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A8523 Sigma

Amoxicillin

potency: ≥900 μg per mg

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,
potency   ≥900 μg per mg
solubility   1 M NH4OH: soluble50 mg/mL
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C
solubility   Do you have solubility information on this product that you would like to share?

Description

Application

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Amoxicillin is used to study the oxygen dependent antimicrobial systems of polymorphonuclear leukocytes (PMNLs), the risk of resistance development in Helicobacter pylor, and various dosing strategies against Streptococcus pneumoniae and Pneumococcal pneumonia 1,2,3,4. It is also used to study the synthesis of bacterial cell walls at the level of peptidoglycan polymer chain cross-linking involving bacterial transpeptidase.

Biochem/physiol Actions

Amoxicillin is a broad-spectrum, β-lactam antibiotic. It inhibits the cross-linkage between linear peptidoglycan polymer chains that are the major component of both Gram-positive and Gram-negative bacteria.

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Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
Safety Statements (Europe) 
22-36/37
WGK Germany 
2
RTECS 
XH8300000

Protocols & Articles

Peer-Reviewed Papers

References

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1. An in Vitro Investigation of the Intracellular Bioactivity of Amoxicillin, Clindamycin, and Erythromycin for Staphylococcus aureus. R. Anderson, G. Joone, et. Al J. Infect. Dis. 153, 593-600, (1986)

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2. Risk of Development of In Vitro Resistance to Amoxicillin, Clarithromycin, and Metronidazole in Helicobacter pylori. Mikael Sörberg, Håkan Hanberger, et. Al Antimicrob. Agents Chemother. 42, 1222-1228, (1998)

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3. Efficacy of pulsatile amoxicillin and clarithromycin dosing alone and in combination in a murine pneumococcal pneumonia model. Heather K. Sun, Su Young Lee, et. Al J. Antimicrob. Chemother. 56, 559-565, (2005)

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4. Pulsatile delivery of amoxicillin against Streptococcus pneumoniae. Raymond Cha and Michael J. Rybak J. Antimicrob. Chemother. 54, 1067-1071, (2004)

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Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. Vincent Cattoir et al Antimicrob. Agents Chemother. 52, 3801-4, (2008)

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Emergence of metallo-?-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia. Laurent Poirel et al Antimicrob. Agents Chemother. 54, 4914-6, (2010)

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OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. Paul G Higgins et al Antimicrob. Agents Chemother. 53, 5035-8, (2009)

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The diagnosis and management of acute otitis media. Lieberthal AS, Carroll AE, Chonmaitree T, et al. Pediatrics 131(3), e964-99, (2013)

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Integron mobilization unit as a source of mobility of antibiotic resistance genes. Laurent Poirel et al Antimicrob. Agents Chemother. 53, 2492-8, (2009)

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Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. Amélie Carrër et al Antimicrob. Agents Chemother. 52, 2950-4, (2008)

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Extended-spectrum cephalosporinase in Acinetobacter baumannii. José-Manuel Rodríguez-Martínez et al Antimicrob. Agents Chemother. 54, 3484-8, (2010)

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Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. José-Manuel Rodríguez-Martínez et al Antimicrob. Agents Chemother. 53, 1766-71, (2009)

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Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. Thierry Naas et al Antimicrob. Agents Chemother. 52, 1257-63, (2008)

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Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. Delphine Girlich et al Antimicrob. Agents Chemother. 54, 328-32, (2010)

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Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. Yohei Doi et al Antimicrob. Agents Chemother. 52, 1952-6, (2008)

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Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands. Laurent Poirel et al Antimicrob. Agents Chemother. 54, 2420-4, (2010)

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Spread of OXA-48-encoding plasmid in Turkey and beyond. Amélie Carrër et al Antimicrob. Agents Chemother. 54, 1369-73, (2010)

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VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. Jose-Manuel Rodriguez-Martinez et al Antimicrob. Agents Chemother. 54, 471-6, (2010)

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The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: a systematic review. Zandbergen D, Slot DE, Cobb CM, et al. J. Periodontol. 84(3), 332-51, (2013)

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Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. Anaïs Potron et al Antimicrob. Agents Chemother. 53, 3010-6, (2009)

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Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A β-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. Stephanie Petrella et al Antimicrob. Agents Chemother. 52, 3725-36, (2008)

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bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. Björn A Espedido et al Antimicrob. Agents Chemother. 52, 2984-7, (2008)

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Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. Laurent Poirel et al Antimicrob. Agents Chemother. 53, 876-82, (2009)

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Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. Marie-Frédérique Lartigue et al Antimicrob. Agents Chemother. 51, 2855-60, (2007)

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PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. Delphine Girlich et al Antimicrob. Agents Chemother. 54, 1619-22, (2010)

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Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. Chia-Ying Liu et al Antimicrob. Agents Chemother. 52, 3161-8, (2008)

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Incidence of rash after amoxicillin treatment in children with infectious mononucleosis. Chovel-Sella A, Ben Tov A, Lahav E, et al. Pediatrics 131(5), e1424-7, (2013)

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Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. Hedi Mammeri et al Antimicrob. Agents Chemother. 53, 323-6, (2009)

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Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. Laurent Poirel et al Antimicrob. Agents Chemother. 51, 631-7, (2007)

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Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. Sohei Harada et al Antimicrob. Agents Chemother. 54, 3545-50, (2010)

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BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. Laurent Poirel et al Antimicrob. Agents Chemother. 54, 533-5, (2010)

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Microanalysis of beta-lactam antibiotics and vancomycin in plasma for pharmacokinetic studies in neonates. Maurice J Ahsman et al Antimicrob. Agents Chemother. 53, 75-80, (2009)

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Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. Véronique Dubois et al Antimicrob. Agents Chemother. 52, 3792-4, (2008)

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Multiple N-methylation by a designed approach enhances receptor selectivity. Jayanta Chatterjee et al J. Med. Chem. 50, 5878-81, (2007)

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Molecular characteristics of travel-related extended-spectrum-beta-lactamase-producing Escherichia coli isolates from the Calgary Health Region. Johann D D Pitout et al Antimicrob. Agents Chemother. 53, 2539-43, (2009)

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Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). Emilio Pérez-Trallero et al Antimicrob. Agents Chemother. 54, 2953-9, (2010)

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In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci. Wojciech Kamysz et al Antimicrob. Agents Chemother. 51, 354-8, (2007)

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Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina. Laurent Poirel et al Antimicrob. Agents Chemother. 51, 2179-84, (2007)

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Effect of structural and conformation modifications, including backbone cyclization, of hydrophilic hexapeptides on their intestinal permeability and enzymatic stability. Shmuel Hess et al J. Med. Chem. 50, 6201-11, (2007)

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Antibiotic susceptibility of Waddlia chondrophila in Acanthamoeba castellanii amoebae. Geneviève Goy et al Antimicrob. Agents Chemother. 53, 2663-6, (2009)

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Design, synthesis, and biological evaluation of 4-alkyliden-beta lactams: new products with promising antibiotic activity against resistant bacteria. Francesco Broccolo et al J. Med. Chem. 49, 2804-11, (2006)

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Effect of postoperative antibiotic administration on postoperative infection following cholecystectomy for acute calculous cholecystitis: a randomized clinical trial. Regimbeau JM, Fuks D, Pautrat K, et al. JAMA 312(2), 145-54, (2014)

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Synthesis, antifungal and antimicrobial activity of alkylphospholipids. Daniel Obando et al Bioorg. Med. Chem. 15, 5158-65, (2007)

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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. R Scott Obach et al Drug Metab. Dispos. 36, 1385-405, (2008)

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Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening. Laurence Miguet et al J. Med. Chem. 52, 5926-36, (2009)

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Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. Neil Woodford et al Antimicrob. Agents Chemother. 53, 4472-82, (2009)

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Physicochemical determinants of human renal clearance. Manthena V S Varma et al J. Med. Chem. 52, 4844-52, (2009)

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Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Manthena V S Varma et al J. Med. Chem. 53, 1098-108, (2010)

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Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks. Anouk E Muller et al Antimicrob. Agents Chemother. 51, 3720-5, (2007)

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Antibiotics for acute otitis media: yes or no. Pichichero ME JAMA 313(3), 294-5, (2015)

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In acute calculous cholecystitis, antibiotics after cholecystectomy did not reduce infection. Steinberg DI Ann. Intern. Med. 161(12), JC4, (2014)

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[Allopurinol hypersensitivity syndrome: Liver transplantation after treatment of asymptomatic hyperuricaemia]. Miederer SE and Miederer KO Dtsch. Med. Wochenschr. 139(49), 2537-40, (2014)

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Race, otitis media, and antibiotic selection. Fleming-Dutra KE, Shapiro DJ, Hicks LA, et al. Pediatrics 134(6), 1059-66, (2014)

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Amoxicillin administrations and its influence on bone repair around osseointegrated implants. Giro G, In J, Witek L, et al. J. Oral Maxillofac. Surg. 72(2), 305.e1-5, (2014)

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Expression comparison of azithromycin and clarithromycin in triple-therapy regimens for eradication of Helicobacter pylori in hemodialysis patients. Vafaeimanesh J, Jalalzadeh M, and Nazarian M Saudi J. Kidney Dis. Transpl. 25(1), 53-7, (2014)

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Treatment of fast breathing in neonates and young infants with oral amoxicillin compared with penicillin-gentamicin combination: study protocol for a randomized, open-label equivalence trial. Pediatr. Infect. Dis. J. 32 Suppl 1, S33-8, (2013)

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Simplified antibiotic regimens for the management of clinically diagnosed severe infections in newborns and young infants in first-level facilities in Karachi, Pakistan: study design for an outpatient randomized controlled equivalence trial. Zaidi AK, Tikmani SS, Sultana S, et al. Pediatr. Infect. Dis. J. 32 Suppl 1, S19-25, (2013)

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Safety and efficacy of simplified antibiotic regimens for outpatient treatment of serious infection in neonates and young infants 0-59 days of age in Bangladesh: design of a randomized controlled trial. Baqui AH, Saha SK, Ahmed AS, et al. Pediatr. Infect. Dis. J. 32 Suppl 1, S12-8, (2013)

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Nonsurgical treatment of aggressive periodontitis with photodynamic therapy or systemic antibiotics. Three-month results of a randomized, prospective, controlled clinical study. Arweiler NB, Pietruska M, Skurska A, et al. Schweiz. Monatsschr. Zahnmed. 123(6), 532-44, (2013)

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Etiology and antimicrobial susceptibility pattern of bacterial pathogens from urinary tract infection. Khatri B, Basnyat S, Karki A, et al. Nepal Med. Coll. J. 14(2), 129-32, (2012)

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Bismuth + metronidazole + tetracycline. Why risk adding bismuth? Prescrire Int. 22(137), 89-92, (2013)

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[Acute cholecystitis]. Füessl HS MMW Fortschr. Med. 155(1), 49, (2013)

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Approach to common bacterial infections: community-acquired pneumonia. Iroh Tam PY Pediatr. Clin. North Am. 60(2), 437-53, (2013)

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Dental enamel, fluorosis and amoxicillin. Ciarrocchi I, Masci C, Spadaro A, et al. Pediatr. Med. Chir. 34(3), 148-54, (2012)

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[Treatment of streptococcal tonsillitis with once-a-day amoxicillin: a meta-analysis]. Llerena Santa Cruz ED, Buñuel Álvarez JC, Porcar Farrán D, et al. An. Pediatr. (Barc.) 75(5), 298-306, (2011)

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Amoxicillin/metronidazole or scaling and root planing in the treatment of chronic periodontitis. Bono A and Brunotto M Acta Odontol. Latinoam. 23(3), 196-203, (2010)

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Formulation of controlled release gellan gum macro beads of amoxicillin. Babu RJ, Sathigari S, Kumar MT, et al. Curr. Drug Deliv. 7(1), 36-43, (2010)

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Variations in amoxicillin pharmacokinetic/pharmacodynamic parameters may explain treatment failures in acute otitis media. Pichichero ME and Reed MD Paediatr. Drugs 11(4), 243-9, (2009)

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[Cytochrome P450 2C19 genotype -based second line therapy with amoxicillin and lansoprazole after failure of initial helicobacter pylori eradication therapy]. Asano M, Taniwaki H, Tsuji D, et al. Nihon Rinsho. 63 Suppl 12, 450-3, (2005)

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Spectrophotometric determination of drugs with iodine. Karuna T, et al. J. Sci. Ind. Res. 65(10), 808, (2006)

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FDA-approved drug labeling for the study of drug-induced liver injury. Minjun Chen et al Drug Discov. Today 16, 697-703, (2011)

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

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The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis. Vincent Dubée et al Antimicrob. Agents Chemother. 55, 910-2, (2011)

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In vitro activity of OPT-80 tested against clinical isolates of toxin-producing Clostridium difficile. James A Karlowsky et al Antimicrob. Agents Chemother. 52, 4163-5, (2008)

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Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. Thierry Naas et al Antimicrob. Agents Chemother. 51, 1365-72, (2007)

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Randomised clinical trial comparing sequential and concomitant therapies for Helicobacter pylori eradication in routine clinical practice. McNicholl AG, Marin AC, Molina-Infante J, et al. Gut 63(2), 244-9, (2014)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Constitutive SoxS expression in a fluoroquinolone-resistant strain with a truncated SoxR protein and identification of a new member of the marA-soxS-rob regulon, mdtG. Anna Fàbrega et al Antimicrob. Agents Chemother. 54, 1218-25, (2010)

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Antimicrobial activity of curcumin against Helicobacter pylori isolates from India and during infections in mice. Ronita De et al Antimicrob. Agents Chemother. 53, 1592-7, (2009)

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Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. Michael R Jacobs et al Antimicrob. Agents Chemother. 54, 2716-9, (2010)

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Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2. Anne-Lise Bravetti et al Antimicrob. Agents Chemother. 53, 1667-9, (2009)

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Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. Nuno Mendonça et al Antimicrob. Agents Chemother. 51, 1946-55, (2007)

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Genipin-cross-linked fucose-chitosan/heparin nanoparticles for the eradication of Helicobacter pylori. Lin YH, Tsai SC, Lai CH, et al. Biomaterials 34(18), 4466-79, (2013)

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Effectiveness of systemic amoxicillin/metronidazole as an adjunctive therapy to full-mouth scaling and root planing in the treatment of aggressive periodontitis: a systematic review and meta-analysis. Sgolastra F, Petrucci A, Gatto R, et al. J. Periodontol. 83(6), 731-43, (2012)

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How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Alex Avdeef et al J. Med. Chem. 53, 3566-84, (2010)

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Effectiveness of systemic amoxicillin/metronidazole as adjunctive therapy to scaling and root planing in the treatment of chronic periodontitis: a systematic review and meta-analysis. Sgolastra F, Gatto R, Petrucci A, et al. J. Periodontol. 83(10), 1257-69, (2012)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors. Farhanullah et al Eur. J. Med. Chem. 44, 239-50, (2009)

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SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. C C Papagiannitsis et al Antimicrob. Agents Chemother. 51, 2185-8, (2007)

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In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. Lesley McGee et al Antimicrob. Agents Chemother. 53, 552-6, (2009)

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In vitro activity of AR-709 against Streptococcus pneumoniae. W T M Jansen et al Antimicrob. Agents Chemother. 52, 1182-3, (2008)

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blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. Elzbieta Literacka et al Antimicrob. Agents Chemother. 53, 1630-5, (2009)

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Bloodstream infections caused by extended-spectrum-beta-lactamase- producing Escherichia coli: risk factors for inadequate initial antimicrobial therapy. Mario Tumbarello et al Antimicrob. Agents Chemother. 52, 3244-52, (2008)

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Eradication of Helicobacter pylori according to 23S ribosomal RNA point mutations associated with clarithromycin resistance. Lee HJ, Kim JI, Cheung DY, et al. J. Infect. Dis. 208(7), 1123-30, (2013)

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Polyamine effects on antibiotic susceptibility in bacteria. Dong-Hyeon Kwon et al Antimicrob. Agents Chemother. 51, 2070-7, (2007)

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Antimicrobial activities of piperacillin-tazobactam against Haemophilus influenzae isolates, including beta-lactamase-negative ampicillin-resistant and beta-lactamase-positive amoxicillin-clavulanate-resistant isolates, and mutations in their quinolone resistance-determining regions. Yoichi Hirakata et al Antimicrob. Agents Chemother. 53, 4225-30, (2009)

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Detection of a new SHV-type extended-spectrum beta-lactamase, SHV-31, in a Klebsiella pneumoniae strain causing a large nosocomial outbreak in The Netherlands. A Mazzariol et al Antimicrob. Agents Chemother. 51, 1082-4, (2007)

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Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)-1,3-thiazol-2-yl]-1H-pyrazoles. Bakr F Abdel-Wahab et al Eur. J. Med. Chem. 44, 2632-5, (2009)

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Natural and synthetic 2,2-dimethylpyranocoumarins with antibacterial activity. Eleni Melliou et al J. Nat. Prod. 68, 78-82, (2005)

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Amberlite-IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: antibacterial and antifungal evaluation of the products. Abhijit Hazra et al Eur. J. Med. Chem. 46, 2132-40, (2011)

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Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs. Al-Tel, T., H.; et al. Eur. J. Med. Chem. 46, 1874, (2011)

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Influence on Mitochondria and Cytotoxicity of Different Antibiotics Administered in High Concentrations on Primary Human Osteoblasts and Cell Lines. N. Duewelhenke, O. Krut, et al. Antimicrob. Agents Chemother. 51, 54-63, (2007)

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Structure-activity relationships of phenyl-furanyl-rhodanines as inhibitors of RNA polymerase with antibacterial activity on biofilms. Philippe Villain-Guillot et al J. Med. Chem. 50, 4195-204, (2007)

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Patient and prescriber determinants for the choice between amoxicillin and broader-spectrum antibiotics: a nationwide prescription-level analysis. Blommaert A, Coenen S, Gielen B, et al. J. Antimicrob. Chemother. 68(10), 2383-92, (2013)

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Convenient synthesis and antimicrobial evaluation of some novel 2-substituted-3-methylbenzofuran derivatives. Hatem A Abdel-Aziz et al Eur. J. Med. Chem. 44, 3637-44, (2009)

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Drug-induced liver injury. Leise MD, Poterucha JJ, and Talwalkar JA Mayo Clin. Proc. 89(1), 95-106, (2014)

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Synthesis and biological evaluation of some thiazolidinone derivatives of steroid as antibacterial agents. Salman Ahmad Khan et al Eur. J. Med. Chem. 44, 2597-600, (2009)

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Anti-Helicobacter pylori compounds from Santalum album. Toshimasa Ochi et al J. Nat. Prod. 68, 819-24, (2005)

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Synthesis of uriedo and thiouriedo derivatives of peptide conjugated heterocycles - A new class of promising antimicrobials. R Suhas et al Eur. J. Med. Chem. 48, 179-91, (2012)

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Oral and parenteral therapeutic options for outpatient urinary infections caused by enterobacteriaceae producing CTX-M extended-spectrum beta-lactamases. Vidhya Prakash et al Antimicrob. Agents Chemother. 53, 1278-80, (2009)

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Capsular type and antibiotic resistance in Streptococcus agalactiae isolates from patients, ranging from newborns to the elderly, with invasive infections. Somay Yamagata Murayama et al Antimicrob. Agents Chemother. 53, 2650-3, (2009)

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Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. Te-Li Chen et al Antimicrob. Agents Chemother. 52, 2573-80, (2008)

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Otitis media. Pichichero ME Pediatr. Clin. North Am. 60(2), 391-407, (2013)

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Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates. Xiaoping Xu et al Antimicrob. Agents Chemother. 54, 1152-9, (2010)

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Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. Delphine Girlich et al Antimicrob. Agents Chemother. 51, 4009-14, (2007)

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A comparative study of sequential therapy and standard triple therapy for Helicobacter pylori infection: a randomized multicenter trial. Zhou L, Zhang J, Chen M, et al. Am. J. Gastroenterol. 109(4), 535-41, (2014)

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Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. Francis F Arhin et al Antimicrob. Agents Chemother. 53, 4762-71, (2009)

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Klebsiella pneumoniae OmpA confers resistance to antimicrobial peptides. Enrique Llobet et al Antimicrob. Agents Chemother. 53, 298-302, (2009)

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Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. Yukiko Nagano et al Antimicrob. Agents Chemother. 53, 69-74, (2009)

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Prediction of drug intestinal absorption by new linear and non-linear QSPR. Alan Talevi et al Eur. J. Med. Chem. 46, 218-28, (2011)

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Synthesis, spectral studies and in vitro antibacterial activity of steroidal thiosemicarbazone and their palladium (Pd (II)) complexes. Salman Ahmad Khan et al Eur. J. Med. Chem. 44, 2270-4, (2009)

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Synthesis, antibacterial activity, and quantitative structure-activity relationships of new (Z)-2-(nitroimidazolylmethylene)-3(2H)-benzofuranone derivatives. Narges Hadj-esfandiari et al Bioorg. Med. Chem. Lett. 17, 6354-63, (2007)

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Case report: Helicobacter suis infection in a pig veterinarian. Joosten M, Flahou B, Meyns T, et al. Helicobacter 18(5), 392-6, (2013)

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Synthesis of elastin based peptides conjugated to benzisoxazole as a new class of potent antimicrobials--A novel approach to enhance biocompatibility. R Suhas et al Eur. J. Med. Chem. 46, 704-11, (2011)

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Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. Philippe Moreillon et al Antimicrob. Agents Chemother. 51, 1661-5, (2007)

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Single-dose azithromycin versus erythromycin or amoxicillin for Chlamydia trachomatis infection during pregnancy: a meta-analysis of randomised controlled trials. Pitsouni E, Iavazzo C, Athanasiou S, et al. Int. J. Antimicrob. Agents 30(3), 213-21, (2007)

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Chemical constituents from the peels of Citrus sudachi. Hiroyuki Nakagawa et al J. Nat. Prod. 69, 1177-9, (2006)

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Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. Frédéric Robin et al Antimicrob. Agents Chemother. 54, 466-70, (2010)

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Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. Ian A Critchley et al Antimicrob. Agents Chemother. 52, 2639-43, (2008)

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Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. Mosaad S Mohamed et al Eur. J. Med. Chem. 45, 2994-3004, (2010)

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Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. Alvaro San Millan et al Antimicrob. Agents Chemother. 53, 3399-404, (2009)

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LPS-induced inflammatory response after therapy of aggressive periodontitis. Shaddox LM, Gonçalves PF, Vovk A, et al. J. Dent. Res. 92(8), 702-8, (2013)

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Synthesis and in vitro antibacterial activity of new steroidal thiosemicarbazone derivatives. Salman Ahmad Khan et al Eur. J. Med. Chem. 43, 2029-34, (2008)

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Anti-Helicobacter pylori and thrombin inhibitory components from Chinese dragon's blood, Dracaena cochinchinensis. Yingdong Zhu et al J. Nat. Prod. 70, 1570-7, (2007)

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Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. Frédéric Robin et al Antimicrob. Agents Chemother. 51, 1304-9, (2007)

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Post Groebke-Blackburn multicomponent protocol: synthesis of new polyfunctional imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrimidine derivatives as potential antimicrobial agents. Taleb H Al-Tel et al Eur. J. Med. Chem. 45, 5848-55, (2010)

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Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones. Hatem A Abdel-Aziz et al Eur. J. Med. Chem. 44, 4985-97, (2009)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. Carmen Betriu et al Antimicrob. Agents Chemother. 52, 2686-90, (2008)

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Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES ?-lactamases. Stathis D Kotsakis et al Antimicrob. Agents Chemother. 54, 4864-71, (2010)

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Contribution of a plasmid-borne blaOXA-58 gene with its hybrid promoter provided by IS1006 and an ISAba3-like element to beta-lactam resistance in acinetobacter genomic species 13TU. Te-Li Chen et al Antimicrob. Agents Chemother. 54, 3107-12, (2010)

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First occurrence of an IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19 in an isolate from France. Catherine Neuwirth et al Antimicrob. Agents Chemother. 51, 4486-8, (2007)

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Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. Alvaro San Millan et al Antimicrob. Agents Chemother. 51, 2260-4, (2007)

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Azetidinone-isothiazolidinones: stereoselective synthesis and antibacterial evaluation of new monocyclic beta-lactams. Helena Ceri? et al Bioorg. Med. Chem. 18, 3053-8, (2010)

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Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. K Mesko Meglic et al Antimicrob. Agents Chemother. 53, 287-91, (2009)

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CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. A Zioga et al Antimicrob. Agents Chemother. 53, 1256-9, (2009)

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Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter. Costas C Papagiannitsis et al Antimicrob. Agents Chemother. 53, 277-80, (2009)

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Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. Silvia García-Cobos et al Antimicrob. Agents Chemother. 52, 2407-14, (2008)

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3-(1,3,4-Thiadiazole-2-yl)quinoline derivatives: synthesis, characterization and anti-microbial activity. Abdul R Bhat et al Eur. J. Med. Chem. 46, 3158-66, (2011)

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Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety. V Tomar et al Bioorg. Med. Chem. Lett. 17, 5321-4, (2007)

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The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. Nuno Mendonça et al Antimicrob. Agents Chemother. 52, 1806-11, (2008)

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Comparison of the in vitro efficacies of moxifloxacin and amoxicillin against Listeria monocytogenes. S Grayo et al Antimicrob. Agents Chemother. 52, 1697-702, (2008)

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Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections. Julian G Hurdle et al Antimicrob. Agents Chemother. 53, 4028-31, (2009)

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Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers. David Sevillano et al Antimicrob. Agents Chemother. 53, 267-70, (2009)

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Synthesis, characterization and in vitro antibacterial activity of new steroidal 5-en-3-oxazolo and thiazoloquinoxaline. Salman A Khan et al Eur. J. Med. Chem. 43, 2040-4, (2008)

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Synthesis and in vitro anti-Helicobacter pylori activity of N-[5-(5-nitro-2-heteroaryl)-1,3,4-thiadiazol-2-yl]thiomorpholines and related compounds. Javad Mirzaei et al Eur. J. Med. Chem. 43, 1575-80, (2008)

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GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. S D Kotsakis et al Antimicrob. Agents Chemother. 54, 1331-3, (2010)

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In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. Colin S Osborne et al Antimicrob. Agents Chemother. 53, 3777-81, (2009)

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Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. Marina N Stepanova et al Antimicrob. Agents Chemother. 52, 1297-301, (2008)

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Antimicrobial susceptibilities and clinical sources of Dialister species. F Morio et al Antimicrob. Agents Chemother. 51, 4498-501, (2007)

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Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. Deborah J Griggs et al Antimicrob. Agents Chemother. 53, 3357-64, (2009)

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Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. Benoît Doublet et al Antimicrob. Agents Chemother. 53, 1944-51, (2009)

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Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155. C Hal Jones et al Antimicrob. Agents Chemother. 53, 977-86, (2009)

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Can antibiotic treatment in preweaning rats alter body composition in adulthood? Morel FB, Oosting A, Piloquet H, et al. Neonatology 103(3), 182-9, (2013)

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Characterization of CSP-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of Capnocytophaga sputigena. Hélène Guillon et al Antimicrob. Agents Chemother. 54, 2231-4, (2010)

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Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Lei Du-Cuny et al Bioorg. Med. Chem. 17, 6983-92, (2009)

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Rapid eradication of Listeria monocytogenes by moxifloxacin in a murine model of central nervous system listeriosis. Solène Grayo et al Antimicrob. Agents Chemother. 52, 3210-5, (2008)

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VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. Ines Schneider et al Antimicrob. Agents Chemother. 52, 2977-9, (2008)

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Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. Radoslaw Izdebski et al Antimicrob. Agents Chemother. 52, 1021-7, (2008)

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Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. N Pradel et al Antimicrob. Agents Chemother. 53, 242-8, (2009)

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Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives. Ajjanna M Sridhara et al Eur. J. Med. Chem. 45, 4983-9, (2010)

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New condensed pyrroles of potential biological interest syntheses and structure-activity relationship studies. Mosaad S Mohamed et al Eur. J. Med. Chem. 46, 3022-9, (2011)

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Induction of accelerated reactions to amoxicillin by T-cell effector mechanisms. Gómez E, Blanca-Lopez N, Salas M, et al. Ann. Allergy Asthma Immunol. 110(4), 267-73, (2013)

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Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. Costas C Papagiannitsis et al Antimicrob. Agents Chemother. 51, 3763-7, (2007)

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Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea. Jeong Hwan Shin et al Antimicrob. Agents Chemother. 51, 2625-7, (2007)

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Treatment of severe community-acquired pneumonia with oral amoxicillin in under-five children in developing country: a systematic review. Das RR and Singh M PLoS ONE 8(6), e66232, (2013)

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Levofloxacin/amoxicillin-based schemes vs quadruple therapy for Helicobacter pylori eradication in second-line. Di Caro S, Fini L, Daoud Y, et al. World J. Gastroenterol. 18(40), 5669-78, (2012)

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Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping. Alessandro Pedretti et al Bioorg. Med. Chem. 19, 4544-51, (2011)

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IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. Boukaré Zeba et al Antimicrob. Agents Chemother. 53, 4320-6, (2009)

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TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. Frédéric Robin et al Antimicrob. Agents Chemother. 51, 4181-3, (2007)

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Contribution of BlaA and BlaB beta-lactamases to antibiotic susceptibility of Yersinia enterocolitica biovar 1B. Zachary W Bent et al Antimicrob. Agents Chemother. 54, 4000-2, (2010)

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Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. Robert Bucki et al Antimicrob. Agents Chemother. 54, 2525-33, (2010)

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E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. Mariagrazia Perilli et al Antimicrob. Agents Chemother. 52, 915-9, (2008)

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Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. Stathis D Kotsakis et al Antimicrob. Agents Chemother. 53, 3520-3, (2009)

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Appelbaum PC.Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. Kosowska-Shick K, et al. Antimicrob. Agents Chemother. 5th ed., 53, 2176-2180, (2009)

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In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. Kristina Morgenstern et al Antimicrob. Agents Chemother. 53, 1281-4, (2009)

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Preparation, characterization and antibacterial activity of poly(epsilon-caprolactone) electrospun fibers loaded with amoxicillin for controlled release in biomedical applications. Valarezo E, Stanzione M, Tammaro L, et al. J. Nanosci. Nanotechnol. 13(3), 1717-26, (2013)

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Efficacy of the de novo-derived antimicrobial peptide WLBU2 against oral bacteria. Karen F Novak et al Antimicrob. Agents Chemother. 51, 1837-9, (2007)

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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Naomi L Kruhlak et al Toxicol. Mech. Methods 18, 217-27, (2008)

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Comparison of the efficacies of oral beta-lactams in selection of Haemophilus influenzae transformants with mutated ftsI genes. Sho Takahata et al Antimicrob. Agents Chemother. 52, 1880-3, (2008)

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QSAR-based solubility model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 18, 7078-84, (2010)

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influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhibiting an N526K mutation in the ftsI gene. M Torrico et al Antimicrob. Agents Chemother. 51, 3699-706, (2007)

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Neural computational prediction of oral drug absorption based on CODES 2D descriptors. A Guerra et al Eur. J. Med. Chem. 45, 930-40, (2010)

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Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. Djalal Meziane-Cherif et al Antimicrob. Agents Chemother. 52, 1264-8, (2008)

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Antimicrobial susceptibilities of Peptostreptococcus anaerobius and the newly described Peptostreptococcus stomatis isolated from various human sources. Eija Könönen et al Antimicrob. Agents Chemother. 51, 2205-7, (2007)

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QSAR-based permeability model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 19, 2615-24, (2011)

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New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. Ines Schneider et al Antimicrob. Agents Chemother. 53, 4518-21, (2009)

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Comparative antipneumococcal activities of sulopenem and other drugs. Klaudia Kosowska-Shick et al Antimicrob. Agents Chemother. 53, 2239-47, (2009)

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Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. Benoît Doublet et al Antimicrob. Agents Chemother. 54, 45-51, (2010)

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Once or twice daily versus three times daily amoxicillin with or without clavulanate for the treatment of acute otitis media. Thanaviratananich S, Laopaiboon M, and Vatanasapt P Cochrane Database Syst. Rev. (4), CD004975, (2008)

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Antistreptococcal activity of AR-709 compared to that of other agents. Kathy Smith et al Antimicrob. Agents Chemother. 52, 2279-82, (2008)

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Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of cefditoren-pivoxil. David Sevillano et al Antimicrob. Agents Chemother. 52, 1184-6, (2008)

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Synthesis and in vitro antimicrobial activity of new 2-[p-substituted-benzyl]-5-[substituted-carbonylamino]benzoxazoles. Betul Tekiner-Gulbas et al Eur. J. Med. Chem. 42, 1293-9, (2007)

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Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4-thiadiazoles with certain sulfur containing alkyl side chain. Alireza Foroumadi et al Bioorg. Med. Chem. Lett. 18, 3315-20, (2008)

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Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. Mariagrazia Perilli et al Antimicrob. Agents Chemother. 51, 2988-90, (2007)

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Photodegradation of amoxicillin in aqueous solution under simulated irradiation: influencing factors and mechanisms. Zhao Q, Feng L, Cheng X, et al. Water Sci. Technol. 67(7), 1605-11, (2013)

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Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)

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The NOTA Study (Non Operative Treatment for Acute Appendicitis): prospective study on the efficacy and safety of antibiotics (amoxicillin and clavulanic acid) for treating patients with right lower quadrant abdominal pain and long-term follow-up of conservatively treated suspected appendicitis. Di Saverio S, Sibilio A, Giorgini E, et al. Ann. Surg. 260(1), 109-17, (2014)

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Antianaerobic activity of sulopenem compared to six other agents. Lois M Ednie et al Antimicrob. Agents Chemother. 53, 2163-70, (2009)

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In vitro inhibitory activity of boropinic acid against Helicobacter pylori. Francesco Epifano et al Bioorg. Med. Chem. Lett. 16, 5523-5, (2006)

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Dexamethasone as adjuvant therapy to moxifloxacin attenuates valve destruction in experimental aortic valve endocarditis due to Staphylococcus aureus. Ioannis Skiadas et al Antimicrob. Agents Chemother. 51, 2848-54, (2007)

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Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. Pierre Abgueguen et al Antimicrob. Agents Chemother. 51, 208-14, (2007)

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Anti-Helicobacter pylori and urease inhibition activities of some traditional medicinal plants. Amin M, Anwar F, Naz F, et al. Molecules 18(2), 2135-49, (2013)

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Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. Filomena De Luca et al Antimicrob. Agents Chemother. 54, 1547-54, (2010)

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Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. Wei Shi et al Bioorg. Med. Chem. Lett. 21, 1060-3, (2011)

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In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. Gregory G Stone et al Antimicrob. Agents Chemother. 52, 2663-6, (2008)

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Effects of Helicobacter pylori treatment on gastric cancer incidence and mortality in subgroups. Li WQ, Ma JL, Zhang L, et al. J. Natl. Cancer Inst. 106(7), doi:10.1093/jnci/dju116, (2014)

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Antibiotics for mastitis in breastfeeding women. Jahanfar S, Ng CJ, and Teng CL Cochrane Database Syst. Rev. 2, CD005458, (2013)

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In vitro activity of tebipenem, a new oral carbapenem antibiotic, against beta-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae. Kozue Kishii et al Antimicrob. Agents Chemother. 54, 3970-3, (2010)

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The role of phenoxymethylpenicillin, amoxicillin, metronidazole and clindamycin in the management of acute dentoalveolar abscesses--a review. Ellison SJ Br. Dent. J. 206(7), 357-62, (2009)

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Activity of the Diaminopyrimidine AR-709 against recently collected multidrug-resistant isolates of invasive Streptococcus pneumoniae from North America. Roseanne A Ressner et al Antimicrob. Agents Chemother. 52, 1147-9, (2008)

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Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. Djalal Meziane-Cherif et al Antimicrob. Agents Chemother. 52, 551-6, (2008)

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Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. Yue Huang et al Antimicrob. Agents Chemother. 51, 4336-41, (2007)

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Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination. Alvaro San Millan et al Antimicrob. Agents Chemother. 54, 1506-11, (2010)

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Oral administration of drugs with hypersensitivity potential induces germinal center hyperplasia in secondary lymphoid organ/tissue in Brown Norway rats, and this histological lesion is a promising candidate as a predictive biomarker for drug hypersensitivity occurrence in humans. Tamura A, Miyawaki I, Yamada T, et al. Toxicol. Appl. Pharmacol. 271(1), 30-40, (2013)

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Amoxicillin and amoxicillin plus clavulanate: a safety review. Salvo F, De Sarro A, Caputi AP, et al. Expert Opin. Drug Saf. 8(1), 111-8, (2009)

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Antibiotic resistance of Helicobacter pylori in Mashhad, Iran. Zendedel A, Moradimoghadam F, Almasi V, et al. J. Pak. Med. Assoc. 63(3), 336-9, (2013)

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Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells. Chih-Ho Lai et al Bioorg. Med. Chem. Lett. 20, 5462-5, (2010)

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Prevalence and correlates of treatment failure among Kenyan children hospitalised with severe community-acquired pneumonia: a prospective study of the clinical effectiveness of WHO pneumonia case management guidelines. Agweyu A, Kibore M, Digolo L, et al. Trop. Med. Int. Health 19(11), 1310-20, (2014)

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Amoxicillin-associated interference in an HPLC-EC assay for urinary fractionated metanephrines: potential pitfall in pheochromocytoma biochemical diagnosis. Barco S, Alpigiani MG, Ghiggeri GM, et al. Clin. Biochem. 47(15), 119-21, (2014)

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A randomized trial of standard-dose versus half-dose rabeprazole, clarithromycin, and amoxicillin in the treatment of Helicobacter pylori infection. Mansour NM, Hashash JG, El-Halabi M, et al. Eur. J. Gastroenterol. Hepatol. 23(10), 865-70, (2011)

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Propenylamide and propenylsulfonamide cephalosporins as a novel class of anti-MRSA beta-lactams. Jens Pohlmann et al Bioorg. Med. Chem. Lett. 20, 4635-8, (2010)

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In vitro effect of amoxicillin and clarithromycin on the 3' region of cagA gene in Helicobacter pylori isolates. Bustamante-Rengifo JA, Matta AJ, Pazos A, et al. World J. Gastroenterol. 19(36), 6044-54, (2013)

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Effect of antimicrobial treatment of acute otitis media on the daily disappearance of middle ear effusion: a placebo-controlled trial. Tapiainen T, Kujala T, Renko M, et al. JAMA Pediatr. 168(7), 635-41, (2014)

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Review of pharmacokinetic, pharmacodynamic and clinical studies with a modern combination of amoxicillin/sulbactam. Soutric J, Bantar C, Caruso N, et al. Chemotherapy 52(4), 200-4, (2006)

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Bioluminescent imaging of pneumococcal otitis media in chinchillas. Johnson AW, Sidman JD, and Lin J Ann. Otol. Rhinol. Laryngol. 122(5), 344-52, (2013)

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Granulomatous gastritis and Helicobacter pylori infection. Delgado JS, Landa E, and Ben-Dor D Isr. Med. Assoc. J. 15(6), 317-8, (2013)

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Bioequivalence study of two commercial amoxicillin suspension formulations in healthy human volunteers. Franco GC, Baglie S, Ruenis AP, et al. Int. J. Clin. Pharmacol. Ther. 52(5), 425-30, (2014)

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[Betalactam antibiotics combined with bectalactamases inhibitors. Amoxicillin-sulbactam]. Barcelona L, Marín M, and Stamboulian D Medicina (B. Aires.) 68(1), 65-74, (2008)

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Inhibitory and bactericidal activity of selected South African honeys and their solvent extracts against clinical isolates of Helicobacter pylori. Manyi-Loh CE, Clarke AM, Green E, et al. Pak. J. Pharm. Sci. 26(5), 897-906, (2013)

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[Helicobacter pylori eradication: current status]. Tsukanov VV, Amel'chugova OS, Butorin NN, et al. Ter. Arkh. 85(2), 73-5, (2013)

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Clinical trial evidence to advance the science of cholecystectomy. Solomkin JS JAMA 312(2), 135-6, (2014)

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Once or twice daily versus three times daily amoxicillin with or without clavulanate for the treatment of acute otitis media. Thanaviratananich S, Laopaiboon M, and Vatanasapt P Cochrane Database Syst. Rev. 12, CD004975, (2013)

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Antibiotics in acute non-pneumonic lower-respiratory tract infection--authors' reply. Little P, Stuart B, and Mullee M Lancet Infect. Dis. 13(10), 833-4, (2013)

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Fixed drug eruption: a selective reaction to amoxicillin. Chaabane A, Fredj NB, Chadly Z, et al. Therapie. 68(3), 183-5, (2013)

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[Mechanism of amoxicillin induced peripheral thrombocytopenia: about one case]. Ksouda K, Affes H, Lahieni D, et al. Therapie. 68(3), 171-2, (2013)

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It sounds like a relapsing polychondritis. Belot A, Collardeau-Frachon S, Bellil D, et al. Lancet Infect. Dis. 13(7), 638, (2013)

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Clinical practice guideline for the diagnosis and management of acute bacterial sinusitis in children aged 1 to 18 years. Wald ER, Applegate KE, Bordley C, et al. Pediatrics 132(1), e262-80, (2013)

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Antibiotics for uncomplicated severe malnutrition. Koumans EH, Routh JA, and Davis MK N. Engl. J. Med. 368(25), 2435, (2013)

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Antibiotics for uncomplicated severe malnutrition. Trehan I, Maleta KM, and Manary MJ N. Engl. J. Med. 368(25), 2436-7, (2013)

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In vitro production of Ag-specific IFN-gamma in patients with delayed hypersensitivity to amoxicillin. Martínez-Aranguren R, Gamboa PM, García-Lirio E, et al. J. Investig. Allergol. Clin. Immunol. 23(2), 125-6, (2013)

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[Is sequential eradication of Helicobacter pylori effective? Sequential treatment more effective than triple therapy in patients with clarithromycin resistance]. Malfertheiner P Dtsch. Med. Wochenschr. 138(13), 628, (2013)

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Erysipelas and acute myocarditis: an unusual combination. Domínguez F, Cobo-Marcos M, Guzzo G, et al. Can. J. Cardiol. 29(9), 1138.e3-5, (2013)

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Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. Vera Manageiro et al Antimicrob. Agents Chemother. 54, 2271-2, (2010)

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First isolation of the blaOXA-23 carbapenemase gene from an environmental Acinetobacter baumannii isolate. Delphine Girlich et al Antimicrob. Agents Chemother. 54, 578-9, (2010)

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TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. Michael R Mulvey et al Antimicrob. Agents Chemother. 53, 4955-6, (2009)

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Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland. Anna Baraniak et al Antimicrob. Agents Chemother. 53, 4565-7, (2009)

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Sitafloxacin and garenoxacin may overcome the antibiotic resistance of Helicobacter pylori with gyrA mutation. Hidekazu Suzuki et al Antimicrob. Agents Chemother. 53, 1720-1, (2009)

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IncA/C plasmid-mediated florfenicol resistance in the catfish pathogen Edwardsiella ictaluri. Timothy J Welch et al Antimicrob. Agents Chemother. 53, 845-6, (2009)

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Codetection of blaOXA-23-like gene (blaOXA-133) and blaOXA-58 in Acinetobacter radioresistens: report from the SENTRY antimicrobial surveillance program. Rodrigo E Mendes et al Antimicrob. Agents Chemother. 53, 843-4, (2009)

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Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog. Constança Pomba et al Antimicrob. Agents Chemother. 53, 327-8, (2009)

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In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. Asunción Fenoll et al Antimicrob. Agents Chemother. 52, 4209-10, (2008)

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Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. Gaelle Cuzon et al Antimicrob. Agents Chemother. 52, 3463-4, (2008)

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Expanded-spectrum beta-lactamase PER-1 in an environmental Aeromonas media isolate from Switzerland. Renata Cristina Picão et al Antimicrob. Agents Chemother. 52, 3461-2, (2008)

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Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae. Nuno Mendonça et al Antimicrob. Agents Chemother. 52, 1897-8, (2008)

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Plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in Klebsiella pneumoniae isolate from Greece. Gaelle Cuzon et al Antimicrob. Agents Chemother. 52, 796-7, (2008)

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Molecular epidemiology of imipenem-resistant Acinetobacter haemolyticus and Acinetobacter baumannii isolates carrying plasmid-mediated OXA-40 from a Portuguese hospital. Sandra Quinteira et al Antimicrob. Agents Chemother. 51, 3465-6, (2007)

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First occurrence of an Escherichia coli clinical isolate producing the VIM-1/VIM-2 hybrid metallo-beta-lactamase VIM-12. Alexandros Ikonomidis et al Antimicrob. Agents Chemother. 51, 3038-9, (2007)

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Ampicillin and amoxicillin. Malik ZA and Litman N Pediatr. Rev. 27(11), 434-6, (2006)

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