride is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ in Saccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. Amiodarone hydrochloride has also been used in a study to determine concentrations of thyroid disrupting substances in effluents from wastewater treatment plants.

Biochem/physiol Actions

Non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ in Saccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.1

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®,1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

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DISCOVER Bioactive Small Molecules
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
WGK Germany 
3
RTECS 
OB1361000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Discover Bioactive Small Molecules for Ion Channels Research

Ion transport across the relatively impermeable lipid bilayer of the cell membrane is accomplished via membrane proteins known as ion channels, pumps and transporters. Ion channels are gated pores an...
Keywords: Biological processes, Cell signaling, Diseases, Hormones, Ligands, Neurotransmitters

Peer-Reviewed Papers

References

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1. Global disruption of cell cycle progression and nutrient response by the antifungal agent amiodarone. Zhang, Y.Q. and Rao, R. J. Biol. Chem. 282, 37844, (2007)

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A Live Zebrafish-based Screening System For Human Nuclear Receptor Ligand And Cofactor Discovery. Tiefenbach, J., et al. PLoS ONE 5, e9797, (2010)

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Involvement of CYP3A4/5 and CYP2D6 in the metabolism of aconitine using human liver microsomes and recombinant CYP450 enzymes Tang, L., et al. Toxicol. Lett. 2022, 47-54, (2011)

Thermal behavior study and decomposition kinetics of amiodarone hydrochloride under isothermal conditions Yoshida, M.I., et al. Drug Devel. Ind. Pharm. 37, 638-47, (2011)

In vitro thyroid disrupting effects of organic extracts from WWTPs in Beijing Li, N., et al. J. Environ. Sci. (China) 23, 671-5, (2011)

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Antiarrhythmic efficacy of CPUY102122, a multiple ion channel blocker, on rabbits with ischemia/reperfusion injury. Wang M, Shan J, Yang Q, et al. Pharmacol. Rep. 66(6), 1022-30, (2014)

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Merck 14,482

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