17-(Allylamino)-17-demethoxygeldanamycin ≥98% (HPLC), solid

Properties

Related Categories	A-AM, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antitumor Agents, Apoptosis Inducers, Apoptosis and Cell Cycle, Benzenoids, Bioactive Small Molecules, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure Class, HSP-90 Inhibitors, Inhibits an Enzyme, Mechanism of Action More...
assay	≥98% (HPLC)
form	solid
solubility	DMSO: soluble
	methanol: soluble
shipped in	wet ice
storage temp.	−20°C

Description

Biochem/physiol Actions

Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185^erB2.

Application

17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) inhibits heat shock protein 90 (Hsp90), the expression of heat shock factor-1, and the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185^erB2. In addition to its anti-tumor effects, 17-AAG also induces apoptosis.

Price and Availability

Related Papers

Inhibition of thymidine phosphorylase expression by using an HSP90 inhibitor potentiates the cytotoxic effect of cisplatin in non-small-cell lung cancer cells Weng, S.H., et al. Biochem. Pharmacol. 84(1), 126-36, (2012)

Documents

Certificate of Analysis

Certificate of Origin

A8476 - Datasheet (52 KB)

Celltransmissions 20(2) (67 KB )

Safety Information

Personal Protective Equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany	3

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Articles

Oncogenes and Tumor Suppressors Reprogram Metabolism

Proliferating cells require the biosynthesis of structural components for biomass production and for genomic replication. This requires a reprogramming of the metabolic pathways to ensure nutrients s...
Keywords: Aerobic, Antitumor agents, Apoptosis, Cancer, Degradations, Environmental, Gene expression, Glycolysis, Growth factors, Metabolic Pathways, Metabolism, Metabolites, Nucleotide Synthesis, PAGE, Pentose phosphate pathway, Phosphorylations

Papers

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Inhibition of thymidine phosphorylase expression by using an HSP90 inhibitor potentiates the cytotoxic effect of cisplatin in non-small-cell lung cancer cells Weng, S.H., et al. Biochem. Pharmacol. 84(1), 126-36, (2012)

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17-allylamino-17-demethoxygeldanamycin and ritonavir inhibit renal cancer growth by inhibiting the expression of heat shock factor-1. Sato, A., et al. Int. J. Oncol. 4191), 46-52, (2012)

In vitro and in vivo role of heat shock protein 90 in Amphotericin B resistance of Aspergillus terreus Blum, G., et al. Clin. Microbiol. Infect., doi: 10.1111/j.1469-0691.2012.03848.x., (2012)

Impaired infectivity of ritonavir-resistant HIV is rescued by heat shock protein 90AB1. Joshi P J. Biol. Chem. 286(28), 24581-92, (2011)

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Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells. Chen G BMC Cancer 11, 170, (2011)

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Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2. Basso, A.D., et al. Oncogene 21, 1159-1166, (2002)

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Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone. Clarke, P.A., et al. Oncogene 19, 4125-4133, (2000)

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Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts. Nimmanapalli, R., et al. Cancer Res. 61, 1799-1804, (2001)

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Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives. Schnur, R.C., et al. J. Med. Chem. 38, 3806-3812, (1995)

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