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  • A8452 - Monoclonal Anti-α-Fetoprotein (AFP) antibody produced in mouse

A8452 Sigma

Monoclonal Anti-α-Fetoprotein (AFP) antibody produced in mouse

ascites fluid, clone C3



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Embryonic Stem Cells, Antibodies for Pluripotent Stem Cells,
species reactivity   pig, canine, human
does not react with   rat, cat, bovine, mouse
application(s)   dot blot: suitable
  immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500 using human fetal liver
  indirect ELISA: suitable
clone   C3, monoclonal
antibody form   ascites fluid
isotype   IgG2a
contains   15 mM sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... AFP(174)
biological source   mouse
conjugate   unconjugated



human α-fetoprotein

General description

α-Fetoprotein (AFP) is a one of the main glycoprotein present in the fetal liver, gastrointestinal tract, and yolk sac. AFP levels in amniotic fluid have been used as biomarkers for anencephaly and spina bifida.
Mouse Monoclonal Anti-α-Fetoprotein antibody recognizes an epitope of α-fetoprotein, present in human and several other species. Cross-reactivity has been observed with human, dog, and pig, but not with bovine, cat, rat, and mouse. The product does not cross-react with human serum albumin.

Antigen Background

AFP is a plasma protein found highly expressed in the human fetus where it functions to block the transport of estradiol across the placenta.

Physical form

The product is provided as ascites fluid with 0.1% sodium azide as a preservative.


Mouse Monoclonal Anti-α-Fetoprotein has been used for immunocytochemistry. The product can also be used for dot blot and indirect ELISA.

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Safety & Documentation

Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  3
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