|Related Categories||Glycan Component Classes, Glycobiology, Molecular Biology, O-Glycans, O-Linked Sialylated Glycans,|
|biological source||from bovine milk or colostrum|
3′-Sialyllactose is a compound where in the acetylneuraminyl (NANA) unit is connected to the galactosyl unit of lactose at the 3 position. In 6’-sialylactose, this connection is at the 6 position. 3′-Sialyllactose and 6′-Sialyllactose are used to differentiate and characterize binding domains of viruses, such as influenza and rhinitis viruses, that recognize NANA capped cell surface receptors. 3′-Sialyllactose and 6’-sialylactose are used as reference compounds in analytical methods developed to measure their presence in materials such as milk and colostrums.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. A8681.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
The analysis of the glycan portion of glycoproteins is necessary for monitoring changes in post-translational modification that occur in disease states, as well as evaluating the consistency of glyco...
BioFiles 2007, 2.1, 18.
Keywords: Chromatography, Digestions, Electrophoresis, Gel electrophoresis, Gene expression, Glycosylations, High performance liquid chromatography, Mass spectrometry, N-linked glycosylation, Phase transitions, Post translational modifications, Purification, Separation, Sequencing
O-Linked Neutral Glycans O-Linked Sialylated Glycans Blood Group Antigens Lewis and Cell Adhesion Glycans α-Gal-(1→3)-Gal Antigens
Glycobiology Analysis Manual, 2nd Edition
Keywords: Adhesion, Catalysis, Coagulation, Degradations, Environmental, Gene expression, Glycosylations, Inflammation, Ligands, O-linked glycosylation, Phosphorylations, Transcription
Sialyllactose in viral membrane gangliosides is a novel molecular recognition pattern for mature dendritic cell capture of HIV-1. Izquierdo-Useros N, Lorizate M, Contreras FX, et al. PLoS Biol. 10(4), e1001315, (2012)
X-ray structures of human galectin-9 C-terminal domain in complexes with a biantennary oligosaccharide and sialyllactose. Yoshida H, Teraoka M, Nishi N, et al. J. Biol. Chem. 285(47), 36969-76, (2010)
Ferrocenes with two carbohydrate appendages at the upper and lower rings are useful for investigating carbohydrate-carbohydrate interactions. Otsuka A, Sakurai K, and Hasegawa T Chem. Commun. (36), 5442-4, (2009)
Chemical characterization of the oligosaccharides in Bryde's whale (Balaenoptera edeni) and Sei whale (Balaenoptera borealis lesson) milk. Urashima T, Kobayashi M, Asakuma S, et al. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 146(2), 153-9, (2007)
A new technique distinguishing alpha2-3 sialyl linkage from alpha2-6 linkage in sialyllactoses and sialyl-N-acetyllactosamines by post-source decay fragmentation method of MALDI-TOF mass spectrometry. Yamagaki T and Nakanishi H Glycoconj. J. 16(8), 385-9, (1999)
Genetic analysis reveals that both haemagglutinin and neuraminidase determine the sensitivity of naturally occurring avian influenza viruses to zanamivir in vitro. Baigent SJ, Bethell RC, and McCauley JW Virology 263(2), 323-38, (1999)
[Animal model of distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy and preclinical trial with sugar compounds]. Noguchi S, Malicdan MC, and Nishino I Brain Nerve 62(6), 601-7, (2010)
Reference values of serum total sialic acid for healthy adult subjects and comparison of two different calibrators for quantitation of total sialic acid in high performance anion-exchange chromatography with pulsed amperometric detection. Romppanen J, Romppanen EL, Halonen T, et al. Clin. Chem. Lab Med. 41(8), 1095-6, (2003)
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