|Related Categories||A-AM, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antitumor Agents,|
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Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.
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Proliferating cells require the biosynthesis of structural components for biomass production and for genomic replication. This requires a reprogramming of the metabolic pathways to ensure nutrients s...
Keywords: Aerobic, Antitumor agents, Apoptosis, Cancer, Degradations, Environmental, Gene expression, Glycolysis, Growth factors, Metabolic Pathways, Metabolism, Metabolites, Nucleotide Synthesis, PAGE, Pentose phosphate pathway, Phosphorylations
Inhibition of thymidine phosphorylase expression by using an HSP90 inhibitor potentiates the cytotoxic effect of cisplatin in non-small-cell lung cancer cells Weng, S.H., et al. Biochem. Pharmacol. 84(1), 126-36, (2012)
17-allylamino-17-demethoxygeldanamycin and ritonavir inhibit renal cancer growth by inhibiting the expression of heat shock factor-1. Sato, A., et al. Int. J. Oncol. 4191), 46-52, (2012)
In vitro and in vivo role of heat shock protein 90 in Amphotericin B resistance of Aspergillus terreus Blum, G., et al. Clin. Microbiol. Infect., doi: 10.1111/j.1469-0691.2012.03848.x., (2012)
Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone. Clarke, P.A., et al. Oncogene 19, 4125-4133, (2000)
Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts. Nimmanapalli, R., et al. Cancer Res. 61, 1799-1804, (2001)
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